We are analyzing https://link.springer.com/article/10.1007/s13577-021-00583-3.

Title:
FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells | Human Cell
Description:
Long noncoding RNA (lncRNA) FOXC2-AS1 has been reported to act as an oncogene in multiple human cancers. However, the clinical significance, functional role and underlying mechanism of FOXC2-AS1 in gastric cancer (GC) remains largely unknown. Here, we found that FOXC2-AS1 expression was significantly elevated in GC tissues and cells, and overexpression of FOXC2-AS1 indicated advanced TNM stage and shorter overall survival in GC patients. Functionally, knockdown of FOXC2-AS1 attenuated the proliferation, migration and invasion of GC cells, whereas overexpression of FOXC2-AS1 showed the opposite effects. Further investigation revealed that FOXC2-AS1 interacted with FOXC2 mRNA and repressed its degradation. FOXC2-AS1 recruited RNA methyltransferase NSUN2 to FOXC2 mRNA, increasing its m5C level and association with YBX1. Taken together, our findings suggested that FOXC2-AS1 acted as an oncogenic lncRNA by stabilizing FOXC2 mRNA in an m5C-dependent manner, which may provide a novel therapeutic target for GC.
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Keywords {🔍}

pubmed, article, cancer, google, scholar, cas, central, cell, foxcas, gastric, rna, lncrna, foxc, huang, noncoding, zhang, chen, mrna, promotes, res, nsun, cells, liu, long, proliferation, research, expression, yang, httpsdoiorgs, privacy, cookies, content, data, information, human, yan, access, progression, activation, rnas, wang, sun, consent, publish, search, association, role, survival, patients, methyltransferase,

Topics {✒️}

akt-yb1-mdr1 signaling pathway month download article/chapter fak signal pathway eif3j-dt induces chemoresistance long noncoding rna long noncoding rnas nationwide population-based study rna methyltransferase nsun2 lncrna foxd2-as1 promotes cell proliferation foxc2-as1 attenuated foxc2-as1 showed foxc2-as1 interacted foxc2-as1 acted stabilizing foxc2 mrna full article pdf predicts poor prognosis 5-methylcytosine promotes pathogenesis foxc2-as1 expression psi rna modifications multiple human cancers coding rnas mirnas privacy choices/manage cookies m5c-dependent manner gastric cancer carcinogenesis cell proliferation program attenuated tumor microenvironment lncrna-dependent mechanisms aberrant nsun2-mediated mir-375/ybx1 axis foxc2 mrna gastric cancer tumorigenesis remains largely unknown nat rev genet foxc2-as1 stabilize zeb1 expression cell death dis nat cell biol article yan c-dependent manner jianfa lv conditions privacy policy human cell 34 advanced gastric cancer european economic area advanced tnm stage lncrna-mediated regulation endogenous microrna sponges inhibiting autophagic flux natural science foundation

Schema {🗺️}

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         description:Long noncoding RNA (lncRNA) FOXC2-AS1 has been reported to act as an oncogene in multiple human cancers. However, the clinical significance, functional role and underlying mechanism of FOXC2-AS1 in gastric cancer (GC) remains largely unknown. Here, we found that FOXC2-AS1 expression was significantly elevated in GC tissues and cells, and overexpression of FOXC2-AS1 indicated advanced TNM stage and shorter overall survival in GC patients. Functionally, knockdown of FOXC2-AS1 attenuated the proliferation, migration and invasion of GC cells, whereas overexpression of FOXC2-AS1 showed the opposite effects. Further investigation revealed that FOXC2-AS1 interacted with FOXC2 mRNA and repressed its degradation. FOXC2-AS1 recruited RNA methyltransferase NSUN2 to FOXC2 mRNA, increasing its m5C level and association with YBX1. Taken together, our findings suggested that FOXC2-AS1 acted as an oncogenic lncRNA by stabilizing FOXC2 mRNA in an m5C-dependent manner, which may provide a novel therapeutic target for GC.
         datePublished:2021-07-29T00:00:00Z
         dateModified:2021-07-29T00:00:00Z
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            Cell Biology
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            Surgery
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      headline:FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells
      description:Long noncoding RNA (lncRNA) FOXC2-AS1 has been reported to act as an oncogene in multiple human cancers. However, the clinical significance, functional role and underlying mechanism of FOXC2-AS1 in gastric cancer (GC) remains largely unknown. Here, we found that FOXC2-AS1 expression was significantly elevated in GC tissues and cells, and overexpression of FOXC2-AS1 indicated advanced TNM stage and shorter overall survival in GC patients. Functionally, knockdown of FOXC2-AS1 attenuated the proliferation, migration and invasion of GC cells, whereas overexpression of FOXC2-AS1 showed the opposite effects. Further investigation revealed that FOXC2-AS1 interacted with FOXC2 mRNA and repressed its degradation. FOXC2-AS1 recruited RNA methyltransferase NSUN2 to FOXC2 mRNA, increasing its m5C level and association with YBX1. Taken together, our findings suggested that FOXC2-AS1 acted as an oncogenic lncRNA by stabilizing FOXC2 mRNA in an m5C-dependent manner, which may provide a novel therapeutic target for GC.
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         YBX1
         Cell Biology
         Oncology
         Surgery
         Gynecology
         Reproductive Medicine
         Stem Cells
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