We are analyzing https://link.springer.com/article/10.1007/s13238-012-2083-9.

Title:
New components of the necroptotic pathway | Protein & Cell
Description:
Programmed necrosis, also known as necroptosis, has recently drawn great attention. As an important cellular regulation mechanism, knowledge of its signaling components is expanding. Necroptosisis demonstrated to be regulated by the RIP1 and RIP3 kinases, and its pathophysiological importance has been confirmed in a number of disease models. Here we review the new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI, and discuss some of their possible applications according to recent findings.
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Keywords {🔍}

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Topics {✒️}

prevent bax/bak-dependent apoptosis protein serine/threonine phosphatase tnf-r1 signaling complex nf-kappab activation [corrected] bak-induced mitochondrial fission victor han & jiahuai han rip3-driven regulated necrosis caspase-independent cell death tnf-mediated gene induction rip1/rip3 necrosome forms phosphorylation-driven assembly mitochondrial death/life regulator rip3-dependent necrosis caspase-dependent necrosis tumor necrosis factor tnf-alpha induces death domain protein bcl-xl block apoptosis tnf-induced necrosis tnf induced necroptosis tnf-induced necroptosis prevents skin inflammation dynamin-related protein 1 article google scholar interferon induces necroptosis multiple tnfr1 complex dai/zbp1/dlm-1 complexes virus-induced inflammation privacy choices/manage cookies specific cellular target caspase-8 protects mice innate immune response mammalian mitochondrial fission mitochondrial fission machinery grim-19 mediated translocation promote rip1 ubiquitination sequential signaling complexes ordered cellular explosion inflammation-related hepatocarcinogenesis cellular stress biology caspase-8-deficient mice rip3 kinases main content log therapeutic potential energy metabolism regulator nonapoptotic cell death cell death subroutines cell death differ chronic intestinal inflammation european economic area

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Necrostatin: a potentially novel cardioprotective agent?

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         description:Programmed necrosis, also known as necroptosis, has recently drawn great attention. As an important cellular regulation mechanism, knowledge of its signaling components is expanding. Necroptosisis demonstrated to be regulated by the RIP1 and RIP3 kinases, and its pathophysiological importance has been confirmed in a number of disease models. Here we review the new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI, and discuss some of their possible applications according to recent findings.
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