We are analyzing https://link.springer.com/article/10.1186/s13287-018-0979-x.

Title:
Mesenchymal stem cells alleviate experimental autoimmune cholangitis through immunosuppression and cytoprotective function mediated by galectin-9 | Stem Cell Research & Therapy
Description:
Background Mesenchymal stem cells (MSCs) play an anti-inflammatory role by secreting certain bioactive molecules to exert their therapeutic effects for disease treatment. However, the underlying mechanism of MSCs in chronic autoimmune liver diseases—primary biliary cholangitis (PBC), for example—remains to be elucidated. Methods Human umbilical cord–derived MSCs (UC-MSCs) were injected intravenously into 2-octynoic acid coupled to bovine serum albumin (2OA-BSA)-induced autoimmune cholangitis mice. Serum levels of biomarkers and autoantibodies, histologic changes in the liver, diverse CD4+ T-cell subsets in different tissues, and chemokine activities were analyzed. Moreover, we investigated galectin-9 (Gal-9) expression and its function in UC-MSCs. Results In this study, UC-MSC transplantation (UC-MSCT) significantly ameliorated liver inflammation, primarily by diminishing T helper 1 (Th1) and Th17 responses as well as modifying liver chemokine activities in experimental autoimmune cholangitis mice. Mechanistically, UC-MSCs significantly repressed the proliferation of CD4+ T cells and suppressed the differentiation of Th1 and Th17 cells, which was likely dependent on Gal-9. Furthermore, the signal transducer and activator of transcription (STAT) and c-Jun N-terminal kinase (JNK) signaling pathways were involved in the production of Gal-9 in UC-MSCs. Conclusions These results suggest that Gal-9 contributes significantly to UC-MSC–mediated therapeutic effects and improve our understanding of the immunomodulatory mechanisms of MSCs in the treatment of PBC.
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Keywords {🔍}

cells, ucmscs, article, gal, stem, cell, google, scholar, mesenchymal, cas, liver, cholangitis, expression, biliary, ucmsct, primary, pbc, umbilical, mice, galectin, ifnγ, autoimmune, cordderived, fig, serum, usa, mscs, stat, wang, blood, effects, study, transplantation, significantly, responses, sem, represent, data, zhang, treatment, jnk, bars, figure, chemokines, therapeutic, acid, proliferation, signaling, immunol, human,

Topics {✒️}

c-jun n-terminal kinase umbilical cord-derived msc 2oa-bsa–induced autoimmune cholangitis plv-cmv-gfp-neo vector p38/mitogen-activated protein kinase 20 ng/ml phorbol-12-myristate-13-acetate diverse cd4+ t-cell subsets bile duct damage hepatic mrna expression type-ii-interferon-mediated signalling suppress cd4+ t-cell proliferation combined cancer therapy disease-stage-based approach mesenchymal stem cells serum anti-pdc-e2 autoantibodies extracellular-regulated protein kinase cell stem cell 5 μg/ml anti-ifn-γ enzyme-linked immunosorbent assay induced autoimmune cholangitis suppress t-cell proliferation uc-msc–derived gal-9 primary biliary cholangitis double-positive yellow cells ifn-γ effectively activated including bone marrow /ml penicillin/streptomycin solution uc-msc conditioned media article download pdf lipoic acid-lysine located induce cross-species immunoreaction mesenchymal stromal cells umbilical cord beta-galactoside–binding proteins chemokine-chemokine receptor network 5 μg/ml anti-cd3 5 μg/ml anti-cd28 uc-msc–mediated therapeutic effects cd4+ t-cell proliferation ifn-γ–induced gal-9 expression 100 μg 2oa-bsa conjugate anti-pdc-e2 antibody conjugated anti-rabbit igg anti-pdc-e2 autoantibodies collagen-induced arthritis stem cell technologies exert anti-inflammatory actions mouse anti-gapdh antibody liver-infiltrating mononuclear cells interlobular bile ducts

Questions {❓}

Mesenchymal stem cell treatments in rheumatology: a glass half full?
Mesenchymal stromal cells and regulatory T cells: the yin and Yang of peripheral tolerance?
Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?

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