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Title:
A short guide to long non-coding RNA gene nomenclature | Human Genomics
Description:
The HUGO Gene Nomenclature Committee (HGNC) is the only organisation authorised to assign standardised nomenclature to human genes. Of the 38,000 approved gene symbols in our database ( http://www.genenames.org ), the majority represent protein-coding (pc) genes; however, we also name pseudogenes, phenotypic loci, some genomic features, and to date have named more than 8,500 human non-protein coding RNA (ncRNA) genes and ncRNA pseudogenes. We have already established unique names for most of the small ncRNA genes by working with experts for each class. Small ncRNAs can be defined into their respective classes by their shared homology and common function. In contrast, long non-coding RNA (lncRNA) genes represent a disparate set of loci related only by their size, more than 200 bases in length, share no conserved sequence homology, and have variable functions. As with pc genes, wherever possible, lncRNAs are named based on the known function of their product; a short guide is presented herein to help authors when developing novel gene symbols for lncRNAs with characterised function. Researchers must contact the HGNC with their suggestions prior to publication, to check whether the proposed gene symbol can be approved. Although thousands of lncRNAs have been predicted in the human genome, for the vast majority their function remains unresolved. lncRNA genes with no known function are named based on their genomic context. Working with lncRNA researchers, the HGNC aims to provide unique and, wherever possible, meaningful gene symbols to all lncRNA genes.
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Keywords {๐}
gene, genes, lncrna, pubmed, hgnc, human, article, function, rna, nomenclature, noncoding, long, symbols, names, cas, google, scholar, approved, symbol, information, named, authors, genome, naming, central, wright, ncrna, rnas, antisense, figure, search, published, lncrnas, based, research, transcript, nature, privacy, cookies, guide, access, number, proteincoding, pseudogenes, loci, nonprotein, coding, unique, researchers, author,
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large-scale transcriptomic analyses article download pdf majority represent protein-coding privacy choices/manage cookies open access license pubmed returns dr ruth seal protein coding rna protein coding rna article wright lncrna research community authorsโ original file generate unnecessary confusion simple guidelines stated paramount nomenclature rule protein-coding gene noncoding rna gene ptenp1 regulates levels imprinted antisense rna european economic area main content log require individual assessment wright mw cell-cycle promoters coding rna tincr ๏ฟฝtissue differentiation-inducing progenitor differentiation requires somatic tissue differentiation gene dense regions protein-coding genes conditions privacy policy long-established convention long noncoding rnas nucleic acids res van de vijver epidermal tissue differentiation assign standardised nomenclature proposed gene symbol mouse gene hotair gene symbol beginning specific developmental stages accepting optional cookies hgnc decision tree short-form representations pten-targeting mirna [13] references povey igf2r locus overlaps proximal pc gene lncrna categories annotated conserved sequence homology
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mainEntity:
headline:A short guide to long non-coding RNA gene nomenclature
description:The HUGO Gene Nomenclature Committee (HGNC) is the only organisation authorised to assign standardised nomenclature to human genes. Of the 38,000 approved gene symbols in our database (
http://www.genenames.org
), the majority represent protein-coding (pc) genes; however, we also name pseudogenes, phenotypic loci, some genomic features, and to date have named more than 8,500 human non-protein coding RNA (ncRNA) genes and ncRNA pseudogenes. We have already established unique names for most of the small ncRNA genes by working with experts for each class. Small ncRNAs can be defined into their respective classes by their shared homology and common function. In contrast, long non-coding RNA (lncRNA) genes represent a disparate set of loci related only by their size, more than 200 bases in length, share no conserved sequence homology, and have variable functions. As with pc genes, wherever possible, lncRNAs are named based on the known function of their product; a short guide is presented herein to help authors when developing novel gene symbols for lncRNAs with characterised function. Researchers must contact the HGNC with their suggestions prior to publication, to check whether the proposed gene symbol can be approved. Although thousands of lncRNAs have been predicted in the human genome, for the vast majority their function remains unresolved. lncRNA genes with no known function are named based on their genomic context. Working with lncRNA researchers, the HGNC aims to provide unique and, wherever possible, meaningful gene symbols to all lncRNA genes.
datePublished:2014-04-09T00:00:00Z
dateModified:2014-04-09T00:00:00Z
pageStart:1
pageEnd:4
license:http://creativecommons.org/publicdomain/zero/1.0/
sameAs:https://doi.org/10.1186/1479-7364-8-7
keywords:
Long non-coding RNA
Nomenclature
ncRNA
lncRNA
Human Genetics
Proteomics
Bioinformatics
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ScholarlyArticle:
headline:A short guide to long non-coding RNA gene nomenclature
description:The HUGO Gene Nomenclature Committee (HGNC) is the only organisation authorised to assign standardised nomenclature to human genes. Of the 38,000 approved gene symbols in our database (
http://www.genenames.org
), the majority represent protein-coding (pc) genes; however, we also name pseudogenes, phenotypic loci, some genomic features, and to date have named more than 8,500 human non-protein coding RNA (ncRNA) genes and ncRNA pseudogenes. We have already established unique names for most of the small ncRNA genes by working with experts for each class. Small ncRNAs can be defined into their respective classes by their shared homology and common function. In contrast, long non-coding RNA (lncRNA) genes represent a disparate set of loci related only by their size, more than 200 bases in length, share no conserved sequence homology, and have variable functions. As with pc genes, wherever possible, lncRNAs are named based on the known function of their product; a short guide is presented herein to help authors when developing novel gene symbols for lncRNAs with characterised function. Researchers must contact the HGNC with their suggestions prior to publication, to check whether the proposed gene symbol can be approved. Although thousands of lncRNAs have been predicted in the human genome, for the vast majority their function remains unresolved. lncRNA genes with no known function are named based on their genomic context. Working with lncRNA researchers, the HGNC aims to provide unique and, wherever possible, meaningful gene symbols to all lncRNA genes.
datePublished:2014-04-09T00:00:00Z
dateModified:2014-04-09T00:00:00Z
pageStart:1
pageEnd:4
license:http://creativecommons.org/publicdomain/zero/1.0/
sameAs:https://doi.org/10.1186/1479-7364-8-7
keywords:
Long non-coding RNA
Nomenclature
ncRNA
lncRNA
Human Genetics
Proteomics
Bioinformatics
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https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1479-7364-8-7/MediaObjects/40246_2014_Article_63_Fig1_HTML.jpg
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- How much money does https://www.springernature.com/ make?
Analytics and Tracking {๐}
- Google Tag Manager
Libraries {๐}
- Clipboard.js
- Prism.js
CDN Services {๐ฆ}
- Crossref