We are analyzing https://link.springer.com/article/10.1007/s40778-018-0141-9.

Title:
Peripheral Blood Stem Cell Mobilization: a Look Ahead | Current Stem Cell Reports
Description:
Purpose of Review Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to recapitulate lifelong hematopoiesis, but in some patients and normal donors, reaching critical threshold stem cell numbers is difficult to achieve. Novel strategies, particularly those offering rapid mobilization and reduced costs, remain an area of interest. This review summarizes critical scientific underpinnings in understanding the process of stem cell mobilization, with a focus on new or improved strategies for their efficient collection and engraftment. Recent Findings Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress identify strategies to collect more potent competing HSC, and new methods to optimize stem cell collection and engraftment are being evaluated. Summary Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.
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Keywords {🔍}

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Topics {✒️}

cxcr4 antagonist 4f-benzoyl-tn14003 autologous stem-cell mobilization granulocyte-colony-stimulating factor granulocyte colony-stimulating factor long-term engraftment capability g-csf versus placebo hematopoietic stem/progenitor cells month download article/chapter cd26-mediated neutrotransmitter neuropeptide augment cytokine-induced mobilization steroidal anti-inflammatory drugs understand true physiology/pathology hematopoietic cell transplantation g-csf induced mobilization mobilizes hematopoietic stem stem cell biology sympathetic nerve-macrophage interplay stem cell mobilization cxcr4/cxcl12 chemotactic interaction stem cell heterogeneity relapsed/refractory breast cancer hematopoietic stem cells human hematopoietic stem mobilize stem cells stem cell rev nf-κb signaling pathway sphingosine-1-phosphate facilitates trafficking g-csf/amd3100 mobilization bone marrow transplant excellent anti-hiv activity peripheral blood mobilization mouse bone marrow mobilized stem cells cord blood cells cd34+ hematopoietic cells stem cells dev human cord blood progenitor cell mobilization nucleotide sugar udp-glucose c5-deficient mice supports peripheral blood increases human cd34+ cells superior repopulating ability current collection approaches bone marrow neutrophils potently inhibit chemotaxis osteolineage cell apoptosis hematopoietic progenitor cells peripheral sympathetic nerves

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         description:Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to recapitulate lifelong hematopoiesis, but in some patients and normal donors, reaching critical threshold stem cell numbers is difficult to achieve. Novel strategies, particularly those offering rapid mobilization and reduced costs, remain an area of interest. This review summarizes critical scientific underpinnings in understanding the process of stem cell mobilization, with a focus on new or improved strategies for their efficient collection and engraftment. Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress identify strategies to collect more potent competing HSC, and new methods to optimize stem cell collection and engraftment are being evaluated. Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.
         datePublished:2018-10-23T00:00:00Z
         dateModified:2018-10-23T00:00:00Z
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         pageEnd:281
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            Peripheral blood stem cell mobilization
            Hematopoietic stem cells
            Stem cell collection
            HSC egress
            High-engrafting stem cells
            Hypoxic collection
            Cell Biology
            Stem Cells
            Biomedicine
            general
            Gene Therapy
            Biomedical Engineering/Biotechnology
            Immunology
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      headline:Peripheral Blood Stem Cell Mobilization: a Look Ahead
      description:Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to recapitulate lifelong hematopoiesis, but in some patients and normal donors, reaching critical threshold stem cell numbers is difficult to achieve. Novel strategies, particularly those offering rapid mobilization and reduced costs, remain an area of interest. This review summarizes critical scientific underpinnings in understanding the process of stem cell mobilization, with a focus on new or improved strategies for their efficient collection and engraftment. Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress identify strategies to collect more potent competing HSC, and new methods to optimize stem cell collection and engraftment are being evaluated. Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.
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      dateModified:2018-10-23T00:00:00Z
      pageStart:273
      pageEnd:281
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         Peripheral blood stem cell mobilization
         Hematopoietic stem cells
         Stem cell collection
         HSC egress
         High-engrafting stem cells
         Hypoxic collection
         Cell Biology
         Stem Cells
         Biomedicine
         general
         Gene Therapy
         Biomedical Engineering/Biotechnology
         Immunology
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