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Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
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We are analyzing https://link.springer.com/article/10.1007/s43440-021-00303-6.

Title:
Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention | Pharmacological Reports
Description:
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?


Link.springer.com employs APACHE LENYA.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

ace, pubmed, sarscov, article, google, scholar, covid, cas, central, angiotensin, receptor, cells, receptors, coronavirus, role, disease, infection, viral, patients, human, virus, cell, protein, enzyme, lung, pulmonary, expression, spike, angiotensinconverting, ali, httpsdoiorgs, pathogenesis, system, binding, acute, med, pathway, studies, hypertension, pandemic, entry, type, potential, therapeutic, treatment, host, respiratory, injury, clinical, ards,

Topics {✒️}

angiotensin-converting enzyme-related carboxypeptidase angiotensin-ii–nf-κb axis full size image ace-2/angiotensin1-7/mas receptor disequilibrium oliveira-dos-santos aj renin–angiotensin–aldosterone system pathway lipopolysaccharide-induced lung injury single-molecule force spectroscopy ace/angiotensin ii/at1 receptor improved hyper-inflammatory status extra-mural research project janus kinase/signal transducers sarscov2s-ace2 protein–protein interaction phospholipid multi-lamellar bodies ultimately stimulate mas-related tumor necrosis factor-alpha full-length human ace2 renin–angiotensin–aldosterone system renin-angiotensin-aldosterone system ace/ang-ii/at1r central nervous system tissue-related signaling pathways alveolar-capillary diffusion capacity clathrin-mediated endocytosis pathway caveolae-independent endocytic pathway sars-cov-2 prompted ali human cell-derived protease acute lung injury sars-cov-2 induced ards angiotensin-converting enzyme 2 angiotensin-converting enzyme revealed dose-dependent lessening direct-acting antiviral drugs tentative sars-cov-2 therapeutics protein–protein interactions disclose sars-cov-2 indicating sars-cov-2 spike protein continue ace inhibitors/arb sars-cov-2 infects cells turner aj quantitative structure-activity relationship sars-cov-2 infected individuals mas receptor pole sars-cov-2-infected patients individual genetic susceptibility/receptivity privacy choices/manage cookies sars-cov-2 infectious disease sars-cov-2 entry factors protein-coupled receptors [39 recent sars-cov-2 pandemic

Questions {❓}

  • COVID-19 and individual genetic susceptibility/receptivity: Role of ACE1/ACE2 genes, immunity, inflammation and coagulation might the double x-chromosome in females be protective against SARS-COV-2 compared to the single x-chromosome in males?
  • COVID-19—does this disease kill due to imbalance of the renin angiotensin system (RAS) caused by genetic and gender differences in the response to viral ACE 2 attack?
  • Coronavirus: why men are more vulnerable to COVID-19 than women?
  • Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)?
  • Is application of ACE-2 inhibitors or AT1 blockers in COVID-19 patients with hypertension effective?
  • Whether anti-RAS drugs (ACEIs and ARBs) intensify the threat of SARS-CoV-2 infection?
  • While we wait for a vaccine against SARS-CoV-2, why not think about available drugs?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention
         description:Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis.
         datePublished:2021-06-27T00:00:00Z
         dateModified:2021-06-27T00:00:00Z
         pageStart:1539
         pageEnd:1550
         sameAs:https://doi.org/10.1007/s43440-021-00303-6
         keywords:
            Acute lung injury
            Acute respiratory distress syndrome
            Angiotensin-converting enzyme-2
            COVID-19
            SARS-CoV-2
            rhACE2
            Pharmacy
            Drug Safety and Pharmacovigilance
            Pharmacotherapy
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                        name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
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                        name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
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                        name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
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                     address:
                        name:Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia
                        type:PostalAddress
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                     name:Department of Pharmaceutics, School of Pharmaceutical Education and Research
                     address:
                        name:Department of Pharmaceutics, School of Pharmaceutical Education and Research, New Delhi, India
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                     name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
                     address:
                        name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
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ScholarlyArticle:
      headline:Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention
      description:Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis.
      datePublished:2021-06-27T00:00:00Z
      dateModified:2021-06-27T00:00:00Z
      pageStart:1539
      pageEnd:1550
      sameAs:https://doi.org/10.1007/s43440-021-00303-6
      keywords:
         Acute lung injury
         Acute respiratory distress syndrome
         Angiotensin-converting enzyme-2
         COVID-19
         SARS-CoV-2
         rhACE2
         Pharmacy
         Drug Safety and Pharmacovigilance
         Pharmacotherapy
      image:
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs43440-021-00303-6/MediaObjects/43440_2021_303_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs43440-021-00303-6/MediaObjects/43440_2021_303_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs43440-021-00303-6/MediaObjects/43440_2021_303_Fig4_HTML.png
      isPartOf:
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            2299-5684
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         name:Springer International Publishing
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            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      author:
            name:Ekta Shirbhate
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                  name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
                  address:
                     name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jaiprakash Pandey
            affiliation:
                  name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
                  address:
                     name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
                     type:PostalAddress
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                  name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
                  address:
                     name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
                     type:PostalAddress
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            name:Mehnaz Kamal
            affiliation:
                  name:Prince Sattam Bin Abdulaziz University
                  address:
                     name:Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia
                     type:PostalAddress
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            type:Person
            name:Talha Jawaid
            affiliation:
                  name:Al Imam Bin Saud Islamic University
                  address:
                     name:Department of Pharmacology, College of Medicine, Al Imam Bin Saud Islamic University, Riyadh, Kingdom of Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bapi Gorain
            affiliation:
                  name:Taylor’s University
                  address:
                     name:School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
                     type:PostalAddress
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            url:http://orcid.org/0000-0002-0890-769X
            affiliation:
                  name:Department of Pharmaceutics, School of Pharmaceutical Education and Research
                  address:
                     name:Department of Pharmaceutics, School of Pharmaceutical Education and Research, New Delhi, India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Harish Rajak
            affiliation:
                  name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
                  address:
                     name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
                     type:PostalAddress
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      name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
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      name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
      address:
         name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
         type:PostalAddress
      name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
      address:
         name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
         type:PostalAddress
      name:Prince Sattam Bin Abdulaziz University
      address:
         name:Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia
         type:PostalAddress
      name:Al Imam Bin Saud Islamic University
      address:
         name:Department of Pharmacology, College of Medicine, Al Imam Bin Saud Islamic University, Riyadh, Kingdom of Saudi Arabia
         type:PostalAddress
      name:Taylor’s University
      address:
         name:School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
         type:PostalAddress
      name:Department of Pharmaceutics, School of Pharmaceutical Education and Research
      address:
         name:Department of Pharmaceutics, School of Pharmaceutical Education and Research, New Delhi, India
         type:PostalAddress
      name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
      address:
         name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ekta Shirbhate
      affiliation:
            name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
            address:
               name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
               type:PostalAddress
            type:Organization
      name:Jaiprakash Pandey
      affiliation:
            name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
            address:
               name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
               type:PostalAddress
            type:Organization
      name:Vijay K. Patel
      affiliation:
            name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
            address:
               name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
               type:PostalAddress
            type:Organization
      name:Mehnaz Kamal
      affiliation:
            name:Prince Sattam Bin Abdulaziz University
            address:
               name:Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Talha Jawaid
      affiliation:
            name:Al Imam Bin Saud Islamic University
            address:
               name:Department of Pharmacology, College of Medicine, Al Imam Bin Saud Islamic University, Riyadh, Kingdom of Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Bapi Gorain
      affiliation:
            name:Taylor’s University
            address:
               name:School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
               type:PostalAddress
            type:Organization
      name:Prashant Kesharwani
      url:http://orcid.org/0000-0002-0890-769X
      affiliation:
            name:Department of Pharmaceutics, School of Pharmaceutical Education and Research
            address:
               name:Department of Pharmaceutics, School of Pharmaceutical Education and Research, New Delhi, India
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Harish Rajak
      affiliation:
            name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University)
            address:
               name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
      name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
      name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India
      name:Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia
      name:Department of Pharmacology, College of Medicine, Al Imam Bin Saud Islamic University, Riyadh, Kingdom of Saudi Arabia
      name:School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
      name:Department of Pharmaceutics, School of Pharmaceutical Education and Research, New Delhi, India
      name:Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, India

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