We are analyzing https://link.springer.com/article/10.1007/s40495-017-0106-1.

Title:
Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention | Current Pharmacology Reports
Description:
Purpose of Review Rhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to nonspecifically enhance the natural resistance of the body to both physical and behavior stresses for fighting fatigue and depression. We summarize the information with respect to the new pharmacological activities of Rhodiola rosea extracts and its underlying molecular mechanisms in this review article. Recent Findings In addition to its multiplex stress-protective activity, Rhodiola rosea extracts have recently demonstrated its anti-aging, anti-inflammation, immunostimulating, DNA repair, and anti-cancer effects in different model systems. Molecular mechanisms of Rhodiola rosea extracts’ action have been studied mainly along with one of its bioactive compounds, salidroside. Both Rhodiola rosea extracts and salidroside have contrast molecular mechanisms on cancer and normal physiological functions. For cancer, Rhodiola rosea extracts and salidroside inhibit the mTOR pathway and reduce angiogenesis through downregulation of the expression of HIF-1α/HIF-2α. For normal physiological functions, Rhodiola rosea extracts and salidroside activate the mTOR pathway, stimulate paracrine function, and promote neovascularization by inhibiting PHD3 and stabilizing HIF-1α proteins in skeletal muscles. In contrast to many natural compounds, salidroside is water-soluble and highly bioavailable via oral administration and concentrated in urine by kidney excretion. Summary Rhodiola rosea extracts and salidroside can impose cellular and systemic benefits similar to the effect of positive lifestyle interventions to normal physiological functions and for anti-cancer. The unique pharmacological properties of Rhodiola rosea extracts or salidroside deserve further investigation for cancer chemoprevention, in particular for human urinary bladder cancer.
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Keywords {🔍}

rhodiola, rosea, salidroside, cancer, article, zhang, med, stress, wang, pubmed, google, scholar, extract, cell, liu, httpsdoiorgs, cells, chemoprevention, extracts, effects, pathway, res, httpsdoiorg, phytomedicine, human, effect, cas, chen, sci, shr, rep, growth, httpsdoiorgjphymed, rats, mtor, panossian, wikman, inhibition, resistance, expression, study, oxidative, content, antiaging, activity, model, plant, inhibits, chem, yao,

Topics {✒️}

org/content/dam/cancer-org/research/cancer-facts pi3k/akt/mtor pathway high-performance liquid chromatography bone marrow cells tandem mass spectrometry ha-ras transgenic model month download article/chapter figures/global-cancer-facts torsion-induced testicular injury hydrogen peroxide-induced injury statistics/global-cancer-facts bleomycin-induced pulmonary fibrosis muscle-secreted angiogenic factors environmental stress-induced death pu-bu-ci-ren increasing n-acetylglucosamine linkage hif-1α protein resulted tgf-β1/smad-2/-3 pathways suppressing nuclear factor-κb regulating gsk-3β phosphorylation ph-responsive nano-carrier nih award 1r01ca193967-01a1 castration-resistant prostate cancer hypoxia-induced death uvb-mediated oxidative damage cell-cell communications mediated multiplex stress-protective activity repeated low-dose regimen antioxid redox signal akt/mtor/p70s6k oxidative stress-induced apoptosis anti-aging agent kill stabilizing hif-1α proteins hif-1α/hif-2α disease subtype-independent biomarkers activating mtor signalling randomized placebo-controlled trial mapk signalling pathways placebo-controlled pilot study glucose-induced impairment white adipose tissues rhodiola crenulata induces figures-3rd-edition tumor-induced angiogenesis experimental clinical research tricarboxylic acid cycle privacy choices/manage cookies breast cancer chemoprevention human breast cancer salidroside induces apoptosis

Questions {❓}

Hypoxia inducible factor pathway and physiological adaptation: a cell survival pathway?
Rhodiola: an ordinary plant or a promising future therapy for pulmonary hypertension?
What is the evidence for stress resistance and slowed aging?
When anti-aging studies meet cancer chemoprevention: can anti-aging agent kill two birds with one blow?

Schema {🗺️}

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         headline:Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention
         description: Rhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to nonspecifically enhance the natural resistance of the body to both physical and behavior stresses for fighting fatigue and depression. We summarize the information with respect to the new pharmacological activities of Rhodiola rosea extracts and its underlying molecular mechanisms in this review article. In addition to its multiplex stress-protective activity, Rhodiola rosea extracts have recently demonstrated its anti-aging, anti-inflammation, immunostimulating, DNA repair, and anti-cancer effects in different model systems. Molecular mechanisms of Rhodiola rosea extracts’ action have been studied mainly along with one of its bioactive compounds, salidroside. Both Rhodiola rosea extracts and salidroside have contrast molecular mechanisms on cancer and normal physiological functions. For cancer, Rhodiola rosea extracts and salidroside inhibit the mTOR pathway and reduce angiogenesis through downregulation of the expression of HIF-1α/HIF-2α. For normal physiological functions, Rhodiola rosea extracts and salidroside activate the mTOR pathway, stimulate paracrine function, and promote neovascularization by inhibiting PHD3 and stabilizing HIF-1α proteins in skeletal muscles. In contrast to many natural compounds, salidroside is water-soluble and highly bioavailable via oral administration and concentrated in urine by kidney excretion. Rhodiola rosea extracts and salidroside can impose cellular and systemic benefits similar to the effect of positive lifestyle interventions to normal physiological functions and for anti-cancer. The unique pharmacological properties of Rhodiola rosea extracts or salidroside deserve further investigation for cancer chemoprevention, in particular for human urinary bladder cancer.
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      description: Rhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to nonspecifically enhance the natural resistance of the body to both physical and behavior stresses for fighting fatigue and depression. We summarize the information with respect to the new pharmacological activities of Rhodiola rosea extracts and its underlying molecular mechanisms in this review article. In addition to its multiplex stress-protective activity, Rhodiola rosea extracts have recently demonstrated its anti-aging, anti-inflammation, immunostimulating, DNA repair, and anti-cancer effects in different model systems. Molecular mechanisms of Rhodiola rosea extracts’ action have been studied mainly along with one of its bioactive compounds, salidroside. Both Rhodiola rosea extracts and salidroside have contrast molecular mechanisms on cancer and normal physiological functions. For cancer, Rhodiola rosea extracts and salidroside inhibit the mTOR pathway and reduce angiogenesis through downregulation of the expression of HIF-1α/HIF-2α. For normal physiological functions, Rhodiola rosea extracts and salidroside activate the mTOR pathway, stimulate paracrine function, and promote neovascularization by inhibiting PHD3 and stabilizing HIF-1α proteins in skeletal muscles. In contrast to many natural compounds, salidroside is water-soluble and highly bioavailable via oral administration and concentrated in urine by kidney excretion. Rhodiola rosea extracts and salidroside can impose cellular and systemic benefits similar to the effect of positive lifestyle interventions to normal physiological functions and for anti-cancer. The unique pharmacological properties of Rhodiola rosea extracts or salidroside deserve further investigation for cancer chemoprevention, in particular for human urinary bladder cancer.
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