We are analyzing https://link.springer.com/article/10.1186/ar3736.

Title:
Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis | Arthritis Research & Therapy
Description:
Introduction Interleukin-10 (IL-10) producing B cells, also known as regulatory B (Breg) cells, play a key role in controlling autoimmunity. Our laboratory and others have demonstrated a pivotal role for Bregs in rheumatological disorders, including experimental models of arthritis and lupus. The aim of this study was to identify the role of endogenous IL-10 secreting B cells in vivo in controlling the induction and disease progression of collagen-induced arthritis (CIA). Methods We generated chimeric mice that had IL-10 knocked-out specifically in the B cell population. These mice were compared with wild-type (WT) B cell chimeric mice for their susceptibility to CIA. Results Here we report that chimeric mice specifically lacking IL-10 producing B cells (IL-10-/- B cell) developed an exacerbated CIA compared to chimeric wild type B cell (WT B cell) mice. A marked increase in inflammatory Th1 and Th17 cells were detected in IL-10-/-B cell mice compared to WT B cell mice. Furthermore, there was a reduction in IL-10 secreting CD4+ Tr1 cells in these animals. Conclusions IL-10 producing B cells restrain inflammation by promoting differentiation of immuno-regulatory over pro-inflammatory T cells and, hence, act to maintain tolerance.
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Keywords {🔍}

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Topics {✒️}

administered biotin-anti-ifnγ-labelled antibodies cytokine-biotin-anti-cytokine mab complexes produce anti-collagen antibodies article download pdf anti-mouse il-10 apc b-cell-derived il-10 specific pathogen-free conditions anti-cd4 fitc mab th1/th2 cytokine patterns potent pro-inflammatory cytokines antigen-induced experimental arthritis increased pro-inflammatory cytokines severe collagen-induced arthritis pro-inflammatory th1 cytokines antigen-mediated joint swelling 50 ng/ml sigma-aldrich 500 ng/ml sigma-aldrich full size image cd25+cd4+ tr cells rosser & claudia mauri type ii collagen il-10-reporter expressing regulatory article number r32 cytokine flowcytomix kit cell-dependent inflammatory responses protease-activated receptor 2 compared foxp3+treg numbers anti-foxp3 mab antigen induced arthritis antigen-induced arthritis immune-regulatory tr1 cells privacy choices/manage cookies draining lymph node systemic experimental arthritis pro-inflammatory cytokines springer semin immunopathol evans jg cytokine gene activation home office anti-cd3 antibody chimeric wild type cell-derived il-10 results bone marrow preparations bone marrow consisting host bone marrow intracellular cytokine staining increased intestinal-gas collagen-induced arthritis pro-inflammatory th1 anti-mbsa antibodies

Questions {❓}

Mauri C, Carter N: Is there a feudal hierarchy amongst regulatory immune cells?

Schema {🗺️}

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