We are analyzing https://link.springer.com/article/10.1007/s13277-013-0895-8.

Title:
Prognostic significance of mammalian sterile 20-like kinase 1 in breast cancer | Tumor Biology
Description:
Mammalian sterile 20-like kinase 1 (Mst1) has been proved in the process of apoptosis and tumor suppression. The aim of the study was to investigate the expression of Mst1 in breast cancer and to evaluate its prognostic significance. The expression of Mst1 was examined in 110 breast cancer patients by immunohistochemistry, in which 80 (72.7 %) were defined as positive for Mst1 expression. Patients with negative expression of Mst1 had poor overall survival, comparing with those with positive expression using Kaplan–Meier survival analysis (P = 0.009). Multivariate analysis using Cox proportional hazards model showed that Mst1 expression was a significant independent prognostic factor in breast cancer (P = 0.030). Our results presented the tumor suppressive role of Mst1, and confirmed Mst1 was a prognostic factor in human breast cancer.
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Keywords {🔍}

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Topics {✒️}

article google scholar month download article/chapter triple-negative breast cancer kaplan–meier survival analysis related subjects full article pdf mst1-jnk promotes apoptosis human breast cancer privacy choices/manage cookies proapoptotic kinase mst1 hippo pathway caspase cleavage products article lin tumor suppressor rassf1a mst1-mediated apoptosis caspase-mediated activation qifeng yang european economic area high nuclear msk1 thiol-specific peroxidases graves jd extends life span organ size control soft tissue sarcoma check access instant access breast cancer human protein kinase tumor suppressive role conditions privacy policy antioxid redox signal article log cancer cell author information authors protein kinases accepting optional cookies article cite main content log cheng xu ovarian cancers prognostic significance journal finder publish cancer res fengfeng cai xiaoli kong estrogen receptor prognostic factor colorectal cancer longer survival breast surgery

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         description:Mammalian sterile 20-like kinase 1 (Mst1) has been proved in the process of apoptosis and tumor suppression. The aim of the study was to investigate the expression of Mst1 in breast cancer and to evaluate its prognostic significance. The expression of Mst1 was examined in 110 breast cancer patients by immunohistochemistry, in which 80 (72.7 %) were defined as positive for Mst1 expression. Patients with negative expression of Mst1 had poor overall survival, comparing with those with positive expression using Kaplan–Meier survival analysis (P = 0.009). Multivariate analysis using Cox proportional hazards model showed that Mst1 expression was a significant independent prognostic factor in breast cancer (P = 0.030). Our results presented the tumor suppressive role of Mst1, and confirmed Mst1 was a prognostic factor in human breast cancer.
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