We are analyzing https://link.springer.com/article/10.1186/s13287-021-02321-w.

Title:
Signaling pathways governing breast cancer stem cells behavior | Stem Cell Research & Therapy
Description:
Breast cancer is the second common cancer and the leading cause of malignancy among females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that play a critical role in the metastasis of breast cancer to other organs in the body. BCSCs have both self-renewal and differentiation capacities, which are thought to contribute to the aggressiveness of metastatic lesions. Therefore, targeting BCSCs can be a suitable approach for the treatment and metastasis of breast cancer. Growing evidence has indicated that the Wnt, NFκB, Notch, BMP2, STAT3, and hedgehog (Hh) signaling pathways govern epithelial-to-mesenchymal transition (EMT) activation, growth, and tumorigenesis of BCSCs in the primary regions. miRNAs as the central regulatory molecules also play critical roles in BCSC self-renewal, metastasis, and drug resistance. Hence, targeting these pathways might be a novel therapeutic approach for breast cancer diagnosis and therapy. This review discusses known signaling mechanisms involved in the stimulation or prevention of BCSC self-renewal, metastasis, and tumorigenesis.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

cancer, pubmed, breast, article, google, scholar, cas, cells, stem, bcscs, central, signaling, cell, bcsc, targeting, pathway, metastasis, pathways, wang, zhang, wnt, growth, factor, resistance, expression, role, res, therapeutic, proliferation, tumorigenesis, protein, emt, stemness, targets, liu, selfrenewal, receptor, tumor, oncol, therapy, notch, inhibits, chen, target, wntβcatenin, human, med, hedgehog, drug, mol,

Topics {✒️}

sustained akt/nf-κb/cox-2 activation wnt/β-catenin/tcf4 axis wnt/β-catenin signaling pathway blocks wnt/β-catenin signaling tet-family-dependent chromatin remodeling e-cadherin/β-catenin complex targeting wnt/β-catenin signaling pi3k/akt/mtor pathway inhibitor article download pdf fluorescence-activated cell sorting breast cancer-initiating cells breast-cancer stem cells perinatology research center triple-negative breast cancer mir-130a-3p inhibits migration zinc-finger transcription factor wnt/β-catenin signaling integrin β3/wnt signaling cytoplasmic β-catenin antagonists cd44-/low/cd24-/low cells wnt/β-catenin pathway ras/raf/mek/ek mir-519d impedes cisplatin-resistance estrogen-activated wnt signaling inter-tumor genomic heterogeneity secreted frizzled-related proteins targeting β-catenin pathway developmental stage-specific contribution targeting metastasis-initiating cells her2/neu mouse model including wnt/β-catenin tamoxifen-resistant breast cancer drug-resistant breast cancer propensity score–matched update key signaling pathways enhance nuclear β-catenin triple-negative breast cancers aldh1 stem-cell markers central regulatory molecules notch-hes1-cyclin d1 febs open bio pi3k/akt/mtor inhibitors wnt1/abcb1 pathway promotes paracrine fgf/tbx3 signaling cancer stem cells er/pr positive type stat3/hif-1 signaling pathways full size image mir-29a represses suv420h2 breast cancer stem

Questions {❓}

Targeting CD36 as biomarker for metastasis prognostic: how far from translation into clinical practice?

Schema {🗺️}

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         description:Breast cancer is the second common cancer and the leading cause of malignancy among females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that play a critical role in the metastasis of breast cancer to other organs in the body. BCSCs have both self-renewal and differentiation capacities, which are thought to contribute to the aggressiveness of metastatic lesions. Therefore, targeting BCSCs can be a suitable approach for the treatment and metastasis of breast cancer. Growing evidence has indicated that the Wnt, NFκB, Notch, BMP2, STAT3, and hedgehog (Hh) signaling pathways govern epithelial-to-mesenchymal transition (EMT) activation, growth, and tumorigenesis of BCSCs in the primary regions. miRNAs as the central regulatory molecules also play critical roles in BCSC self-renewal, metastasis, and drug resistance. Hence, targeting these pathways might be a novel therapeutic approach for breast cancer diagnosis and therapy. This review discusses known signaling mechanisms involved in the stimulation or prevention of BCSC self-renewal, metastasis, and tumorigenesis.
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      headline:Signaling pathways governing breast cancer stem cells behavior
      description:Breast cancer is the second common cancer and the leading cause of malignancy among females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that play a critical role in the metastasis of breast cancer to other organs in the body. BCSCs have both self-renewal and differentiation capacities, which are thought to contribute to the aggressiveness of metastatic lesions. Therefore, targeting BCSCs can be a suitable approach for the treatment and metastasis of breast cancer. Growing evidence has indicated that the Wnt, NFκB, Notch, BMP2, STAT3, and hedgehog (Hh) signaling pathways govern epithelial-to-mesenchymal transition (EMT) activation, growth, and tumorigenesis of BCSCs in the primary regions. miRNAs as the central regulatory molecules also play critical roles in BCSC self-renewal, metastasis, and drug resistance. Hence, targeting these pathways might be a novel therapeutic approach for breast cancer diagnosis and therapy. This review discusses known signaling mechanisms involved in the stimulation or prevention of BCSC self-renewal, metastasis, and tumorigenesis.
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