We are analyzing https://link.springer.com/article/10.1186/s40169-019-0237-6.

Title:
The role of liver microenvironment in hepatic metastasis | Clinical and Translational Medicine
Description:
Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delegation of metastasis, expanding the field of cancer metastasis to cells and cell environments surrounding the migrated tumor cells. Research on hepatic metastasis is an ever-growing domain of this field, as several primary tumors can metastasize to the liver. The two features within the liver that promote metastasis—cellular and acellular—are found in the current interpretation of liver microenvironment. Novel findings of both are included in this review. Different hypotheses detailing the methods by which metastasis can occur must be included to understand the significance of the microenvironment, as well as a brief overview of the methods that can be used during research. This review aims to highlight the importance of liver microenvironment on the development or potential regression of hepatic metastasis through discussing both acellular and cellular components of liver microenvironment and their interaction with metastasis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

metastasis, cells, liver, pubmed, cancer, article, tumor, google, scholar, microenvironment, cas, cell, growth, hepatic, central, metastatic, role, proteins, factor, components, collagen, colorectal, study, cellular, matrix, ecm, metastases, kcs, immune, pancreatic, acellular, emt, research, review, promote, contribute, patients, macrophages, transition, factors, kupffer, endothelial, vegf, niche, signaling, formation, models, stem, data, provide,

Topics {✒️}

nuclear factor kappa-light-chain-enhancer article download pdf serum-derived carcinoembryonic antigen myeloid-derived suppressor cells α-smooth muscle actin bone-marrow-derived macrophages organ-specific metastases obtained targeting igf-ir therapy hepatic stellate cells cea-expressing tumor cells tissue-specific decellularized scaffolds metastatic niche formation privacy choices/manage cookies regulate tumor metastasis hepatocyte growth factor hypoxia-inducing factor-1 cell adhesion molecules cells tgf-β pancreatic ductal adenocarcinoma direct proliferative measures colon cancer cells pdac-derived exosomes highly vascular nature hsc-derived factors natural killer cells cancer stem cells disseminated tumor cells regulatory transcription factor cancer cell cultures organ systems external pretumoral pancreatic lesions colorectal cancer metastasis promotes cell migration major cellular components igf-ir signaling individual cells detected article williamson cell environments surrounding tumour cell lines related subjects colorectal liver metastasis major acellular components primary breast tumor tumor-activated forms pro-metastatic functions circulating tumour cells spermine pullulan play opposing roles migrated tumor cells circulating tumor cells

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The role of liver microenvironment in hepatic metastasis
         description:Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delegation of metastasis, expanding the field of cancer metastasis to cells and cell environments surrounding the migrated tumor cells. Research on hepatic metastasis is an ever-growing domain of this field, as several primary tumors can metastasize to the liver. The two features within the liver that promote metastasis—cellular and acellular—are found in the current interpretation of liver microenvironment. Novel findings of both are included in this review. Different hypotheses detailing the methods by which metastasis can occur must be included to understand the significance of the microenvironment, as well as a brief overview of the methods that can be used during research. This review aims to highlight the importance of liver microenvironment on the development or potential regression of hepatic metastasis through discussing both acellular and cellular components of liver microenvironment and their interaction with metastasis.
         datePublished:2019-07-01T00:00:00Z
         dateModified:2019-07-01T00:00:00Z
         pageStart:1
         pageEnd:7
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1186/s40169-019-0237-6
         keywords:
            Cancer
            Tumor
            CTC
            ECM
            Metastatic
            Medicine/Public Health
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs40169-019-0237-6/MediaObjects/40169_2019_237_Fig1_HTML.png
         isPartOf:
            name:Clinical and Translational Medicine
            issn:
               2001-1326
            volumeNumber:8
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Tovah Williamson
               affiliation:
                     name:UNC School of Medicine
                     address:
                        name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nikhila Sultanpuram
               affiliation:
                     name:UNC School of Medicine
                     address:
                        name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hossein Sendi
               url:http://orcid.org/0000-0002-1054-6571
               affiliation:
                     name:UNC School of Medicine
                     address:
                        name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
                        type:PostalAddress
                     type:Organization
                     name:UNC School of Pharmacy
                     address:
                        name:Center for Nanotechnology in Drug Delivery, UNC School of Pharmacy, Chapel Hill, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The role of liver microenvironment in hepatic metastasis
      description:Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delegation of metastasis, expanding the field of cancer metastasis to cells and cell environments surrounding the migrated tumor cells. Research on hepatic metastasis is an ever-growing domain of this field, as several primary tumors can metastasize to the liver. The two features within the liver that promote metastasis—cellular and acellular—are found in the current interpretation of liver microenvironment. Novel findings of both are included in this review. Different hypotheses detailing the methods by which metastasis can occur must be included to understand the significance of the microenvironment, as well as a brief overview of the methods that can be used during research. This review aims to highlight the importance of liver microenvironment on the development or potential regression of hepatic metastasis through discussing both acellular and cellular components of liver microenvironment and their interaction with metastasis.
      datePublished:2019-07-01T00:00:00Z
      dateModified:2019-07-01T00:00:00Z
      pageStart:1
      pageEnd:7
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1186/s40169-019-0237-6
      keywords:
         Cancer
         Tumor
         CTC
         ECM
         Metastatic
         Medicine/Public Health
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs40169-019-0237-6/MediaObjects/40169_2019_237_Fig1_HTML.png
      isPartOf:
         name:Clinical and Translational Medicine
         issn:
            2001-1326
         volumeNumber:8
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Tovah Williamson
            affiliation:
                  name:UNC School of Medicine
                  address:
                     name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nikhila Sultanpuram
            affiliation:
                  name:UNC School of Medicine
                  address:
                     name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hossein Sendi
            url:http://orcid.org/0000-0002-1054-6571
            affiliation:
                  name:UNC School of Medicine
                  address:
                     name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
                     type:PostalAddress
                  type:Organization
                  name:UNC School of Pharmacy
                  address:
                     name:Center for Nanotechnology in Drug Delivery, UNC School of Pharmacy, Chapel Hill, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Clinical and Translational Medicine
      issn:
         2001-1326
      volumeNumber:8
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:UNC School of Medicine
      address:
         name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
         type:PostalAddress
      name:UNC School of Medicine
      address:
         name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
         type:PostalAddress
      name:UNC School of Medicine
      address:
         name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
         type:PostalAddress
      name:UNC School of Pharmacy
      address:
         name:Center for Nanotechnology in Drug Delivery, UNC School of Pharmacy, Chapel Hill, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Tovah Williamson
      affiliation:
            name:UNC School of Medicine
            address:
               name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      name:Nikhila Sultanpuram
      affiliation:
            name:UNC School of Medicine
            address:
               name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      name:Hossein Sendi
      url:http://orcid.org/0000-0002-1054-6571
      affiliation:
            name:UNC School of Medicine
            address:
               name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
               type:PostalAddress
            type:Organization
            name:UNC School of Pharmacy
            address:
               name:Center for Nanotechnology in Drug Delivery, UNC School of Pharmacy, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
      name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
      name:Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, USA
      name:Center for Nanotechnology in Drug Delivery, UNC School of Pharmacy, Chapel Hill, USA

External Links {🔗}(163)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.71s.

LINK . SPRINGER . COM {}