We are analyzing https://link.springer.com/article/10.1007/s13402-024-00923-z.

Title:
Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis | Cellular Oncology
Description:
Background Metastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion are important factors in cancer metastasis. Metastasis is characterized by actin polymerization and depolymerization, which are precisely regulated by molecular changes involving a plethora of actin regulators, including actin-binding proteins (ABPs) and signalling pathways, that enable cancer cell dissemination from the primary tumour. Research on deubiquitinating enzymes (DUBs) has revealed their vital roles in actin dynamics and actin-based migration and invasion during cancer metastasis. Conclusion Here, we review how DUBs drive tumour metastasis by participating in actin rearrangement and actin-based migration and invasion. We summarize the well-characterized and essential actin cytoskeleton signalling molecules related to DUBs, including Rho GTPases, Src kinases, and ABPs such as cofilin and cortactin. Other DUBs that modulate actin-based migration signalling pathways are also discussed. Finally, we discuss and address therapeutic opportunities and ongoing challenges related to DUBs with respect to actin dynamics.
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Keywords {🔍}

pubmed, article, scholar, google, cas, cell, central, cancer, zhang, liu, metastasis, wang, chen, usp, promotes, biol, mol, migration, actin, res, yang, huang, carcinoma, cells, zhou, deubiquitinating, nat, sci, tumor, regulates, zhao, sun, deubiquitinase, kim, progression, pathway, zhu, breast, invasion, signaling, protein, hepatocellular, lee, cortactin, rev, gao, deubiquitination, inhibits, luo, growth,

Topics {✒️}

mirna-539-3p/usp13/mitf/axl signals usp33/slit2/robo1 signalling pathway ca2+-dependent rhoa-myosin signaling ubiquitin-specific peptidase 2a month download article/chapter c-terminal src kinase β-catenin/tcf pathway drosophila usp22/nonstop polarizes usp51-zeb1-dependent deubiquitination mechanism extracellular signal-regulated kinase deubiquitinating enzyme usp33/vdu1 uch-l1 deubiquitinating activity nf-κb pathway inactivation zranb1 enhances stem-cell deubiquitinating tgf-β receptors enhances mesenchymal-epithelial transition multifaceted actin-binding protein blocking pi3k/akt signaling ubiquitin-specific protease 42 including actin-binding proteins erk/mapk signaling pathway c-src-mediated phosphorylation barbed end-bound insertin actin depolymerizing factor/cofilin lysosome-targeting chimeras evolve akt/mtor signaling pathway ubiquitin specific peptidase β1-integrin signaling pathways actin-based cell migration selective small-molecule inhibitors counteracting uchl3-mediated deubiquitination src-family protein kinases actin nucleation-promoting factors activating erk/mtor pathway usp11 promotes growth usp11 promotes epithelial deubiquitinase fam/usp9x interacts deubiquitinase usp13 promotes usp10 promotes proliferation c-fos protein oncogenic/tumor-suppressive status slit2-robo1 signalling tgf-β signaling ubiquitin-proteasome pathway ligase activity-dependent squamous cell carcinoma promotes breast carcinogenesis actin binding proteins actin-binding proteins stabilizes β-catenin

Questions {❓}

Ramakrishna, Deubiquitinating enzymes as cancer biomarkers: new therapeutic opportunities?
Tang, Actin-based protrusions: promoters or inhibitors of cancer invasion?

Schema {🗺️}

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         description:Metastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion are important factors in cancer metastasis. Metastasis is characterized by actin polymerization and depolymerization, which are precisely regulated by molecular changes involving a plethora of actin regulators, including actin-binding proteins (ABPs) and signalling pathways, that enable cancer cell dissemination from the primary tumour. Research on deubiquitinating enzymes (DUBs) has revealed their vital roles in actin dynamics and actin-based migration and invasion during cancer metastasis. Here, we review how DUBs drive tumour metastasis by participating in actin rearrangement and actin-based migration and invasion. We summarize the well-characterized and essential actin cytoskeleton signalling molecules related to DUBs, including Rho GTPases, Src kinases, and ABPs such as cofilin and cortactin. Other DUBs that modulate actin-based migration signalling pathways are also discussed. Finally, we discuss and address therapeutic opportunities and ongoing challenges related to DUBs with respect to actin dynamics.
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            Tumor metastasis
            Cancer Research
            Biomedicine
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            Oncology
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      description:Metastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion are important factors in cancer metastasis. Metastasis is characterized by actin polymerization and depolymerization, which are precisely regulated by molecular changes involving a plethora of actin regulators, including actin-binding proteins (ABPs) and signalling pathways, that enable cancer cell dissemination from the primary tumour. Research on deubiquitinating enzymes (DUBs) has revealed their vital roles in actin dynamics and actin-based migration and invasion during cancer metastasis. Here, we review how DUBs drive tumour metastasis by participating in actin rearrangement and actin-based migration and invasion. We summarize the well-characterized and essential actin cytoskeleton signalling molecules related to DUBs, including Rho GTPases, Src kinases, and ABPs such as cofilin and cortactin. Other DUBs that modulate actin-based migration signalling pathways are also discussed. Finally, we discuss and address therapeutic opportunities and ongoing challenges related to DUBs with respect to actin dynamics.
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         Actin dynamics
         Actin-binding proteins
         Tumor metastasis
         Cancer Research
         Biomedicine
         general
         Pathology
         Oncology
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