We are analyzing https://link.springer.com/article/10.1007/s40291-016-0202-7.

Title:
Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases | Molecular Diagnosis & Therapy
Description:
Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcuma longa. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Are curcuminoids effective C-reactive protein-lowering agents in clinical practice?
Autophagic activation: a key piece of the puzzle for the curcumin-associated cognitive enhancement?
Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?

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