We are analyzing https://link.springer.com/article/10.1186/1475-4924-2-7.

Title:
Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression | Journal of Biology
Description:
Background It is widely believed that cell-size checkpoints help to coordinate cell growth and cell-cycle progression, so that proliferating eukaryotic cells maintain their size. There is strong evidence for such size checkpoints in yeasts, which maintain a constant cell-size distribution as they proliferate, even though large yeast cells grow faster than small yeast cells. Moreover, when yeast cells are shifted to better or worse nutrient conditions, they alter their size threshold within one cell cycle. Populations of mammalian cells can also maintain a constant size distribution as they proliferate, but it is not known whether this depends on cell-size checkpoints. Results We show that proliferating rat Schwann cells do not require a cell-size checkpoint to maintain a constant cell-size distribution, as, unlike yeasts, large and small Schwann cells grow at the same rate, which depends on the concentration of extracellular growth factors. In addition, when shifted from serum-free to serum-containing medium, Schwann cells take many divisions to increase their size to that appropriate to the new condition, suggesting that they do not have cell-size checkpoints similar to those in yeasts. Conclusions Proliferating Schwann cells and yeast cells seem to use different mechanisms to coordinate their growth with cell-cycle progression. Whereas yeast cells use cell-size checkpoints, Schwann cells apparently do not. It seems likely that many mammalian cells resemble Schwann cells in this respect.
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Keywords {🔍}

cells, cell, size, schwann, growth, medium, protein, cellsize, checkpoints, rate, article, yeast, figure, proliferating, cycle, google, scholar, grow, time, pubmed, cellcycle, cas, progression, maintain, division, volume, constant, small, culture, fcs, extracellular, measured, control, independent, aphidicolin, mammalian, faster, results, shown, synthesis, yeasts, counter, hours, amount, analysis, coordinate, large, conditions, similar, day,

Topics {✒️}

antigen-bearing antigen-presenting cells serum-free schwann-cell-conditioned medium short-lived proteins increase fibronectin-coated culture dishes schwann-cell-conditioned medium [2] fibronectin-coated culture dish blocking cell-cycle progression promote cell-cycle progression trophic factor-mediated coupling laminin-coated culture dishes coordinate cell-cycle progression aphidicolin-arrested schwann cells article download pdf cell-size checkpoint constant cell-size distribution yeast cell-size checkpoints require cell-size checkpoints growth-modulated size control average cell-cycle times yeast cell proliferation cell-size checkpoints ensure open access license privacy choices/manage cookies article conlon martin raff continues cell-size checkpoints similar edgar ba medical research council schwann cell growth cell-cycle progression animal cell proliferation yeast cell grows molecular cell biology university college london assess cell-cycle time research article related subjects bovine serum albumin yeast cell growth cell-cycle activators cell cycle arrests serum-free sf medium hypothetical daughter cells coordinate cell growth schwann cell size determine cell-growth rate stimulate cell growth cell division cycle 2 μg/ml aphidicolin total cell lysate

Questions {❓}

Do large and small Schwann cells synthesize proteins at the same rate?
How do fission yeast cells grow and connect growth to the mitotic cycle?
How is this achieved, and is the mechanism the same for all eukaryotic cells?
Why do yeasts and Schwann cells coordinate cell growth and cell-cycle progression so differently?

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