We are analyzing https://link.springer.com/article/10.1186/s12943-021-01322-w.

Title:
Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer | Molecular Cancer
Description:
Background The four major RNA adenosine modifications, i.e., m6A, m1A, alternative polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” enzymes and constitute critical mechanisms of epigenetic regulation in immune response and tumorigenesis. However, the cross-talk and potential roles of these “writers” in the tumor microenvironment (TME), drug sensitivity, and immunotherapy remain unknown. Methods We systematically characterized mRNA expression and genetic alterations of 26 RNA modification “writers” in colorectal cancer (CRC), and evaluated their expression pattern in 1697 CRC samples from 8 datasets. We used an unsupervised clustering method to assign the samples into two patterns of expression of RNA modification “writers”. Subsequently, we constructed the RNA modification “writer” Score (WM_Score) model based on differentially expressed genes (DEGs) responsible for the RNA modification patterns to quantify the RNA modification-related subtypes of individual tumors. Furthermore, we performed association analysis for WM_Score and characteristics of TME, consensus molecular subtypes (CMSs), clinical features, transcriptional and post-transcriptional regulation, drug response, and the efficacy of immunotherapy. Results We demonstrated that multi-layer alterations of RNA modification “writer” are associated with patient survival and TME cell-infiltrating characteristics. We identified two distinct RNA modification patterns, characterized by a high and a low WM_Score. The WM_Score-high group was associated with worse patient overall survival and with the infiltration of inhibitory immune cells, such as M2 macrophages, EMT activation, and metastasis, while the WM_Score-low group was associated with a survival advantage, apoptosis, and cell cycle signaling pathways. WM_Score correlated highly with the regulation of transcription and post-transcriptional events contributing to the development of CRC. In response to anti-cancer drugs, WM_Score highly negatively correlated (drug sensitive) with drugs which targeted oncogenic related pathways, such as MAPK, EGFR, and mTOR signaling pathways, positively correlated (drug resistance) with drugs which targeted in apoptosis and cell cycle. Importantly, the WM_Score was associated with the therapeutic efficacy of PD-L1 blockade, suggesting that the development of potential drugs targeting these “writers” to aid the clinical benefits of immunotherapy. Conclusions Our study is the first to provide a comprehensive analysis of four RNA modifications in CRC. We revealed the potential function of these writers in TME, transcriptional and post-transcriptional events, and identified their therapeutic liability in targeted therapy and immunotherapy. This work highlights the cross-talk and potential clinical utility of RNA modification “writers” in cancer therapy.
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Keywords {🔍}

rna, modification, wmscore, cancer, pubmed, crc, article, writers, google, scholar, expression, cas, fig, analysis, cell, genes, signaling, editing, cells, patients, immune, survival, pathways, wmscorehigh, group, gene, tumor, cohort, low, samples, patterns, test, cluster, central, drug, cohorts, emt, table, difference, clinical, infiltration, gse, wmscorelow, figure, enrichment, significantly, groups, subtypes, cms, response,

Topics {✒️}

youqiong ye & hua-bing li il6/jak/stat3 signaling pathway jak/stat3/socs3 signaling pathway jak3/stat3/socs3 pathway trna-derived small rnas anti-pd-l1 cohort downloaded transforming growth factor-beta hua-bing li cancer-relevant splicing networks n6-methyladenosines modulate a kaplan-meier curves show anti-pd-l1 antibody kaplan-meier curves comparing exploratory multi-omic analysis anti-pd-l1 blocker article download pdf nf-κb pathway gene full size image tgf-β-driven program anti-pd-l1 cohorts il-7/stat5/socs pathways anti-pd-l1 cohort oxford university press tcga-coad/read cohorts tcga coad/read cohorts tgf-β signaling pathway chi-squared test performed anti-pd-l1 immunotherapy sided log-rank test tcga-coad/read cohort anti-pd-l1 treatment checkpoint inhibitor-based immunotherapy time-dependent roc curves box plots show pd-l1 blockade immunotherapy tgf-β induces emt kaplan-meier curves compare rna modification-related subtypes rna-modification-related subtypes cox regression analysis studied emt-related cytokine tgf-β tumor suppression 159 tcga-read/coad samples dna damage repair k-means clustering algorithm cancer-immune set point prominent tgf-β activation support vector regression cms4-related signaling pathways regulate post-transcriptional events

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            Tumor microenvironment
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      name:Youqiong Ye
      affiliation:
            name:Shanghai Jiao Tong University School of Medicine
            address:
               name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Hua-Bing Li
      url:http://orcid.org/0000-0003-3573-6803
      affiliation:
            name:Shanghai Jiao Tong University School of Medicine
            address:
               name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
               type:PostalAddress
            type:Organization
            name:Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine
            address:
               name:Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, China
               type:PostalAddress
            type:Organization
            name:Shanghai Jiao Tong University School of Medicine
            address:
               name:Department of Liver Surgery, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:The Charles Perkins Centre, University of Sydney, Sydney, Australia
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Department of Liver Surgery, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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