We are analyzing https://link.springer.com/article/10.1007/s13205-023-03863-x.

Title:
LncRNA BCRT1 depletion suppresses cervical cancer cell growth via sponging miR-432-5p/CCR7 axis | 3 Biotech
Description:
Breast cancer-related transcript 1 (BCRT1), a lncRNA that is overexpressed in several human cancers, facilitates the progression of breast cancer and osteosarcoma. Nevertheless, the function of BCRT1 in cervical cancer (CC) still remains unknown. In this study, BCRT1 was significantly overexpressed in CC tissues and correlated with the advanced stage of CC patients. BCRT1 depletion dampened CC cell proliferation, and drives cell apoptosis and cell cycle inhibition. Mechanistically, BCRT1 bound miR-432-5p and negatively modulated miR-432-5p’s expression in CC cells. Reduced miR-452-3p expression was observed in CC tissues and exerted tumor suppressive function in CC cell growth. Further mechanism study revealed that CCR7 was clarified as a target of miR-432-5p and was inhibited following BCRT1 depletion. CCR7 transfection could recover CC cell growth that was suppressed with BCRT1 down-regulation. These results revealed the novel function of BCRT1/miR-432-5p/CCR7 pathway in CC, suggesting BCRT1 might be a potential biomarker and target for CC treatment.
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Keywords {🔍}

article, cancer, pubmed, google, scholar, cas, cervical, cell, noncoding, bcrt, long, central, shanxi, rna, wang, breast, mirp, microrna, medical, hospital, growth, axis, yang, expression, ccr, rnas, biology, targeting, privacy, cookies, content, data, lncrna, sponging, progression, access, nature, med, invasion, rev, function, information, publish, search, depletion, author, mol, res, zhao, zhang,

Topics {✒️}

circfkbp8/mir-432-5p/e2f7 cascade functions sponging mir-432-5p/ccr7 axis mir-193a-5p/pin1 signaling bcrt1/mir-432-5p/ccr7 pathway mir-432-5p/e2f6 axis month download article/chapter sponging mir-20a-5p bcrt1 bound mir-432-5p long noncoding rna negatively modulated mir-432-5p microrna-432-5p regulates sprouting regulating mir-1303/fgf7 axis hpv-negative cervical cancer reduced mir-452-3p expression targeting mir-1303/ptbp3 axis regulating mir-432–5p/mcl1 cc cell growth lncrna-mediated regulation sponging mir-138-5p sponging mir-942-5p full article pdf bcrt1 depletion competitive endogenous rna writing-original draft targeting mir-432-5p privacy choices/manage cookies cell cycle inhibition metastatic cervical cancer coding rnas mirnas drives cell apoptosis western medicine hospital related subjects article wang accepted manuscript version shanxi medical university xiangdong bai holds exclusive rights shanxi province european economic area upregulating macc1 expression lymph node metastasis davalos-misslitz ac synthetic microrna biology endogenous microrna sponges genome-wide approaches circ-cep128 enhances mir-432-5p cell signaling conditions privacy policy jiefang south road

Schema {🗺️}

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         headline:LncRNA BCRT1 depletion suppresses cervical cancer cell growth via sponging miR-432-5p/CCR7 axis
         description:Breast cancer-related transcript 1 (BCRT1), a lncRNA that is overexpressed in several human cancers, facilitates the progression of breast cancer and osteosarcoma. Nevertheless, the function of BCRT1 in cervical cancer (CC) still remains unknown. In this study, BCRT1 was significantly overexpressed in CC tissues and correlated with the advanced stage of CC patients. BCRT1 depletion dampened CC cell proliferation, and drives cell apoptosis and cell cycle inhibition. Mechanistically, BCRT1 bound miR-432-5p and negatively modulated miR-432-5p’s expression in CC cells. Reduced miR-452-3p expression was observed in CC tissues and exerted tumor suppressive function in CC cell growth. Further mechanism study revealed that CCR7 was clarified as a target of miR-432-5p and was inhibited following BCRT1 depletion. CCR7 transfection could recover CC cell growth that was suppressed with BCRT1 down-regulation. These results revealed the novel function of BCRT1/miR-432-5p/CCR7 pathway in CC, suggesting BCRT1 might be a potential biomarker and target for CC treatment.
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      description:Breast cancer-related transcript 1 (BCRT1), a lncRNA that is overexpressed in several human cancers, facilitates the progression of breast cancer and osteosarcoma. Nevertheless, the function of BCRT1 in cervical cancer (CC) still remains unknown. In this study, BCRT1 was significantly overexpressed in CC tissues and correlated with the advanced stage of CC patients. BCRT1 depletion dampened CC cell proliferation, and drives cell apoptosis and cell cycle inhibition. Mechanistically, BCRT1 bound miR-432-5p and negatively modulated miR-432-5p’s expression in CC cells. Reduced miR-452-3p expression was observed in CC tissues and exerted tumor suppressive function in CC cell growth. Further mechanism study revealed that CCR7 was clarified as a target of miR-432-5p and was inhibited following BCRT1 depletion. CCR7 transfection could recover CC cell growth that was suppressed with BCRT1 down-regulation. These results revealed the novel function of BCRT1/miR-432-5p/CCR7 pathway in CC, suggesting BCRT1 might be a potential biomarker and target for CC treatment.
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         Biotechnology
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         Cancer Research
         Bioinformatics
         Stem Cells
         Biomaterials
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