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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. CDN Services

We are analyzing https://link.springer.com/article/10.1208/s12248-010-9210-4.

Title:
Delivery of siRNA Therapeutics: Barriers and Carriers | The AAPS Journal
Description:
RNA interference is a naturally occurring endogenous regulatory process where short double-stranded RNA causes sequence-specific posttranscriptional gene silencing. Small interference RNA (siRNA) represents a promising therapeutic strategy. Clinical evaluations of siRNA therapeutics in locoregional treatment settings began in 2004. Systemic siRNA therapy is hampered by the barriers for siRNA to reach their intended targets in the cytoplasm and to exert their gene silencing activity. The three goals of this review were to provide an overview of (a) the barriers to siRNA delivery, from the perspectives of physicochemical properties of siRNA, pharmacokinetics and biodistribution, and intracellular trafficking; (b) the non-viral siRNA carriers including cell-penetrating peptides, polymers, dendrimers, siRNA bioconjugates, and lipid-based siRNA carriers; and (c) the current status of the clinical trials of siRNA therapeutics.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {๐Ÿ“š}

  • Education
  • Transportation
  • Science

Content Management System {๐Ÿ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {๐Ÿ“ˆ}

What is the average monthly size of link.springer.com audience?

๐ŸŒ  Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {๐Ÿ’ธ}

We see no obvious way the site makes money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {๐Ÿ”}

article, google, scholar, pubmed, cas, sirna, delivery, gene, drug, rna, rev, silencing, deliv, adv, vivo, therapeutics, pharm, therapy, small, nature, interfering, nanoparticles, cancer, systemic, nonviral, sci, cells, nat, dendrimers, chem, davis, ther, res, control, release, interference, short, sirnas, bioconjug, biotechnol, usa, polyamidoamine, targeting, targeted, privacy, cookies, content, journal, barriers, carriers,

Topics {โœ’๏ธ}

month download article/chapter cell-penetrating peptides modified rna-interference-based therapeutics short double-stranded rna cyclodextrin polymer-based nanoparticle rnai-mediated gene-targeting cyclodextrin-based supramolecular architectures cell type-specific delivery rnai-mediated gene silencing lipid-based systemic delivery post-transcriptional gene silencing cationic oligopeptide-mediated delivery target-independent angiogenesis suppression lipid-based sirna carriers induce sequence-specific silencing short interfering rna anti-vegf sirna encapsulated small interference rna small interfering rna small-interfering rna liposome-entrapped proteins injected optimized alpha-cyclodextrin conjugate chitosan-coated plga nanoparticles vivo anti-hbv activity full article pdf small interfering rnas double-stranded rna pulmonary gene therapy short hairpin rnas aptamerโ€“sirna chimeras specific genetic interference systemic sirna therapy tumor cells induced privacy choices/manage cookies sequence-specific knockdown ovarian carcinoma therapy related subjects tumor-specific targeting dna/rna delivery small silencing rnas cell-surface receptors research grant r43ca134047 bartlett dw gene silencing activity gene silencing characteristics intravaginal gene silencing cancer sirna therapy rna interference gene transfer efficiency viral sirna delivery

Schema {๐Ÿ—บ๏ธ}

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         headline:Delivery of siRNA Therapeutics: Barriers and Carriers
         description:RNA interference is a naturally occurring endogenous regulatory process where short double-stranded RNA causes sequence-specific posttranscriptional gene silencing. Small interference RNA (siRNA) represents a promising therapeutic strategy. Clinical evaluations of siRNA therapeutics in locoregional treatment settings began in 2004. Systemic siRNA therapy is hampered by the barriers for siRNA to reach their intended targets in the cytoplasm and to exert their gene silencing activity. The three goals of this review were to provide an overview of (a) the barriers to siRNA delivery, from the perspectives of physicochemical properties of siRNA, pharmacokinetics and biodistribution, and intracellular trafficking; (b) the non-viral siRNA carriers including cell-penetrating peptides, polymers, dendrimers, siRNA bioconjugates, and lipid-based siRNA carriers; and (c) the current status of the clinical trials of siRNA therapeutics.
         datePublished:2010-06-11T00:00:00Z
         dateModified:2010-06-11T00:00:00Z
         pageStart:492
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      headline:Delivery of siRNA Therapeutics: Barriers and Carriers
      description:RNA interference is a naturally occurring endogenous regulatory process where short double-stranded RNA causes sequence-specific posttranscriptional gene silencing. Small interference RNA (siRNA) represents a promising therapeutic strategy. Clinical evaluations of siRNA therapeutics in locoregional treatment settings began in 2004. Systemic siRNA therapy is hampered by the barriers for siRNA to reach their intended targets in the cytoplasm and to exert their gene silencing activity. The three goals of this review were to provide an overview of (a) the barriers to siRNA delivery, from the perspectives of physicochemical properties of siRNA, pharmacokinetics and biodistribution, and intracellular trafficking; (b) the non-viral siRNA carriers including cell-penetrating peptides, polymers, dendrimers, siRNA bioconjugates, and lipid-based siRNA carriers; and (c) the current status of the clinical trials of siRNA therapeutics.
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      dateModified:2010-06-11T00:00:00Z
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         Pharmacy
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External Links {๐Ÿ”—}(318)

Analytics and Tracking {๐Ÿ“Š}

  • Google Tag Manager

Libraries {๐Ÿ“š}

  • Clipboard.js
  • Particles.js
  • Prism.js

CDN Services {๐Ÿ“ฆ}

  • Crossref

4.69s.