We are analyzing https://link.springer.com/article/10.1007/s40005-019-00469-5.

Title:
Therapeutic targets and drugs for hyper-proliferation of vascular smooth muscle cells | Journal of Pharmaceutical Investigation
Description:
Background Vascular smooth muscle cells (VSMCs) play an important role in the biosynthetic, proliferative, and contractile functions of vessel walls. Hyper-proliferation of VSMCs is a crucial event associated with the pathogenesis of various vascular diseases including hypertension, atherosclerosis, and re-stenosis. Area covered A variety of studies have been performed to identify the signaling molecular targets or inhibitory drugs to suppress hyper-proliferation of VSMCs. Emerging studies have highlighted the relevance of targeting various signaling pathways, miRNAs, and post-translational modifications in controlling the hyper-proliferation of VSMCs. Expert opinion This review will introduce various inhibitors, a wide range of miRNAs, and different histone deacetylases related to the molecular targets and underlying signaling pathways involved in the regulation of VSMC hyper-proliferation. This will contribute to the development of promising approaches for the treatment of vascular diseases.
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Keywords {🔍}

pubmed, google, scholar, cas, smooth, muscle, vascular, cell, cells, proliferation, central, pulmonary, hypertension, targeting, article, res, microrna, physiol, circ, arterial, zhang, role, histone, med, signaling, human, liu, wang, hyperproliferation, heo, biol, mol, inhibits, artery, migration, research, atherosclerosis, sci, deacetylase, target, disease, nature, neointimal, formation, yang, privacy, cookies, content, journal, therapeutic,

Topics {✒️}

endothelial-cell-mediated vascular repair targeting mir-544a/pten axis hypoxia-induced pulmonary hypertension ampk-p53-p21 pathway month download article/chapter microrna-130a mediates proliferation endothelial cell-secreted microrna-126 antisense-mediated depletion reveal ros-mediated cell signaling akt/erk signaling pathway vascular smooth muscle lncrna lef1-as1 regulates nuclear beta-catenin translocation targeting cyclin-dependent kinases small molecule-mediated induction smooth muscle cells targeting bmpr2/smad1 signaling angiotensin ii-induced hypertension flores-le roux ja kyung-sun heo histone deacetylase inhibition coronary artery disease attenuate cell proliferation resveratrol attenuates hyperproliferation pulmonary arterial hypertension histone deacetylase implicated cultured vascular cells therapeutically targeted doca-induced hypertrophy acquired mitochondrial abnormalities signaling molecular targets histone deacetylases related compromise cell survival mir-23a regulates privacy choices/manage cookies flow-sensitive micrornas microrna expression signature pharmaceutical investigation aims full article pdf left heart disease including epigenetic inhibition suppress hyper-proliferation vsmc hyper-proliferation chungnam national university vascular diseases related subjects national research foundation histone deacetylase histone acetyltransferase complexes natriuretic peptide receptor

Questions {❓}

Do Vale GT, Tirapelli CR (2019) Are reactive oxygen species important mediators of vascular dysfunction?

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