We are analyzing https://link.springer.com/article/10.1186/s40880-015-0001-2.

Title:
Association of the Asp312Asn and Lys751Gln polymorphisms in the XPD gene with the risk of non-Hodgkin’s lymphoma: evidence from a meta-analysis | Cancer Communications
Description:
Polymorphisms in DNA repair genes may alter DNA repair capacity and, consequently, lead to genetic instability and carcinogenesis. Several studies have investigated the association of the Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementation group D (XPD) gene with the risk of non-Hodgkin’s lymphoma (NHL), but the conclusions have been inconsistent. Therefore, we performed this meta-analysis to more precisely estimate these relationships. A systematic literature search was performed using the PubMed, Embase, and Chinese Biomedical (CBM) databases. Ultimately, 6 studies of Asp312Asn, comprising 3,095 cases and 3,306 controls, and 7 studies of Lys751Gln, consisting of 3,249 cases and 3,676 controls, were included. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of each association. Overall, no association was observed between the Asp312Asn polymorphism and NHL risk (homozygous: OR = 1.11, 95% CI = 0.94-1.32; heterozygous: OR = 1.00, 95% CI = 0.89-1.11; recessive: OR = 1.12, 95% CI = 0.95-1.31; dominant: OR = 1.02, 95% CI = 0.92-1.13; and allele comparison: OR = 1.04, 95% CI = 0.96-1.12) or between the Lys751Gln polymorphism and NHL risk (homozygous: OR = 0.97, 95% CI = 0.83-1.15; heterozygous: OR = 0.96, 95% CI = 0.86-1.06; recessive: OR = 1.00, 95% CI = 0.86-1.16; dominant: OR = 0.96, 95% CI = 0.87-1.06; and allele comparison: OR = 0.98, 95% CI = 0.91-1.05). Furthermore, subgroup analyses did not reveal any association between these polymorphisms and ethnicity, the source of the controls, or the NHL subtype. These results indicated that neither the Asp312Asn nor Lys751Gln XPD polymorphism was related to NHL risk. Large and well-designed prospective studies are required to confirm this finding.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Insurance
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

nhl, risk, pubmed, dna, lysgln, xpd, article, aspasn, polymorphisms, repair, polymorphism, cancer, google, scholar, association, metaanalysis, gene, lymphoma, studies, cas, controls, study, data, genes, dominant, nonhodgkin, nonhodgkins, wang, homozygous, heterozygous, recessive, allele, comparison, zhu, genetic, group, cases, source, results, damage, publications, central, analysis, search, chinese, chen, performed, ors, ethnicity, susceptibility,

Topics {✒️}

chi square-based q-test article download pdf t-cell lymphomas characterized wide-ranging cellular response wei-hua jia eligible case-control studies genetics models open access license dna repair pathways google scholar xeroderma pigmentosum group central region population complex multi-step process nested case-control case-control design case-control study including bulky adducts nucleotide excision repair jin-hong zhu privacy choices/manage cookies dna damage induced dna repair capacity wen-qiong xue excision repair genes damaged dna incision damaged dna fragment dna repair genes b-cell lymphoma risk gapped dna repair genetic complementation groups b-cell lymphomas comprehensive literature search full size image reducing dna repair mtr dna repair systematic literature search transcription-coupled repair [31] full size table collaborative innovation center large heterogeneous group maintain genomic stability national science fund largest sample size linear regression test original genotyping data single nucleotide polymorphism excessive cell death oxidative dna damage cancer shen chen identify publications reporting

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Association of the Asp312Asn and Lys751Gln polymorphisms in the XPD gene with the risk of non-Hodgkin’s lymphoma: evidence from a meta-analysis
         description:Polymorphisms in DNA repair genes may alter DNA repair capacity and, consequently, lead to genetic instability and carcinogenesis. Several studies have investigated the association of the Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementation group D (XPD) gene with the risk of non-Hodgkin’s lymphoma (NHL), but the conclusions have been inconsistent. Therefore, we performed this meta-analysis to more precisely estimate these relationships. A systematic literature search was performed using the PubMed, Embase, and Chinese Biomedical (CBM) databases. Ultimately, 6 studies of Asp312Asn, comprising 3,095 cases and 3,306 controls, and 7 studies of Lys751Gln, consisting of 3,249 cases and 3,676 controls, were included. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of each association. Overall, no association was observed between the Asp312Asn polymorphism and NHL risk (homozygous: OR = 1.11, 95% CI = 0.94-1.32; heterozygous: OR = 1.00, 95% CI = 0.89-1.11; recessive: OR = 1.12, 95% CI = 0.95-1.31; dominant: OR = 1.02, 95% CI = 0.92-1.13; and allele comparison: OR = 1.04, 95% CI = 0.96-1.12) or between the Lys751Gln polymorphism and NHL risk (homozygous: OR = 0.97, 95% CI = 0.83-1.15; heterozygous: OR = 0.96, 95% CI = 0.86-1.06; recessive: OR = 1.00, 95% CI = 0.86-1.16; dominant: OR = 0.96, 95% CI = 0.87-1.06; and allele comparison: OR = 0.98, 95% CI = 0.91-1.05). Furthermore, subgroup analyses did not reveal any association between these polymorphisms and ethnicity, the source of the controls, or the NHL subtype. These results indicated that neither the Asp312Asn nor Lys751Gln XPD polymorphism was related to NHL risk. Large and well-designed prospective studies are required to confirm this finding.
         datePublished:2015-03-05T00:00:00Z
         dateModified:2015-03-05T00:00:00Z
         pageStart:1
         pageEnd:7
         license:https://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s40880-015-0001-2
         keywords:
             XPD gene
            DNA repair
            Polymorphism
            Non-Hodgkin’s lymphoma
            Meta-analysis
            Cancer Research
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs40880-015-0001-2/MediaObjects/40880_2015_1_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs40880-015-0001-2/MediaObjects/40880_2015_1_Fig2_HTML.gif
         isPartOf:
            name:Chinese Journal of Cancer
            issn:
               1944-446X
            volumeNumber:34
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Shen Chen
               affiliation:
                     name:Sun Yat-sen University Cancer Center
                     address:
                        name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jin-Hong Zhu
               affiliation:
                     name:Harbin Medical University Cancer Hospital
                     address:
                        name:Molecular Epidemiology Lab and Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin, P. R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Fang Wang
               affiliation:
                     name:Sun Yat-sen University Cancer Center
                     address:
                        name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shao-Yi Huang
               affiliation:
                     name:Sun Yat-sen University Cancer Center
                     address:
                        name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wen-Qiong Xue
               affiliation:
                     name:Sun Yat-sen University Cancer Center
                     address:
                        name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhuo Cui
               affiliation:
                     name:University of California
                     address:
                        name:Department of Statistics, University of California, Berkeley, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jing He
               affiliation:
                     name:Sun Yat-sen University Cancer Center
                     address:
                        name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Wei-Hua Jia
               affiliation:
                     name:Sun Yat-sen University Cancer Center
                     address:
                        name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Association of the Asp312Asn and Lys751Gln polymorphisms in the XPD gene with the risk of non-Hodgkin’s lymphoma: evidence from a meta-analysis
      description:Polymorphisms in DNA repair genes may alter DNA repair capacity and, consequently, lead to genetic instability and carcinogenesis. Several studies have investigated the association of the Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementation group D (XPD) gene with the risk of non-Hodgkin’s lymphoma (NHL), but the conclusions have been inconsistent. Therefore, we performed this meta-analysis to more precisely estimate these relationships. A systematic literature search was performed using the PubMed, Embase, and Chinese Biomedical (CBM) databases. Ultimately, 6 studies of Asp312Asn, comprising 3,095 cases and 3,306 controls, and 7 studies of Lys751Gln, consisting of 3,249 cases and 3,676 controls, were included. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of each association. Overall, no association was observed between the Asp312Asn polymorphism and NHL risk (homozygous: OR = 1.11, 95% CI = 0.94-1.32; heterozygous: OR = 1.00, 95% CI = 0.89-1.11; recessive: OR = 1.12, 95% CI = 0.95-1.31; dominant: OR = 1.02, 95% CI = 0.92-1.13; and allele comparison: OR = 1.04, 95% CI = 0.96-1.12) or between the Lys751Gln polymorphism and NHL risk (homozygous: OR = 0.97, 95% CI = 0.83-1.15; heterozygous: OR = 0.96, 95% CI = 0.86-1.06; recessive: OR = 1.00, 95% CI = 0.86-1.16; dominant: OR = 0.96, 95% CI = 0.87-1.06; and allele comparison: OR = 0.98, 95% CI = 0.91-1.05). Furthermore, subgroup analyses did not reveal any association between these polymorphisms and ethnicity, the source of the controls, or the NHL subtype. These results indicated that neither the Asp312Asn nor Lys751Gln XPD polymorphism was related to NHL risk. Large and well-designed prospective studies are required to confirm this finding.
      datePublished:2015-03-05T00:00:00Z
      dateModified:2015-03-05T00:00:00Z
      pageStart:1
      pageEnd:7
      license:https://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s40880-015-0001-2
      keywords:
          XPD gene
         DNA repair
         Polymorphism
         Non-Hodgkin’s lymphoma
         Meta-analysis
         Cancer Research
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs40880-015-0001-2/MediaObjects/40880_2015_1_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs40880-015-0001-2/MediaObjects/40880_2015_1_Fig2_HTML.gif
      isPartOf:
         name:Chinese Journal of Cancer
         issn:
            1944-446X
         volumeNumber:34
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Shen Chen
            affiliation:
                  name:Sun Yat-sen University Cancer Center
                  address:
                     name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jin-Hong Zhu
            affiliation:
                  name:Harbin Medical University Cancer Hospital
                  address:
                     name:Molecular Epidemiology Lab and Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin, P. R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fang Wang
            affiliation:
                  name:Sun Yat-sen University Cancer Center
                  address:
                     name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shao-Yi Huang
            affiliation:
                  name:Sun Yat-sen University Cancer Center
                  address:
                     name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wen-Qiong Xue
            affiliation:
                  name:Sun Yat-sen University Cancer Center
                  address:
                     name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhuo Cui
            affiliation:
                  name:University of California
                  address:
                     name:Department of Statistics, University of California, Berkeley, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jing He
            affiliation:
                  name:Sun Yat-sen University Cancer Center
                  address:
                     name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Wei-Hua Jia
            affiliation:
                  name:Sun Yat-sen University Cancer Center
                  address:
                     name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Chinese Journal of Cancer
      issn:
         1944-446X
      volumeNumber:34
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Sun Yat-sen University Cancer Center
      address:
         name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
         type:PostalAddress
      name:Harbin Medical University Cancer Hospital
      address:
         name:Molecular Epidemiology Lab and Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin, P. R. China
         type:PostalAddress
      name:Sun Yat-sen University Cancer Center
      address:
         name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
         type:PostalAddress
      name:Sun Yat-sen University Cancer Center
      address:
         name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
         type:PostalAddress
      name:Sun Yat-sen University Cancer Center
      address:
         name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
         type:PostalAddress
      name:University of California
      address:
         name:Department of Statistics, University of California, Berkeley, USA
         type:PostalAddress
      name:Sun Yat-sen University Cancer Center
      address:
         name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
         type:PostalAddress
      name:Sun Yat-sen University Cancer Center
      address:
         name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Shen Chen
      affiliation:
            name:Sun Yat-sen University Cancer Center
            address:
               name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
               type:PostalAddress
            type:Organization
      name:Jin-Hong Zhu
      affiliation:
            name:Harbin Medical University Cancer Hospital
            address:
               name:Molecular Epidemiology Lab and Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin, P. R. China
               type:PostalAddress
            type:Organization
      name:Fang Wang
      affiliation:
            name:Sun Yat-sen University Cancer Center
            address:
               name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
               type:PostalAddress
            type:Organization
      name:Shao-Yi Huang
      affiliation:
            name:Sun Yat-sen University Cancer Center
            address:
               name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
               type:PostalAddress
            type:Organization
      name:Wen-Qiong Xue
      affiliation:
            name:Sun Yat-sen University Cancer Center
            address:
               name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
               type:PostalAddress
            type:Organization
      name:Zhuo Cui
      affiliation:
            name:University of California
            address:
               name:Department of Statistics, University of California, Berkeley, USA
               type:PostalAddress
            type:Organization
      name:Jing He
      affiliation:
            name:Sun Yat-sen University Cancer Center
            address:
               name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Wei-Hua Jia
      affiliation:
            name:Sun Yat-sen University Cancer Center
            address:
               name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
      name:Molecular Epidemiology Lab and Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin, P. R. China
      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
      name:Department of Statistics, University of California, Berkeley, USA
      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China

External Links {🔗}(135)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.52s.

LINK . SPRINGER . COM {}