We are analyzing https://link.springer.com/article/10.1186/s13073-021-00833-x.

Title:
5′-tRF-GlyGCC: a tRNA-derived small RNA as a novel biomarker for colorectal cancer diagnosis | Genome Medicine
Description:
Background tRNA-derived small RNAs (tDRs), which are widely distributed in human tissues including blood and urine, play an important role in the progression of cancer. However, the expression of tDRs in colorectal cancer (CRC) plasma and their potential diagnostic values have not been systematically explored. Methods The expression profiles of tDRs in plasma of CRC and health controls (HCs) are investigated by small RNA sequencing. The level and diagnostic value of 5′-tRF-GlyGCC are evaluated by quantitative PCR in plasma samples from 105 CRC patients and 90 HCs. The mechanisms responsible for biogenesis of 5′-tRF-GlyGCC are checked by in vitro and in vivo models. Results 5′-tRF-GlyGCC is dramatically increased in plasma of CRC patients compared to that of HCs. The area under curve (AUC) for 5′-tRF-GlyGCC in CRC group is 0.882. The combination of carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199) with 5′-tRF-GlyGCC improves the AUC to 0.926. Consistently, the expression levels of 5′-tRF-GlyGCC in CRC cells and xenograft tissues are significantly greater than that in their corresponding controls. Blood cells co-cultured with CRC cells or mice xenografted with CRC tumors show increased levels of 5′-tRF-GlyGCC. In addition, we find that the increased expression of 5′-tRF-GlyGCC is dependent on the upregulation of AlkB homolog 3 (ALKBH3), a tRNA demethylase which can promote tRNA cleaving to generate tDRs. Conclusions The level of 5′-tRF-GlyGCC in plasma is a promising diagnostic biomarker for CRC diagnosis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

crc, trfglygcc, plasma, cells, patients, expression, alkbh, cancer, fig, article, pubmed, tdrs, google, scholar, levels, rna, cas, small, cell, human, mice, data, blood, hcs, diagnosis, increased, significantly, trnaderived, colorectal, showed, biomarker, trf, pengebv, wang, rnas, results, cea, biomarkers, stage, study, hct, yang, trna, sun, tumor, central, progression, diagnostic, zhang, samples,

Topics {✒️}

balb/c-nu-nu mice trna-derived small rnas tumour-educated circulating monocytes trna-derived small rna transfer rna-derived fragments trna-derived rna fragments serum trna-derived fragments aminoacyl-trna ester bond leucine-rich α-2-glycoprotein 1 il-7/stat5/socs pathways tweak/fn14/vegf signals article download pdf view trna-derived small sun yat-sen university triple-negative breast cancer trna-derived fragments small-cell lung cancer peng-ebv cells pre-transfected 150 μl pbs + 150 μl matrigel lymphocyte peng-ebv cells 5′-trf-glyccc markedly increased original author western blot analysis transfer rna fragments peng-ebv cells induced trf-gly-gcc-037 high-diagnostic efficacy biomarker 17-nt fragment derived blood peng-ebv cells fecal occult blood crc-induced 5′-trf-glygcc small rna sequencing privacy choices/manage cookies 10 μl rna/125 μl plasma cancer cell proliferation interval colorectal cancer fecal immunochemical test full access colorectal-cancer screening expression profile increasing cell proliferation fundamental research funds tdrs including 5′-trf-glygcc hongsheng wang 5′-trf-glygcc significantly increased tumor-bearing mice tumor bearing mice invasive screening tests plasma 5′-trf-glygcc content

Schema {🗺️}

WebPage:
      mainEntity:
         headline:5′-tRF-GlyGCC: a tRNA-derived small RNA as a novel biomarker for colorectal cancer diagnosis
         description:tRNA-derived small RNAs (tDRs), which are widely distributed in human tissues including blood and urine, play an important role in the progression of cancer. However, the expression of tDRs in colorectal cancer (CRC) plasma and their potential diagnostic values have not been systematically explored. The expression profiles of tDRs in plasma of CRC and health controls (HCs) are investigated by small RNA sequencing. The level and diagnostic value of 5′-tRF-GlyGCC are evaluated by quantitative PCR in plasma samples from 105 CRC patients and 90 HCs. The mechanisms responsible for biogenesis of 5′-tRF-GlyGCC are checked by in vitro and in vivo models. 5′-tRF-GlyGCC is dramatically increased in plasma of CRC patients compared to that of HCs. The area under curve (AUC) for 5′-tRF-GlyGCC in CRC group is 0.882. The combination of carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199) with 5′-tRF-GlyGCC improves the AUC to 0.926. Consistently, the expression levels of 5′-tRF-GlyGCC in CRC cells and xenograft tissues are significantly greater than that in their corresponding controls. Blood cells co-cultured with CRC cells or mice xenografted with CRC tumors show increased levels of 5′-tRF-GlyGCC. In addition, we find that the increased expression of 5′-tRF-GlyGCC is dependent on the upregulation of AlkB homolog 3 (ALKBH3), a tRNA demethylase which can promote tRNA cleaving to generate tDRs. The level of 5′-tRF-GlyGCC in plasma is a promising diagnostic biomarker for CRC diagnosis.
         datePublished:2021-02-09T00:00:00Z
         dateModified:2021-02-09T00:00:00Z
         pageStart:1
         pageEnd:12
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13073-021-00833-x
         keywords:
             5′-tRF-GlyGCC
            CRC
            ALKBH3
            Plasma
            tRNA-derived small RNAs
            Human Genetics
            Metabolomics
            Bioinformatics
            Medicine/Public Health
            general
            Cancer Research
            Systems Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig6_HTML.png
         isPartOf:
            name:Genome Medicine
            issn:
               1756-994X
            volumeNumber:13
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yingmin Wu
               affiliation:
                     name:Sun Yat-sen University
                     address:
                        name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiangling Yang
               affiliation:
                     name:The Sixth Affiliated Hospital, Sun Yat-sen University
                     address:
                        name:Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
                     name:The Sixth Affiliated Hospital, Sun Yat-sen University
                     address:
                        name:Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Guanmin Jiang
               affiliation:
                     name:The Fifth Affiliated Hospital, Sun Yat-sen University
                     address:
                        name:Department of Clinical Laboratory, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Haisheng Zhang
               affiliation:
                     name:Sun Yat-sen University
                     address:
                        name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lichen Ge
               affiliation:
                     name:Medical School of Nanjing University
                     address:
                        name:Department of Clinical Laboratory, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Feng Chen
               affiliation:
                     name:Sun Yat-sen University
                     address:
                        name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jiexin Li
               affiliation:
                     name:Sun Yat-sen University
                     address:
                        name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Huanliang Liu
               affiliation:
                     name:The Sixth Affiliated Hospital, Sun Yat-sen University
                     address:
                        name:Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
                     name:The Sixth Affiliated Hospital, Sun Yat-sen University
                     address:
                        name:Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Hongsheng Wang
               url:http://orcid.org/0000-0002-0054-4820
               affiliation:
                     name:Sun Yat-sen University
                     address:
                        name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:5′-tRF-GlyGCC: a tRNA-derived small RNA as a novel biomarker for colorectal cancer diagnosis
      description:tRNA-derived small RNAs (tDRs), which are widely distributed in human tissues including blood and urine, play an important role in the progression of cancer. However, the expression of tDRs in colorectal cancer (CRC) plasma and their potential diagnostic values have not been systematically explored. The expression profiles of tDRs in plasma of CRC and health controls (HCs) are investigated by small RNA sequencing. The level and diagnostic value of 5′-tRF-GlyGCC are evaluated by quantitative PCR in plasma samples from 105 CRC patients and 90 HCs. The mechanisms responsible for biogenesis of 5′-tRF-GlyGCC are checked by in vitro and in vivo models. 5′-tRF-GlyGCC is dramatically increased in plasma of CRC patients compared to that of HCs. The area under curve (AUC) for 5′-tRF-GlyGCC in CRC group is 0.882. The combination of carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199) with 5′-tRF-GlyGCC improves the AUC to 0.926. Consistently, the expression levels of 5′-tRF-GlyGCC in CRC cells and xenograft tissues are significantly greater than that in their corresponding controls. Blood cells co-cultured with CRC cells or mice xenografted with CRC tumors show increased levels of 5′-tRF-GlyGCC. In addition, we find that the increased expression of 5′-tRF-GlyGCC is dependent on the upregulation of AlkB homolog 3 (ALKBH3), a tRNA demethylase which can promote tRNA cleaving to generate tDRs. The level of 5′-tRF-GlyGCC in plasma is a promising diagnostic biomarker for CRC diagnosis.
      datePublished:2021-02-09T00:00:00Z
      dateModified:2021-02-09T00:00:00Z
      pageStart:1
      pageEnd:12
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13073-021-00833-x
      keywords:
          5′-tRF-GlyGCC
         CRC
         ALKBH3
         Plasma
         tRNA-derived small RNAs
         Human Genetics
         Metabolomics
         Bioinformatics
         Medicine/Public Health
         general
         Cancer Research
         Systems Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13073-021-00833-x/MediaObjects/13073_2021_833_Fig6_HTML.png
      isPartOf:
         name:Genome Medicine
         issn:
            1756-994X
         volumeNumber:13
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yingmin Wu
            affiliation:
                  name:Sun Yat-sen University
                  address:
                     name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiangling Yang
            affiliation:
                  name:The Sixth Affiliated Hospital, Sun Yat-sen University
                  address:
                     name:Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:The Sixth Affiliated Hospital, Sun Yat-sen University
                  address:
                     name:Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Guanmin Jiang
            affiliation:
                  name:The Fifth Affiliated Hospital, Sun Yat-sen University
                  address:
                     name:Department of Clinical Laboratory, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Haisheng Zhang
            affiliation:
                  name:Sun Yat-sen University
                  address:
                     name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lichen Ge
            affiliation:
                  name:Medical School of Nanjing University
                  address:
                     name:Department of Clinical Laboratory, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Feng Chen
            affiliation:
                  name:Sun Yat-sen University
                  address:
                     name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jiexin Li
            affiliation:
                  name:Sun Yat-sen University
                  address:
                     name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Huanliang Liu
            affiliation:
                  name:The Sixth Affiliated Hospital, Sun Yat-sen University
                  address:
                     name:Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:The Sixth Affiliated Hospital, Sun Yat-sen University
                  address:
                     name:Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Hongsheng Wang
            url:http://orcid.org/0000-0002-0054-4820
            affiliation:
                  name:Sun Yat-sen University
                  address:
                     name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Genome Medicine
      issn:
         1756-994X
      volumeNumber:13
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Sun Yat-sen University
      address:
         name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
         type:PostalAddress
      name:The Sixth Affiliated Hospital, Sun Yat-sen University
      address:
         name:Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
         type:PostalAddress
      name:The Sixth Affiliated Hospital, Sun Yat-sen University
      address:
         name:Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
         type:PostalAddress
      name:The Fifth Affiliated Hospital, Sun Yat-sen University
      address:
         name:Department of Clinical Laboratory, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China
         type:PostalAddress
      name:Sun Yat-sen University
      address:
         name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
         type:PostalAddress
      name:Medical School of Nanjing University
      address:
         name:Department of Clinical Laboratory, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
         type:PostalAddress
      name:Sun Yat-sen University
      address:
         name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
         type:PostalAddress
      name:Sun Yat-sen University
      address:
         name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
         type:PostalAddress
      name:The Sixth Affiliated Hospital, Sun Yat-sen University
      address:
         name:Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
         type:PostalAddress
      name:The Sixth Affiliated Hospital, Sun Yat-sen University
      address:
         name:Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
         type:PostalAddress
      name:Sun Yat-sen University
      address:
         name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yingmin Wu
      affiliation:
            name:Sun Yat-sen University
            address:
               name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Xiangling Yang
      affiliation:
            name:The Sixth Affiliated Hospital, Sun Yat-sen University
            address:
               name:Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
            name:The Sixth Affiliated Hospital, Sun Yat-sen University
            address:
               name:Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Guanmin Jiang
      affiliation:
            name:The Fifth Affiliated Hospital, Sun Yat-sen University
            address:
               name:Department of Clinical Laboratory, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China
               type:PostalAddress
            type:Organization
      name:Haisheng Zhang
      affiliation:
            name:Sun Yat-sen University
            address:
               name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Lichen Ge
      affiliation:
            name:Medical School of Nanjing University
            address:
               name:Department of Clinical Laboratory, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Feng Chen
      affiliation:
            name:Sun Yat-sen University
            address:
               name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Jiexin Li
      affiliation:
            name:Sun Yat-sen University
            address:
               name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Huanliang Liu
      affiliation:
            name:The Sixth Affiliated Hospital, Sun Yat-sen University
            address:
               name:Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
            name:The Sixth Affiliated Hospital, Sun Yat-sen University
            address:
               name:Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Hongsheng Wang
      url:http://orcid.org/0000-0002-0054-4820
      affiliation:
            name:Sun Yat-sen University
            address:
               name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
      name:Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
      name:Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
      name:Department of Clinical Laboratory, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China
      name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
      name:Department of Clinical Laboratory, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
      name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
      name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
      name:Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
      name:Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
      name:Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China

External Links {🔗}(181)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.48s.

LINK . SPRINGER . COM {}