We are analyzing https://link.springer.com/article/10.1186/s40824-023-00425-3.

Title:
mRNA nanodelivery systems: targeting strategies and administration routes | Biomaterials Research
Description:
With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention and treatment of various refractory diseases. To function efficiently in vivo and overcome clinical limitations, mRNA demands safe and stable vectors and a reasonable administration route, bypassing multiple biological barriers and achieving organ-specific targeted delivery of mRNA. Nanoparticle (NP)-based delivery systems representing leading vector approaches ensure the successful intracellular delivery of mRNA to the target organ. In this review, chemical modifications of mRNA and various types of advanced mRNA NPs, including lipid NPs and polymers are summarized. The importance of passive targeting, especially endogenous targeting, and active targeting in mRNA nano-delivery is emphasized, and different cellular endocytic mechanisms are discussed. Most importantly, based on the above content and the physiological structure characteristics of various organs in vivo, the design strategies of mRNA NPs targeting different organs and cells are classified and discussed. Furthermore, the influence of administration routes on targeting design is highlighted. Finally, an outlook on the remaining challenges and future development toward mRNA targeted therapies and precision medicine is provided. Graphical Abstract
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

mrna, delivery, google, scholar, nps, targeting, cas, cells, administration, lnps, lipid, liver, protein, nanoparticles, cell, cationic, spleen, immune, targeted, target, organs, vivo, lipids, injection, pulmonary, mrnalnps, adv, strategies, drug, deliver, release, polymers, fig, lungs, size, ionizable, mater, zhang, surface, vaccines, active, design, structure, potential, lung, wang, routes, specific, intravenous, efficiency,

Topics {✒️}

n-acetyl-d-galactosamine/asialoglycoprotein receptor pathway 2-di-o-octadecenyl-3-trimethylammonium-propane dspc 2-di-o-octadecenyl-3-trimethylammonium-propane zirconium-based metal-organic framework tetracycline-grafted mpeg-plga micelles 2-distearoyl-sn-glycero-3-phosphocholine fus 2-dioleoyl-sn-glycero-3-phosphoethanolamine dotap 2-dioleoyl-sn‑glycero-3-phosphocholine dope ph-responsive dna nano-hydrogel mrna-based nanodelivery systems microbubble-assisted focused ultrasound ligand-receptor-based active targeting charge-altering releasable transporters yk009-lnp-omicron mrna vaccines atp-responsive polyplex micelles tumor-targeted nano-delivery system bifunctional peptide-modified coronas mannose-conjugated mrna-loaded lnps crispr-cas gene editing full size image capsaicin-loaded chitosan nanocapsules 2-dioleoyl-sn-glycero-3-phosphoethanolamine 2-dioleoyl-sn‑glycero-3-phosphocholine 2-dipalmitoyl-sn-glycero-3-phosphocholine dendritic cell-targeting nanomedicines stimuli-responsive hybridized nanostructures microbubble-assisted fus technology ultrasound-induced bbb opening 2-distearoyl-sn-glycero-3-phosphocholine cationic lipid-assisted nanoparticles metal-organic framework nps universal gsh-responsive nanoplatform organic/inorganic hybrid nps ph-responsive wound dressings peptide-mrna nanoparticles embedded inactivated sars-cov-2 vaccine synthesized 5a2-sc8-mrna-lnps perform anti-tumor functions low-density lipoprotein receptor yk009-lnp-omicron mrna uv-mediated peptide exchange antigen peptide-mhcimolecular complex haematopoietic stem-cell niche galnac-targeted polymer micelle 2-dioleoyl-3-trimethylammonium-propane dotma organocatalytic ring-opening polymerization checkpoint-inhibitor-treated melanoma inorganic nano-platforms remain cpp membrane-penetrating properties intra/extracellular adenosine triphosphate

Questions {❓}

Determinants and implications of mRNA poly(A) tail size–does this protein make my tail look big?
How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?
Nano-delivery to the lung - by inhalation or other routes and why nano when micro is largely sufficient?
Protein corona: friend or foe?
Mucus penetration?

Schema {🗺️}

WebPage:
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         headline:mRNA nanodelivery systems: targeting strategies and administration routes
         description:With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention and treatment of various refractory diseases. To function efficiently in vivo and overcome clinical limitations, mRNA demands safe and stable vectors and a reasonable administration route, bypassing multiple biological barriers and achieving organ-specific targeted delivery of mRNA. Nanoparticle (NP)-based delivery systems representing leading vector approaches ensure the successful intracellular delivery of mRNA to the target organ. In this review, chemical modifications of mRNA and various types of advanced mRNA NPs, including lipid NPs and polymers are summarized. The importance of passive targeting, especially endogenous targeting, and active targeting in mRNA nano-delivery is emphasized, and different cellular endocytic mechanisms are discussed. Most importantly, based on the above content and the physiological structure characteristics of various organs in vivo, the design strategies of mRNA NPs targeting different organs and cells are classified and discussed. Furthermore, the influence of administration routes on targeting design is highlighted. Finally, an outlook on the remaining challenges and future development toward mRNA targeted therapies and precision medicine is provided.
         datePublished:2023-09-22T00:00:00Z
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ScholarlyArticle:
      headline:mRNA nanodelivery systems: targeting strategies and administration routes
      description:With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention and treatment of various refractory diseases. To function efficiently in vivo and overcome clinical limitations, mRNA demands safe and stable vectors and a reasonable administration route, bypassing multiple biological barriers and achieving organ-specific targeted delivery of mRNA. Nanoparticle (NP)-based delivery systems representing leading vector approaches ensure the successful intracellular delivery of mRNA to the target organ. In this review, chemical modifications of mRNA and various types of advanced mRNA NPs, including lipid NPs and polymers are summarized. The importance of passive targeting, especially endogenous targeting, and active targeting in mRNA nano-delivery is emphasized, and different cellular endocytic mechanisms are discussed. Most importantly, based on the above content and the physiological structure characteristics of various organs in vivo, the design strategies of mRNA NPs targeting different organs and cells are classified and discussed. Furthermore, the influence of administration routes on targeting design is highlighted. Finally, an outlook on the remaining challenges and future development toward mRNA targeted therapies and precision medicine is provided.
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         mRNA
         Nanodelivery systems
         Targeting
         Administration routes
         Biomaterials
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      name:Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, China
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      name:Department of Oral and Maxillofacial-Head & Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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