We are analyzing https://link.springer.com/article/10.1186/1479-7364-6-9.

Title:
CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults | Human Genomics
Description:
Objective Leukocyte count has been associated with blood pressure, hypertension, and hypertensive complications. We hypothesized that polymorphisms in the CXCL5 gene, which encodes the neutrophilic chemokine ENA-78, are associated with blood pressure in cardiovascular disease (CVD)-free adults and that these polymorphisms are functional. Methods and results A total of 192 community-dwelling participants without CVD or risk equivalents were enrolled. Two CXCL5 polymorphisms (−156 G > C (rs352046) and 398 G > A (rs425535)) were tested for associations with blood pressure. Allele-specific mRNA expression in leukocytes was also measured to determine whether heterozygosity was associated with allelic expression imbalance. In −156 C variant carriers, systolic blood pressure (SBP) was 7 mmHg higher than in −156 G/G wild-type homozygotes (131 ± 17 vs. 124 ± 14 mmHg; P = 0.008). Similarly, diastolic blood pressure (DBP) was 4 mmHg higher in −156 C variant carriers (78 ± 11 vs. 74 ± 11 mmHg; P = 0.013). In multivariate analysis of SBP, age, sex, body mass index, and the −156 G > C polymorphism were identified as significant variables. Age, sex, and the −156 G > C SNP were further associated with DBP, along with white blood cells. Allelic expression imbalance and significantly higher circulating ENA-78 concentrations were noted for variant carriers. Conclusion CXCL5 gene polymorphisms are functional and associated with variable blood pressure in CVD-free individuals. The role of CXCL5 as a hypertension- and CVD-susceptibility gene should be further explored.
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Keywords {🔍}

blood, article, pubmed, google, scholar, pressure, cxcl, cas, ena, hypertension, variant, sbp, polymorphisms, count, individuals, allele, study, genotype, expression, mmhg, wbc, mrna, protein, cardiovascular, gene, higher, dbp, concentrations, usa, carriers, association, analysis, risk, significant, snp, analyses, hypertens, data, age, sex, white, inflammation, cell, chemokine, cells, genetic, crp, diabetes, promoter, research,

Topics {✒️}

bronchioloalveolar carcinoma-derived c-x full size image cardiovascular disease-free adults allele-specific mrna quantification allele-specific mrna expression final hypothesis-generating evidence allele-specific transcript quantification adipose-tissue derived factor oxidized low-density lipoprotein taking anti-hypertensive medications e-selectin allelic expression imbalance full access tumor necrosis factor-alpha prototypical pro-inflammatory markers epithelial neutrophil-activating peptide established cardiovascular disease article download pdf genotype interaction term c-reactive protein concentration coronary heart disease step-type selection methods circulating high-sensitivity crp human endothelial cells neutrophil-activating peptide ena-78 primary antiphospholipid syndrome preexisting sample size anti-inflammatory agents peripheral vascular disease significant sex-specific effect privacy choices/manage cookies plasma chemokine levels congestive heart failure coronary artery disease normal cholesterol levels biochem cell biol cardiovascular disease cvd-free individuals inflammatory-hypertensive relationship results consistently higher expression threefold higher expression c-reactive protein authors’ original file cardiovascular adverse events endothelial progenitor cells high blood cholesterol rneasy mini kit clinical cohorts showing abdominal aortic aneurysm 4-fold higher expression

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Horne BD, Anderson JL, John JM, Weaver A, Bair TL, Jensen KR, Renlund DG, Muhlestein JB, Intermountain Heart Collaborative Study Group: Which white blood cell subtypes predict increased cardiovascular risk?
Milionis HJ, Liberopoulos EN, Achimastos A, Elisaf MS, Mikhailidis DP: Statins: another class of antihypertensive agents?

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         headline:CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults
         description:Leukocyte count has been associated with blood pressure, hypertension, and hypertensive complications. We hypothesized that polymorphisms in the CXCL5 gene, which encodes the neutrophilic chemokine ENA-78, are associated with blood pressure in cardiovascular disease (CVD)-free adults and that these polymorphisms are functional. A total of 192 community-dwelling participants without CVD or risk equivalents were enrolled. Two CXCL5 polymorphisms (−156 G > C (rs352046) and 398 G > A (rs425535)) were tested for associations with blood pressure. Allele-specific mRNA expression in leukocytes was also measured to determine whether heterozygosity was associated with allelic expression imbalance. In −156 C variant carriers, systolic blood pressure (SBP) was 7 mmHg higher than in −156 G/G wild-type homozygotes (131 ± 17 vs. 124 ± 14 mmHg; P = 0.008). Similarly, diastolic blood pressure (DBP) was 4 mmHg higher in −156 C variant carriers (78 ± 11 vs. 74 ± 11 mmHg; P = 0.013). In multivariate analysis of SBP, age, sex, body mass index, and the −156 G > C polymorphism were identified as significant variables. Age, sex, and the −156 G > C SNP were further associated with DBP, along with white blood cells. Allelic expression imbalance and significantly higher circulating ENA-78 concentrations were noted for variant carriers. CXCL5 gene polymorphisms are functional and associated with variable blood pressure in CVD-free individuals. The role of CXCL5 as a hypertension- and CVD-susceptibility gene should be further explored.
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            Leukocytes
            Human Genetics
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      headline:CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults
      description:Leukocyte count has been associated with blood pressure, hypertension, and hypertensive complications. We hypothesized that polymorphisms in the CXCL5 gene, which encodes the neutrophilic chemokine ENA-78, are associated with blood pressure in cardiovascular disease (CVD)-free adults and that these polymorphisms are functional. A total of 192 community-dwelling participants without CVD or risk equivalents were enrolled. Two CXCL5 polymorphisms (−156 G > C (rs352046) and 398 G > A (rs425535)) were tested for associations with blood pressure. Allele-specific mRNA expression in leukocytes was also measured to determine whether heterozygosity was associated with allelic expression imbalance. In −156 C variant carriers, systolic blood pressure (SBP) was 7 mmHg higher than in −156 G/G wild-type homozygotes (131 ± 17 vs. 124 ± 14 mmHg; P = 0.008). Similarly, diastolic blood pressure (DBP) was 4 mmHg higher in −156 C variant carriers (78 ± 11 vs. 74 ± 11 mmHg; P = 0.013). In multivariate analysis of SBP, age, sex, body mass index, and the −156 G > C polymorphism were identified as significant variables. Age, sex, and the −156 G > C SNP were further associated with DBP, along with white blood cells. Allelic expression imbalance and significantly higher circulating ENA-78 concentrations were noted for variant carriers. CXCL5 gene polymorphisms are functional and associated with variable blood pressure in CVD-free individuals. The role of CXCL5 as a hypertension- and CVD-susceptibility gene should be further explored.
      datePublished:2012-08-02T00:00:00Z
      dateModified:2012-08-02T00:00:00Z
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         ENA-78
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         Hypertension
         Leukocytes
         Human Genetics
         Proteomics
         Bioinformatics
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      name:Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, USA
      name:Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, USA
      name:Division of Cardiovascular Medicine and Department of Veterans Affairs Medical Center, University of Florida College of Medicine, Gainesville, USA
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