We are analyzing https://link.springer.com/article/10.1186/s13059-022-02674-2.

Title:
Non-AUG translation initiation in mammals | Genome Biology
Description:
Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes.
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Keywords {🔍}

pubmed, initiation, translation, article, nonaug, google, scholar, cas, central, codon, codons, eif, start, aug, protein, rna, cell, ribosome, mrna, downstream, factor, biol, scanning, upstream, eukaryotic, context, elongation, selection, human, factors, cug, regulation, open, mrnas, mol, proteoforms, reading, cells, nucleotide, recognition, tiss, uorfs, specific, fig, res, ribosomes, mammalian, mechanism, ribosomal, efficient,

Topics {✒️}

aug-initiated n-terminal extensions enhances oestrogen-dependent transcription amp-activated protein kinase p-site enables met-trnai n-terminal protein extensions noncanonical dna-binding site human eif5-mimic protein human bag-1/rap46 protein article download pdf eif1/bzw/eif5 “stringency” factors mckusick-kaufman syndrome transcript upstream orf-encoded asdurf n-terminally extended myc yield n-terminally extended s-adenosylmethionine decarboxylase mrna n-terminally distinct protein site-specific ribosomal pauses n-terminally extended proteoform dual-coding gene mief1 related subjects confirming dinesh-kumar polyproline-specific tripeptide sequences ribosome pre-initiation complex promote start-codon recognition ca2+/calmodulin-dependent phosphorylation evolutionary selection acting full access ribosome p-site close sui/sui alleles eif5a-dependent pause site full size image enabling gene-specific regulation main aug-initiated orf describes transcriptome-wide regulation single aug-initiated orf protein-specific translation control rna binding proteins aug-initiated protein isoforms cognate charged trnas start codon selection human sorf-encoded polypeptides cug-initiated protein polgarf todd pk aug-initiated short uorf c-terminal domain aug initiation transcriptome-wide helicase ded1p controls alternative reading frames standard cap-dependent mechanism n-terminal domain

Questions {❓}

How do eucaryotic ribosomes select initiation regions in messenger RNA?
What are the functional and phenotypic consequences of translation of these sORFs?
Why is start codon selection so precise in eukaryotes?

Schema {🗺️}

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         description:Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes.
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      description:Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes.
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         Human Genetics
         Plant Genetics and Genomics
         Microbial Genetics and Genomics
         Bioinformatics
         Evolutionary Biology
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      name:School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland
      name:School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland
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      name:Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
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