We are analyzing https://link.springer.com/article/10.1007/s44307-025-00057-9.

Title:
Pathogenesis of influenza and SARS-CoV-2 co-infection at the extremes of age: decipher the ominous tales of immune vulnerability | Advanced Biotechnology
Description:
The co-circulation of influenza and SARS-CoV-2 has led to co-infection events, primarily affecting children and older adults, who are at higher risk for severe disease. Although co-infection prevalence is relatively low, it is associated with worse outcomes compared to mono-infections. Previous studies have shown that the outcomes of co-infection depend on multiple factors, including viral interference, virus-host interaction and host response. Children and the elderly exhibit distinct patterns of antiviral response, which involve airway epithelium, mucociliary clearance, innate and adaptive immune cells, and inflammatory mediators. This review explores the pathogeneses of SARS-CoV-2 and influenza co-infection, focusing on the antiviral responses in children and the elderly. By comparing immature immunity in children and immune senescence in older adults, we aim to provide insights for the clinical management of severe co-infection cases.
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Keywords {🔍}

pubmed, influenza, article, google, scholar, sarscov, cas, cells, coinfection, virus, central, viral, children, respiratory, adults, cell, immune, response, responses, infection, viruses, covid, older, immunity, severe, elderly, wang, human, disease, innate, lung, infections, mucus, severity, immunol, epithelium, replication, httpsdoiorgs, age, host, antiviral, airway, patients, clearance, compared, higher, outcomes, levels, coinfections, zhang,

Topics {✒️}

zi-feng yang reduced ifn-α/β production article download pdf hla-class ii antigens angiotensin-converting enzyme ii innate-adaptive immune crosstalk influenza a-sars-cov-2 coinfection releasing pro-inflammatory cytokines anti-inflammatory cytokines reflects virus-induced cell death virus-induced inflammatory mediators multi-organ failure due adopt pro-inflammatory phenotypes ifn-incompetent cells highlights t-cell functions diverging age-related immune suppression age-related immunological features potent antigen-presenting cells senescent antigen-presenting cells reduced ifn-γ levels control sars-cov-2 transmission sars-cov-2 generally experienced aging-related epithelial damages high-molecular weight glycoproteins recombinant human g-csf post-infection respiratory symptoms t-cell activation mediators cleaves sialic acids functional virus-specific circulating kill virus-infected cells reactive oxygen species inhibits sars-cov-2 infectivity quiñones-parra del valle obtain permission directly anti-influenza drug oseltamivir diminished virus-specific cd4+ reaching adult-level function anti-influenza combined therapy national inpatient sample privacy choices/manage cookies article mai weak cross-reactive cd8 + spike glycoprotein romero starke bmc infect dis intact influenza-specific cd4+ immature cough reflex sars-cov-2 mono-infection influenza virus-infected mice

Questions {❓}

Co-circulation, Co-infection of SARS-CoV-2 and influenza virus, where will it go?
Is the developmentally immature immune response in paediatric sepsis a recapitulation of immune tolerance?
Is viral coinfection a risk factor for severe lower respiratory tract infection?

Schema {🗺️}

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         description:The co-circulation of influenza and SARS-CoV-2 has led to co-infection events, primarily affecting children and older adults, who are at higher risk for severe disease. Although co-infection prevalence is relatively low, it is associated with worse outcomes compared to mono-infections. Previous studies have shown that the outcomes of co-infection depend on multiple factors, including viral interference, virus-host interaction and host response. Children and the elderly exhibit distinct patterns of antiviral response, which involve airway epithelium, mucociliary clearance, innate and adaptive immune cells, and inflammatory mediators. This review explores the pathogeneses of SARS-CoV-2 and influenza co-infection, focusing on the antiviral responses in children and the elderly. By comparing immature immunity in children and immune senescence in older adults, we aim to provide insights for the clinical management of severe co-infection cases.
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         SARS-CoV-2
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         Immunosenescence
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         Bioinformatics
         Genetics and Genomics
         Nucleic Acid Chemistry
         Cell Biology
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