We are analyzing https://link.springer.com/article/10.1007/s13277-013-1220-2.

Title:
Diagnostic value of pleural interleukin 17 and carcinoembryonic antigen in lung cancer patients with malignant pleural effusions | Tumor Biology
Description:
Interleukin 17 (IL-17) has been found to be increased in some human cancers; however, the possible implication of IL-17 in regulating antitumor responses in lung cancer patients with malignant pleural effusions (MPE) remains to be elucidated. This study aimed to investigate the diagnostic value of pleural IL-17 and carcinoembryonic antigen (CEA) in MPE and benign pleural effusions (BPE). Pleural effusion samples from 108 patients were classified on the basis of diagnosis as MPE (n = 56) and BPE (n = 52). The concentration of IL-17 was determined by enzyme-linked immunosorbent assay (ELISA). The CEA levels were also determined in all patients. A significant difference was observed in the levels of CEA (P < 0.01) between MPE and BPE. The concentration of IL-17 in MPE was significantly higher compared to that in BPE (P < 0.01). With a cutoff point of 15.7 pg/ml, IL-17 had a sensitivity of 76.8 % and a specificity of 80.8 % for differential diagnosis. The combined detection of IL-17 and CEA had a sensitivity of 96.4 % and a specificity of 92.3 % to distinguish MPE from BPE. The combined detection of IL-17 and CEA may be more valuable in the differential diagnosis between MPE and BPE.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

article, pleural, pubmed, google, scholar, malignant, cas, cancer, effusion, effusions, diagnostic, interleukin, cells, antigen, carcinoembryonic, lung, patients, mpe, diagnosis, tuberculous, med, tumor, bpe, access, privacy, cookies, content, zhang, human, cea, wang, central, publish, research, search, zhan, differentiation, yang, res, immunol, nanjing, data, information, log, journal, biology, september, xiuwei, benign, levels,

Topics {✒️}

month download article/chapter transforming growth factor-beta diagnostic molecular biomarkers enzyme-linked immunosorbent assay benign pleural effusions il-6-stat3 signaling pathway li-ke yu xiu-wei zhang malignant pleural effusion pleural effusion samples pleural effusion control full article pdf related subjects malignant pleural effusions malignant pleural effusions human cd4+ il-17-producing tuberculous pleural effusion promote tumor growth privacy choices/manage cookies interleukin 17-producing human human tumor environments lung cancer patients tuberculous pleural effusions thoracoscopic pleural biopsies pleural lavage fluid article xu cd4+cd 25+ foxp3+ pleural effusion carcinoembryonic antigen level european economic area regulating antitumor responses significantly higher compared check access emel'ianov mn kol'tsov ki abou chaz mb lap-dependent mechanism o'shea jj instant access conditions privacy policy cd4+cd25+ regulatory nonspecific pleuritis/fibrosis thorac cardiovasc surg abd el rahman helper cells tuberculous exudative pleurisy annu rev immunol clin cancer res pleural interleukin 17 accepting optional cookies

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Diagnostic value of pleural interleukin 17 and carcinoembryonic antigen in lung cancer patients with malignant pleural effusions
         description:Interleukin 17 (IL-17) has been found to be increased in some human cancers; however, the possible implication of IL-17 in regulating antitumor responses in lung cancer patients with malignant pleural effusions (MPE) remains to be elucidated. This study aimed to investigate the diagnostic value of pleural IL-17 and carcinoembryonic antigen (CEA) in MPE and benign pleural effusions (BPE). Pleural effusion samples from 108 patients were classified on the basis of diagnosis as MPE (n = 56) and BPE (n = 52). The concentration of IL-17 was determined by enzyme-linked immunosorbent assay (ELISA). The CEA levels were also determined in all patients. A significant difference was observed in the levels of CEA (P < 0.01) between MPE and BPE. The concentration of IL-17 in MPE was significantly higher compared to that in BPE (P < 0.01). With a cutoff point of 15.7 pg/ml, IL-17 had a sensitivity of 76.8 % and a specificity of 80.8 % for differential diagnosis. The combined detection of IL-17 and CEA had a sensitivity of 96.4 % and a specificity of 92.3 % to distinguish MPE from BPE. The combined detection of IL-17 and CEA may be more valuable in the differential diagnosis between MPE and BPE.
         datePublished:2013-09-26T00:00:00Z
         dateModified:2013-09-26T00:00:00Z
         pageStart:1599
         pageEnd:1603
         sameAs:https://doi.org/10.1007/s13277-013-1220-2
         keywords:
            Interleukin 17Carcinoembryonic antigen
            Lung cancer
            Malignant pleural effusion
            Benign pleural effusion
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-013-1220-2/MediaObjects/13277_2013_1220_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-013-1220-2/MediaObjects/13277_2013_1220_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-013-1220-2/MediaObjects/13277_2013_1220_Fig3_HTML.gif
         isPartOf:
            name:Tumor Biology
            issn:
               1423-0380
               1010-4283
            volumeNumber:35
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Chun-Hua Xu
               affiliation:
                     name:Nanjing Chest Hospital
                     address:
                        name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ping Zhan
               affiliation:
                     name:Nanjing Chest Hospital
                     address:
                        name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Li-Ke Yu
               affiliation:
                     name:Nanjing Chest Hospital
                     address:
                        name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Xiu-Wei Zhang
               affiliation:
                     name:Nanjing Jiangning Hospital
                     address:
                        name:Department of Respiratory Medicine, Nanjing Jiangning Hospital, Nanjing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Diagnostic value of pleural interleukin 17 and carcinoembryonic antigen in lung cancer patients with malignant pleural effusions
      description:Interleukin 17 (IL-17) has been found to be increased in some human cancers; however, the possible implication of IL-17 in regulating antitumor responses in lung cancer patients with malignant pleural effusions (MPE) remains to be elucidated. This study aimed to investigate the diagnostic value of pleural IL-17 and carcinoembryonic antigen (CEA) in MPE and benign pleural effusions (BPE). Pleural effusion samples from 108 patients were classified on the basis of diagnosis as MPE (n = 56) and BPE (n = 52). The concentration of IL-17 was determined by enzyme-linked immunosorbent assay (ELISA). The CEA levels were also determined in all patients. A significant difference was observed in the levels of CEA (P < 0.01) between MPE and BPE. The concentration of IL-17 in MPE was significantly higher compared to that in BPE (P < 0.01). With a cutoff point of 15.7 pg/ml, IL-17 had a sensitivity of 76.8 % and a specificity of 80.8 % for differential diagnosis. The combined detection of IL-17 and CEA had a sensitivity of 96.4 % and a specificity of 92.3 % to distinguish MPE from BPE. The combined detection of IL-17 and CEA may be more valuable in the differential diagnosis between MPE and BPE.
      datePublished:2013-09-26T00:00:00Z
      dateModified:2013-09-26T00:00:00Z
      pageStart:1599
      pageEnd:1603
      sameAs:https://doi.org/10.1007/s13277-013-1220-2
      keywords:
         Interleukin 17Carcinoembryonic antigen
         Lung cancer
         Malignant pleural effusion
         Benign pleural effusion
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-013-1220-2/MediaObjects/13277_2013_1220_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-013-1220-2/MediaObjects/13277_2013_1220_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-013-1220-2/MediaObjects/13277_2013_1220_Fig3_HTML.gif
      isPartOf:
         name:Tumor Biology
         issn:
            1423-0380
            1010-4283
         volumeNumber:35
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Chun-Hua Xu
            affiliation:
                  name:Nanjing Chest Hospital
                  address:
                     name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ping Zhan
            affiliation:
                  name:Nanjing Chest Hospital
                  address:
                     name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Li-Ke Yu
            affiliation:
                  name:Nanjing Chest Hospital
                  address:
                     name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Xiu-Wei Zhang
            affiliation:
                  name:Nanjing Jiangning Hospital
                  address:
                     name:Department of Respiratory Medicine, Nanjing Jiangning Hospital, Nanjing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Tumor Biology
      issn:
         1423-0380
         1010-4283
      volumeNumber:35
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Nanjing Chest Hospital
      address:
         name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
         type:PostalAddress
      name:Nanjing Chest Hospital
      address:
         name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
         type:PostalAddress
      name:Nanjing Chest Hospital
      address:
         name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
         type:PostalAddress
      name:Nanjing Jiangning Hospital
      address:
         name:Department of Respiratory Medicine, Nanjing Jiangning Hospital, Nanjing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Chun-Hua Xu
      affiliation:
            name:Nanjing Chest Hospital
            address:
               name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Ping Zhan
      affiliation:
            name:Nanjing Chest Hospital
            address:
               name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Li-Ke Yu
      affiliation:
            name:Nanjing Chest Hospital
            address:
               name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Xiu-Wei Zhang
      affiliation:
            name:Nanjing Jiangning Hospital
            address:
               name:Department of Respiratory Medicine, Nanjing Jiangning Hospital, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
      name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
      name:First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
      name:Department of Respiratory Medicine, Nanjing Jiangning Hospital, Nanjing, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(104)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.82s.

LINK . SPRINGER . COM {}