We are analyzing https://link.springer.com/article/10.1186/s12915-016-0262-5.

Title:
No title found...
Description:
Background Programmed cell deaths in the nematode Caenorhabditis elegans are generally considered suicides. Dying cells are engulfed by neighboring cells in a process of phagocytosis. To better understand the interaction between the engulfment and death processes, we analyzed B.al/rapaav cell death, which has been previously described as engulfment-dependent and hence as a possible murder. Results We found that B.al/rapaav is resistant to caspase-pathway activation: the caspase-mediated suicide pathway initiates the cell-death process but is insufficient to cause B.al/rapaav death without the subsequent assistance of engulfment. When the engulfing cell P12.pa is absent, other typically non-phagocytic cells can display cryptic engulfment potential and facilitate this death. Conclusions We term this death an “assisted suicide” and propose that assisted suicides likely occur in other organisms. The study of assisted suicides might provide insight into non-cell autonomous influences on cell death. Understanding the mechanism that causes B.al/rapaav to be resistant to activation of the caspase pathway might reveal the basis of differences in the sensitivity to apoptotic stimuli of tumor and normal cells, a key issue in the field of cancer therapeutics.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Telecommunications
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

balrapaav, cell, death, engulfment, ced, cells, animals, ppa, egl, suicide, mutants, nis, fig, pubmed, elegans, article, genes, google, scholar, celldeath, balapaav, stage, cas, larval, engulfed, barapaav, dying, programmed, process, fourth, homolog, engulfing, animal, data, pathway, xnlsgfp, undead, caenorhabditis, evl, required, horvitz, deaths, additional, mcherryph, wildtype, hime, assisted, file, expressed, expression,

Topics {✒️}

mid-fourth larval stage article download pdf orca-er ccd camera short pro-apoptotic isoform regulates cell-death genes post-embryonic cell lineages fourth larval stage cell-death mutant backgrounds average background intensity core cell-death pathway elegans act cell-autonomously anti-apoptotic gene ced-9 al/rapaav death failing cell-death process requires al/rapaav death requires al/rapaav cell continued endogenous cell-death genes genes function cell-autonomously pro-apoptotic genes ced-3 pro-apoptotic genes egl-1 regulate cell death engulfment-defective double mutant phagocyte-dependent cell deaths cell-death suicide genes al/rapaav exhibited morphological cell-killing activity independent cell-death suicide pathway al/rapaav cell membranes al/rapaav cell death al/rapaav death occurs cell-killing activities independent elegans search search caspase-mediated suicide pathway privacy choices/manage cookies al/rapaav death process caenorhabditis elegans male cell-death genes egl-1 anti-cd47 antibodies programmed cell death larval stage animals al/rapaav cell corpse al/rapaav homolog survives engulfment-mediated cell deaths purified digestion products independent apoptotic pathways al/rapaav cytoplasmic refractility al/rapaav cell fated creative commons license wild-type male developing male tail

Questions {❓}

Are there other assisted suicides?
Do assisted suicides exist in other species?
How might engulfment promote the death process?
Al/rapaav require assistance by an engulfing cell to die?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans
         description:Programmed cell deaths in the nematode Caenorhabditis elegans are generally considered suicides. Dying cells are engulfed by neighboring cells in a process of phagocytosis. To better understand the interaction between the engulfment and death processes, we analyzed B.al/rapaav cell death, which has been previously described as engulfment-dependent and hence as a possible murder. We found that B.al/rapaav is resistant to caspase-pathway activation: the caspase-mediated suicide pathway initiates the cell-death process but is insufficient to cause B.al/rapaav death without the subsequent assistance of engulfment. When the engulfing cell P12.pa is absent, other typically non-phagocytic cells can display cryptic engulfment potential and facilitate this death. We term this death an “assisted suicide” and propose that assisted suicides likely occur in other organisms. The study of assisted suicides might provide insight into non-cell autonomous influences on cell death. Understanding the mechanism that causes B.al/rapaav to be resistant to activation of the caspase pathway might reveal the basis of differences in the sensitivity to apoptotic stimuli of tumor and normal cells, a key issue in the field of cancer therapeutics.
         datePublished:2016-05-16T00:00:00Z
         dateModified:2016-05-16T00:00:00Z
         pageStart:1
         pageEnd:14
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s12915-016-0262-5
         keywords:
            Programmed cell death
            Apoptosis
            Phagocytosis
            Engulfment
            Phagoptosis
             C. elegans
            Life Sciences
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig6_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig7_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig8_HTML.gif
         isPartOf:
            name:BMC Biology
            issn:
               1741-7007
            volumeNumber:14
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Holly L. Johnsen
               affiliation:
                     name:Massachusetts Institute of Technology
                     address:
                        name:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:H. Robert Horvitz
               affiliation:
                     name:Massachusetts Institute of Technology
                     address:
                        name:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans
      description:Programmed cell deaths in the nematode Caenorhabditis elegans are generally considered suicides. Dying cells are engulfed by neighboring cells in a process of phagocytosis. To better understand the interaction between the engulfment and death processes, we analyzed B.al/rapaav cell death, which has been previously described as engulfment-dependent and hence as a possible murder. We found that B.al/rapaav is resistant to caspase-pathway activation: the caspase-mediated suicide pathway initiates the cell-death process but is insufficient to cause B.al/rapaav death without the subsequent assistance of engulfment. When the engulfing cell P12.pa is absent, other typically non-phagocytic cells can display cryptic engulfment potential and facilitate this death. We term this death an “assisted suicide” and propose that assisted suicides likely occur in other organisms. The study of assisted suicides might provide insight into non-cell autonomous influences on cell death. Understanding the mechanism that causes B.al/rapaav to be resistant to activation of the caspase pathway might reveal the basis of differences in the sensitivity to apoptotic stimuli of tumor and normal cells, a key issue in the field of cancer therapeutics.
      datePublished:2016-05-16T00:00:00Z
      dateModified:2016-05-16T00:00:00Z
      pageStart:1
      pageEnd:14
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12915-016-0262-5
      keywords:
         Programmed cell death
         Apoptosis
         Phagocytosis
         Engulfment
         Phagoptosis
          C. elegans
         Life Sciences
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig6_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig7_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12915-016-0262-5/MediaObjects/12915_2016_262_Fig8_HTML.gif
      isPartOf:
         name:BMC Biology
         issn:
            1741-7007
         volumeNumber:14
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Holly L. Johnsen
            affiliation:
                  name:Massachusetts Institute of Technology
                  address:
                     name:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:H. Robert Horvitz
            affiliation:
                  name:Massachusetts Institute of Technology
                  address:
                     name:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:BMC Biology
      issn:
         1741-7007
      volumeNumber:14
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Massachusetts Institute of Technology
      address:
         name:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Massachusetts Institute of Technology
      address:
         name:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Holly L. Johnsen
      affiliation:
            name:Massachusetts Institute of Technology
            address:
               name:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:H. Robert Horvitz
      affiliation:
            name:Massachusetts Institute of Technology
            address:
               name:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
      name:Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA

External Links {🔗}(148)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js
Video.js

CDN Services {📦}

Crossref
Net/play">

LINK . SPRINGER . COM {}