We are analyzing https://link.springer.com/article/10.1186/1471-2407-12-306.

Title:
The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients | BMC Cancer
Description:
Background Tumor associated macrophages (TAMs) are alternatively activated macrophages that enhance tumor progression by promoting tumor cell invasion, migration and angiogenesis. TAMs have an anti-inflammatory function resembling M2 macrophages. CD163 is regarded as a highly specific monocyte/macrophage marker for M2 macrophages. In this study we evaluated the specificity of using the M2 macrophage marker CD163 as a TAM marker and compared its prognostic value with the more frequently used pan-macrophage marker CD68. We also analyzed the prognostic value of the localization of CD163+ and CD68+ myeloid cells in human breast cancer. Methods The extent of infiltrating CD163+ or CD68+ myeloid cells in tumor nest versus tumor stroma was evaluated by immunohistochemistry in tissue microarrays with tumors from 144 breast cancer cases. Spearman’s Rho and χ2 tests were used to examine the correlations between CD163+ or CD68+ myeloid cells and clinicopathological parameters. Kaplan Meier analysis and Cox proportional hazards modeling were used to assess the impact of CD163+ and CD68+ myeloid cells in tumor stroma and tumor nest, respectively, on recurrence free survival, breast cancer specific and overall survival. Results We found that infiltration of CD163+ and CD68+ macrophages into tumor stroma, but not into tumor nest, were of clinical relevance. CD163+ macrophages in tumor stroma positively correlated with higher grade, larger tumor size, Ki67 positivity, estrogen receptor negativity, progesterone receptor negativity, triple-negative/basal-like breast cancer and inversely correlated with luminal A breast cancer. Some CD163+ areas lacked CD68 expression, suggesting that CD163 could be used as a general anti-inflammatory myeloid marker with prognostic impact. CD68+ macrophages in tumor stroma positively correlated to tumor size and inversely correlated to luminal A breast cancer. More importantly, CD68 in tumor stroma was an independent prognostic factor for reduced breast cancer specific survival. Conclusion These findings highlight the importance of analyzing the localization rather than merely the presence of TAMs as a prognostic marker for breast cancer patients.
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Keywords {🔍}

cancer, breast, macrophages, cells, tumor, infiltration, pubmed, article, expression, google, scholar, patients, correlated, marker, tams, cas, prognostic, dense, luminal, figure, macrophage, survival, triplenegativebasallike, data, gene, table, analysis, stroma, size, receptor, density, myeloid, human, rfs, bcss, authors, presence, specific, outcome, correlation, patient, primary, file, clinical, subtypes, features, full, cell, antiinflammatory, localization,

Topics {✒️}

pre-publication history anti-granulin antibody hpa028747 specific monocyte/macrophage marker envisionflex high ph-kit anti-inflammatory m2 macrophages article download pdf full size image systemic t-cell response paraffin-embedded tissue samples triple-negative breast cancer pan-macrophage marker cd68 anti-inflammatory cd163 marker pan-macrophage marker frequently related subjects larger triple-negative/basal pro-inflammatory m1 macrophages microarray profile sets expression profiles--database full access medical research council umas research foundations gene expression levels privacy choices/manage cookies human breast cancer distinct immune functions cd208/dc-lamp staining absent/sparse macrophage infiltration cell rich areas author information authors human dendritic cells gene expression analysis anti-inflammatory environment [4] independent risk factor breast cancer specific anti-cancer therapy alternatively activated macrophages promoting tumor invasion monocyte/macrophage lineage anti-inflammatory subtypes specific phenotypic markers tumour-stroma ratio human colorectal cancer multivariate analyses revealed tumor-promoting capabilities monocyte/macrophage morphology including breast cancer gene expression data primary breast cancer mature m2 macrophages flow cytometric analyses

Schema {🗺️}

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         description:Tumor associated macrophages (TAMs) are alternatively activated macrophages that enhance tumor progression by promoting tumor cell invasion, migration and angiogenesis. TAMs have an anti-inflammatory function resembling M2 macrophages. CD163 is regarded as a highly specific monocyte/macrophage marker for M2 macrophages. In this study we evaluated the specificity of using the M2 macrophage marker CD163 as a TAM marker and compared its prognostic value with the more frequently used pan-macrophage marker CD68. We also analyzed the prognostic value of the localization of CD163+ and CD68+ myeloid cells in human breast cancer. The extent of infiltrating CD163+ or CD68+ myeloid cells in tumor nest versus tumor stroma was evaluated by immunohistochemistry in tissue microarrays with tumors from 144 breast cancer cases. Spearman’s Rho and χ2 tests were used to examine the correlations between CD163+ or CD68+ myeloid cells and clinicopathological parameters. Kaplan Meier analysis and Cox proportional hazards modeling were used to assess the impact of CD163+ and CD68+ myeloid cells in tumor stroma and tumor nest, respectively, on recurrence free survival, breast cancer specific and overall survival. We found that infiltration of CD163+ and CD68+ macrophages into tumor stroma, but not into tumor nest, were of clinical relevance. CD163+ macrophages in tumor stroma positively correlated with higher grade, larger tumor size, Ki67 positivity, estrogen receptor negativity, progesterone receptor negativity, triple-negative/basal-like breast cancer and inversely correlated with luminal A breast cancer. Some CD163+ areas lacked CD68 expression, suggesting that CD163 could be used as a general anti-inflammatory myeloid marker with prognostic impact. CD68+ macrophages in tumor stroma positively correlated to tumor size and inversely correlated to luminal A breast cancer. More importantly, CD68 in tumor stroma was an independent prognostic factor for reduced breast cancer specific survival. These findings highlight the importance of analyzing the localization rather than merely the presence of TAMs as a prognostic marker for breast cancer patients.
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         Medicine/Public Health
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