We are analyzing https://link.springer.com/article/10.1007/s13277-016-5021-2.

Title:
Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells | Tumor Biology
Description:
Discoidin domain receptor I (DDR1) is confirmed as a receptor tyrosine kinase (RTK), which plays a consequential role in a variety of cancers. Nevertheless, the influence of DDR1 expression and development in renal clear cell carcinoma (RCCC) are still not well corroborated. In our research, we firstly discovered that the expression level of DDR1 was remarkable related to TNM stage (p = 0.032), depth of tumor invasion (p = 0.047), and lymph node metastasis (p = 0.034) in 119 RCCC tissue samples using tissue microarray. The function of DDR1 was then evaluated in vitro using collagen I and DDR1 small interfering RNA (siRNA) to regulate the expression of DDR1 in OS-RC-2 and ACHN renal cancer cells (RCC). DDR1 expression correlated with increased RCC cell migration, invasion, and angiogenesis. Further study revealed that high expression of DDR1 can result in epithelial to mesenchymal transition (EMT) activation. Western blot assay showed that the N-cadherin protein and vimentin were induced while E-cadherin was reduced after DDR1 over expression. Our results suggest that DDR1 is both a prognostic marker for RCCC and a potential functional target for therapy.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, receptor, cell, discoidin, ddr, domain, expression, central, tyrosine, biol, renal, cells, kinase, carcinoma, matrix, tumor, transition, metastasis, invasion, clin, exp, jiangsu, development, collagen, epithelialmesenchymal, vogel, res, human, privacy, cookies, content, research, liu, junnian, zheng, kinases, receptors, int, mol, med, xuzhou, function, information, publish, search,

Topics {✒️}

month download article/chapter zoledronate-treated pc3 cells discoidin domain receptors jak2-erk1/2-mediated mechanism triple-negative breast cancer renal cell carcinoma receptor tyrosine kinase membrane-type matrix metalloproteinases renal cancer cells breast carcinoma cells full article pdf nonintegrin collagen receptors epithelial-mesenchymal transition er hepatocellular carcinoma cells privacy choices/manage cookies extracellular discoidin i postdoctoral research funds related subjects kinase-deficient variants published randomised trials n-cadherin protein article song assoc cancer res human gastric cancer mol cell biol sensing extracellular matrix clin cancer res pancreatic ductal adenocarcinoma angiogenic growth factors soc exp biol human brain tumors tumor biology junnian zheng promotes cell invasion european economic area retroviral insertional mutagenesis rat hippocampal neurons distinct structural characteristics arterial wound repair talent peaks project ethics declarations conflicts article log cancer metastasis rev conditions privacy policy exp ther med vogel wf small molecule inhibitors collagen i-mediated jiangsu planned projects potential functional target

Schema {🗺️}

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         description:Discoidin domain receptor I (DDR1) is confirmed as a receptor tyrosine kinase (RTK), which plays a consequential role in a variety of cancers. Nevertheless, the influence of DDR1 expression and development in renal clear cell carcinoma (RCCC) are still not well corroborated. In our research, we firstly discovered that the expression level of DDR1 was remarkable related to TNM stage (p = 0.032), depth of tumor invasion (p = 0.047), and lymph node metastasis (p = 0.034) in 119 RCCC tissue samples using tissue microarray. The function of DDR1 was then evaluated in vitro using collagen I and DDR1 small interfering RNA (siRNA) to regulate the expression of DDR1 in OS-RC-2 and ACHN renal cancer cells (RCC). DDR1 expression correlated with increased RCC cell migration, invasion, and angiogenesis. Further study revealed that high expression of DDR1 can result in epithelial to mesenchymal transition (EMT) activation. Western blot assay showed that the N-cadherin protein and vimentin were induced while E-cadherin was reduced after DDR1 over expression. Our results suggest that DDR1 is both a prognostic marker for RCCC and a potential functional target for therapy.
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            Renal cancer cells
            Cancer Research
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      description:Discoidin domain receptor I (DDR1) is confirmed as a receptor tyrosine kinase (RTK), which plays a consequential role in a variety of cancers. Nevertheless, the influence of DDR1 expression and development in renal clear cell carcinoma (RCCC) are still not well corroborated. In our research, we firstly discovered that the expression level of DDR1 was remarkable related to TNM stage (p = 0.032), depth of tumor invasion (p = 0.047), and lymph node metastasis (p = 0.034) in 119 RCCC tissue samples using tissue microarray. The function of DDR1 was then evaluated in vitro using collagen I and DDR1 small interfering RNA (siRNA) to regulate the expression of DDR1 in OS-RC-2 and ACHN renal cancer cells (RCC). DDR1 expression correlated with increased RCC cell migration, invasion, and angiogenesis. Further study revealed that high expression of DDR1 can result in epithelial to mesenchymal transition (EMT) activation. Western blot assay showed that the N-cadherin protein and vimentin were induced while E-cadherin was reduced after DDR1 over expression. Our results suggest that DDR1 is both a prognostic marker for RCCC and a potential functional target for therapy.
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         EMT
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         Cancer Research
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