We are analyzing https://link.springer.com/article/10.1007/s13205-022-03162-x.

Title:
A review on cullin neddylation and strategies to identify its inhibitors for cancer therapy | 3 Biotech
Description:
The cullin-RING E3 ligases (CRLs) are the biggest components of the E3 ubiquitin ligase protein family, and they represent an essential role in various diseases that occur because of abnormal activation, particularly in tumors development. Regulation of CRLs needs neddylation, a post-translational modification involving an enzymatic cascade that transfers small, ubiquitin-like NEDD8 protein to CRLs. Many previous studies have confirmed neddylation as an enticing target for anticancer drug discoveries, and few recent studies have also found a significant increase in advancement in protein neddylation, including preclinical and clinical target validation to discover the neddylation inhibitor compound. In the present review, we first presented briefly the essence of CRLs
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,016 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, cancer, neddylation, cell, ubiquitin, protein, liu, inhibitor, targeting, httpsdoiorgs, biol, mol, chem, nedd, enzyme, drug, wang, med, zhang, cullin, inhibitors, ligases, ligase, sci, therapy, development, target, treatment, research, cullinring, crls, regulation, discovery, system, int, front, chen, nat, cancers, neddactivating, zhao, role, chapter, pathway, degradation,

Topics {✒️}

scf–rbr e3–e3 super-assembly inhibiting pi3k/akt/mtor signaling month download article/chapter cullin-ring e3 ligases ubiquitin-proteasome-dependent dvl2 degradation ubiquitin/proteasome-directed protein degradation cul3-based e3 ligase inactivate cullin-ring ligases small-molecule-induced protein degradation cullin-ring ubiquitin ligases de esch ij time-resolved fluorescence capabilities nf-κb-dependent lymphoma nf-κb-ccl2 signaling targeting rna-binding proteins proteasome inhibitor-related cardiotoxicity higher-risk mds/cmml structure-based virtual screening polyubiquitin linkage-specific antibodies nedd8-activating enzyme inhibitor cullin–ring ligases marek kieliszek e3 ubiquitin ligase f-box protein targets stem-loop binding protein computational methods-guided design e3 ligase guide post-translational modification involving nedd8-activating enzyme inhibitors full article pdf cul4a ubiquitin ligase c-myc-mediated regulation rna-binding proteins targeting pan-essential genes tumor suppressor p53 proietti-de-santis author information authors class protein degraders drug delivery systems privacy choices/manage cookies nedd8-activating enzyme north university center ubiquitin-activating enzyme ubiquitin activating enzyme small-molecule inhibitor small molecule inhibitor target-based design protein-based nanoparticles quantum state resolution article bano

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A review on cullin neddylation and strategies to identify its inhibitors for cancer therapy
         description:The cullin-RING E3 ligases (CRLs) are the biggest components of the E3 ubiquitin ligase protein family, and they represent an essential role in various diseases that occur because of abnormal activation, particularly in tumors development. Regulation of CRLs needs neddylation, a post-translational modification involving an enzymatic cascade that transfers small, ubiquitin-like NEDD8 protein to CRLs. Many previous studies have confirmed neddylation as an enticing target for anticancer drug discoveries, and few recent studies have also found a significant increase in advancement in protein neddylation, including preclinical and clinical target validation to discover the neddylation inhibitor compound. In the present review, we first presented briefly the essence of CRLs' neddylation and its control, systematic analysis of CRLs, followed by the description of a few recorded chemical inhibitors of CRLs neddylation enzymes with recent examples of preclinical and clinical targets. We have also listed various structure-based pointing of protein–protein dealings in the CRLs' neddylation reaction, and last, the methods available to discover new inhibitors of neddylation are elaborated. This review will offer a concentrated, up-to-date, and detailed description of the discovery of neddylation inhibitors.
         datePublished:2022-03-29T00:00:00Z
         dateModified:2022-03-29T00:00:00Z
         pageStart:1
         pageEnd:18
         sameAs:https://doi.org/10.1007/s13205-022-03162-x
         keywords:
            Neddylation
            Cancer
            NEDD8
            Inhibitor
            Cullin-RING E3 ligase
            Biotechnology
            Agriculture
            Cancer Research
            Bioinformatics
            Stem Cells
            Biomaterials
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig6_HTML.png
         isPartOf:
            name:3 Biotech
            issn:
               2190-5738
               2190-572X
            volumeNumber:12
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Iqra Bano
               affiliation:
                     name:Shaheed Benazir Bhutto University of Veterinary and Animals Sciences Sakrand (SBBUVAS)
                     address:
                        name:Department of Veterinary Physiology and Biochemistry, Shaheed Benazir Bhutto University of Veterinary and Animals Sciences Sakrand (SBBUVAS), Sakrand, Pakistan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Moolchand Malhi
               affiliation:
                     name:Sindh Agriculture University
                     address:
                        name:Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Min Zhao
               affiliation:
                     name:Zhengzhou University
                     address:
                        name:Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, and Key Laboratory of Advanced Drug Preparation Technologies, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Liviu Giurgiulescu
               affiliation:
                     name:Technical University of Cluj Napoca, North University Center of Baia Mare
                     address:
                        name:Chemistry-Biology Department, Technical University of Cluj Napoca, North University Center of Baia Mare, Baia Mare, Romania
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hira Sajjad
               affiliation:
                     name:Sindh Agriculture University
                     address:
                        name:Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marek Kieliszek
               url:http://orcid.org/0000-0002-5836-4865
               affiliation:
                     name:Warsaw University of Life Sciences-SGGW
                     address:
                        name:Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences-SGGW, Warsaw, Poland
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A review on cullin neddylation and strategies to identify its inhibitors for cancer therapy
      description:The cullin-RING E3 ligases (CRLs) are the biggest components of the E3 ubiquitin ligase protein family, and they represent an essential role in various diseases that occur because of abnormal activation, particularly in tumors development. Regulation of CRLs needs neddylation, a post-translational modification involving an enzymatic cascade that transfers small, ubiquitin-like NEDD8 protein to CRLs. Many previous studies have confirmed neddylation as an enticing target for anticancer drug discoveries, and few recent studies have also found a significant increase in advancement in protein neddylation, including preclinical and clinical target validation to discover the neddylation inhibitor compound. In the present review, we first presented briefly the essence of CRLs' neddylation and its control, systematic analysis of CRLs, followed by the description of a few recorded chemical inhibitors of CRLs neddylation enzymes with recent examples of preclinical and clinical targets. We have also listed various structure-based pointing of protein–protein dealings in the CRLs' neddylation reaction, and last, the methods available to discover new inhibitors of neddylation are elaborated. This review will offer a concentrated, up-to-date, and detailed description of the discovery of neddylation inhibitors.
      datePublished:2022-03-29T00:00:00Z
      dateModified:2022-03-29T00:00:00Z
      pageStart:1
      pageEnd:18
      sameAs:https://doi.org/10.1007/s13205-022-03162-x
      keywords:
         Neddylation
         Cancer
         NEDD8
         Inhibitor
         Cullin-RING E3 ligase
         Biotechnology
         Agriculture
         Cancer Research
         Bioinformatics
         Stem Cells
         Biomaterials
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13205-022-03162-x/MediaObjects/13205_2022_3162_Fig6_HTML.png
      isPartOf:
         name:3 Biotech
         issn:
            2190-5738
            2190-572X
         volumeNumber:12
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Iqra Bano
            affiliation:
                  name:Shaheed Benazir Bhutto University of Veterinary and Animals Sciences Sakrand (SBBUVAS)
                  address:
                     name:Department of Veterinary Physiology and Biochemistry, Shaheed Benazir Bhutto University of Veterinary and Animals Sciences Sakrand (SBBUVAS), Sakrand, Pakistan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Moolchand Malhi
            affiliation:
                  name:Sindh Agriculture University
                  address:
                     name:Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Min Zhao
            affiliation:
                  name:Zhengzhou University
                  address:
                     name:Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, and Key Laboratory of Advanced Drug Preparation Technologies, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Liviu Giurgiulescu
            affiliation:
                  name:Technical University of Cluj Napoca, North University Center of Baia Mare
                  address:
                     name:Chemistry-Biology Department, Technical University of Cluj Napoca, North University Center of Baia Mare, Baia Mare, Romania
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hira Sajjad
            affiliation:
                  name:Sindh Agriculture University
                  address:
                     name:Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marek Kieliszek
            url:http://orcid.org/0000-0002-5836-4865
            affiliation:
                  name:Warsaw University of Life Sciences-SGGW
                  address:
                     name:Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences-SGGW, Warsaw, Poland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:3 Biotech
      issn:
         2190-5738
         2190-572X
      volumeNumber:12
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Shaheed Benazir Bhutto University of Veterinary and Animals Sciences Sakrand (SBBUVAS)
      address:
         name:Department of Veterinary Physiology and Biochemistry, Shaheed Benazir Bhutto University of Veterinary and Animals Sciences Sakrand (SBBUVAS), Sakrand, Pakistan
         type:PostalAddress
      name:Sindh Agriculture University
      address:
         name:Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
         type:PostalAddress
      name:Zhengzhou University
      address:
         name:Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, and Key Laboratory of Advanced Drug Preparation Technologies, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China
         type:PostalAddress
      name:Technical University of Cluj Napoca, North University Center of Baia Mare
      address:
         name:Chemistry-Biology Department, Technical University of Cluj Napoca, North University Center of Baia Mare, Baia Mare, Romania
         type:PostalAddress
      name:Sindh Agriculture University
      address:
         name:Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
         type:PostalAddress
      name:Warsaw University of Life Sciences-SGGW
      address:
         name:Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences-SGGW, Warsaw, Poland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Iqra Bano
      affiliation:
            name:Shaheed Benazir Bhutto University of Veterinary and Animals Sciences Sakrand (SBBUVAS)
            address:
               name:Department of Veterinary Physiology and Biochemistry, Shaheed Benazir Bhutto University of Veterinary and Animals Sciences Sakrand (SBBUVAS), Sakrand, Pakistan
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Moolchand Malhi
      affiliation:
            name:Sindh Agriculture University
            address:
               name:Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
               type:PostalAddress
            type:Organization
      name:Min Zhao
      affiliation:
            name:Zhengzhou University
            address:
               name:Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, and Key Laboratory of Advanced Drug Preparation Technologies, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Liviu Giurgiulescu
      affiliation:
            name:Technical University of Cluj Napoca, North University Center of Baia Mare
            address:
               name:Chemistry-Biology Department, Technical University of Cluj Napoca, North University Center of Baia Mare, Baia Mare, Romania
               type:PostalAddress
            type:Organization
      name:Hira Sajjad
      affiliation:
            name:Sindh Agriculture University
            address:
               name:Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
               type:PostalAddress
            type:Organization
      name:Marek Kieliszek
      url:http://orcid.org/0000-0002-5836-4865
      affiliation:
            name:Warsaw University of Life Sciences-SGGW
            address:
               name:Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences-SGGW, Warsaw, Poland
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Veterinary Physiology and Biochemistry, Shaheed Benazir Bhutto University of Veterinary and Animals Sciences Sakrand (SBBUVAS), Sakrand, Pakistan
      name:Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
      name:Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, and Key Laboratory of Advanced Drug Preparation Technologies, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China
      name:Chemistry-Biology Department, Technical University of Cluj Napoca, North University Center of Baia Mare, Baia Mare, Romania
      name:Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Pakistan
      name:Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences-SGGW, Warsaw, Poland
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(506)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.16s.

LINK . SPRINGER . COM {}