We are analyzing https://link.springer.com/article/10.1007/s40257-015-0142-8.

Title:
Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus: A Case–Control Study | American Journal of Clinical Dermatology
Description:
Previous reports have demonstrated an association between chronic inflammation with metabolic syndrome (MS) and cardiovascular risk factors. As lichen planus (LP) is a chronic inflammatory disease, the purpose of this study was to assess the prevalence of MS, dyslipidemia, insulin resistance and obesity in LP patients. A total of 79 patients with LP and 79 controls were examined in this case–control study. Both groups were evaluated for the presence of MS, dyslipidemia, obesity and insulin resistance, and other cardiovascular risk factors. Erythrocyte sedimentation rate, fibrinogen and C-reactive protein were measured as inflammation markers. The prevalence of MS was significantly higher in the patients with LP than in controls (26.6 vs. 12.7 %; P = 0.045). It was also significantly higher in LP patients with mucosal involvement than without (34.5 vs. 8.3 %; P = 0.032). Among the MS criteria, mean fasting blood glucose and diastolic blood pressure were also significantly higher in LP patients than in controls (P = 0.012 and P = 0.021, respectively). No significant differences between LP patients and controls were observed with respect to prevalence of dyslipidemia and insulin resistance (P = 0.866 and P = 1.000, respectively). However, duration of disease was significantly longer in patients with insulin resistance than in those without (P = 0.034). The patients with LP, particularly those with mucosal involvement, have a higher prevalence of MS, which is associated with a risk for cardiovascular diseases and diabetes mellitus.
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hospital-based case-control study month download article/chapter article american journal full article pdf privacy choices/manage cookies case–control study case-control study high blood cholesterol artvin state hospital insulin resistance study peripheral vascular diseases related subjects ece altun hüseyin yaman deniz aksu arıca chronic inflammatory disease coronary heart disease european economic area erythrocyte sedimentation rate c-reactive protein diastolic blood pressure curr rheumatol rep epidemiological findings relating gutiérrez-salmerón mt common pathogenic mechanisms oral lichen planus karadeniz technical university local ethics committee individual participants included cross-sectional study framingham risk score cardiovascular risk factors conditions privacy policy article baykal integrated treatment approach mucosal lichen planus fasting blood glucose lichenoid tissue reactions clinical dermatology aims journal finder publish accepting optional cookies dtsch dermatol ges metabolic syndrome check access dyslipidaemias endocrine system rodriguez-martines ma ethics declarations funding instant access clin endocrinol metab diabetes mellitus

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         description:Previous reports have demonstrated an association between chronic inflammation with metabolic syndrome (MS) and cardiovascular risk factors. As lichen planus (LP) is a chronic inflammatory disease, the purpose of this study was to assess the prevalence of MS, dyslipidemia, insulin resistance and obesity in LP patients. A total of 79 patients with LP and 79 controls were examined in this case–control study. Both groups were evaluated for the presence of MS, dyslipidemia, obesity and insulin resistance, and other cardiovascular risk factors. Erythrocyte sedimentation rate, fibrinogen and C-reactive protein were measured as inflammation markers. The prevalence of MS was significantly higher in the patients with LP than in controls (26.6 vs. 12.7 %; P = 0.045). It was also significantly higher in LP patients with mucosal involvement than without (34.5 vs. 8.3 %; P = 0.032). Among the MS criteria, mean fasting blood glucose and diastolic blood pressure were also significantly higher in LP patients than in controls (P = 0.012 and P = 0.021, respectively). No significant differences between LP patients and controls were observed with respect to prevalence of dyslipidemia and insulin resistance (P = 0.866 and P = 1.000, respectively). However, duration of disease was significantly longer in patients with insulin resistance than in those without (P = 0.034). The patients with LP, particularly those with mucosal involvement, have a higher prevalence of MS, which is associated with a risk for cardiovascular diseases and diabetes mellitus.
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      description:Previous reports have demonstrated an association between chronic inflammation with metabolic syndrome (MS) and cardiovascular risk factors. As lichen planus (LP) is a chronic inflammatory disease, the purpose of this study was to assess the prevalence of MS, dyslipidemia, insulin resistance and obesity in LP patients. A total of 79 patients with LP and 79 controls were examined in this case–control study. Both groups were evaluated for the presence of MS, dyslipidemia, obesity and insulin resistance, and other cardiovascular risk factors. Erythrocyte sedimentation rate, fibrinogen and C-reactive protein were measured as inflammation markers. The prevalence of MS was significantly higher in the patients with LP than in controls (26.6 vs. 12.7 %; P = 0.045). It was also significantly higher in LP patients with mucosal involvement than without (34.5 vs. 8.3 %; P = 0.032). Among the MS criteria, mean fasting blood glucose and diastolic blood pressure were also significantly higher in LP patients than in controls (P = 0.012 and P = 0.021, respectively). No significant differences between LP patients and controls were observed with respect to prevalence of dyslipidemia and insulin resistance (P = 0.866 and P = 1.000, respectively). However, duration of disease was significantly longer in patients with insulin resistance than in those without (P = 0.034). The patients with LP, particularly those with mucosal involvement, have a higher prevalence of MS, which is associated with a risk for cardiovascular diseases and diabetes mellitus.
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