We are analyzing https://link.springer.com/article/10.1007/s12672-025-02510-6.

Title:
Defining the transcriptional routes controlling lncRNA NEAT1 expression: implications in cellular stress response, inflammation, and differentiation | Discover Oncology
Description:
NEAT1 (Nuclear Enriched Abundant Transcript 1) is a long non-coding RNA playing a critical role in both physiological and pathological settings by directly modulating a variety of biological events, including transcriptional regulation, RNA processing, and chromatin remodeling. Multiple evidence demonstrated that different transcription factors and signaling pathways modulate biological processes by tightly regulating NEAT1 expression. These regulatory mechanisms act at different levels, allowing cells to rapidly modulate NEAT1 expression and dynamically respond to sudden changes in cellular conditions. In this review, we summarize and discuss the transcriptional routes controlling NEAT1 expression, emphasizing recent evidence showing the pivotal role of NEAT1 in regulating important biological processes, such as cellular stress response, inflammation, and cell differentiation.
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Keywords {🔍}

neat, pubmed, article, google, scholar, cas, cell, central, expression, paraspeckles, differentiation, response, rna, cells, noncoding, transcription, cellular, long, dna, transcriptional, activation, regulation, role, cancer, protein, damage, proteins, stress, gene, wang, nuclear, factors, genes, repair, zhang, lncrna, chen, inflammation, promoter, human, mol, key, binding, liu, essential, assembly, specific, paraspeckle, factor, formation,

Topics {✒️}

men epsilon/beta nuclear-retained wnt/beta-catenin signaling pathway tlr3/p38-dependent transcriptional activation red t-shaped lines wnt/β-catenin pathway [73] wnt/beta-catenin signaling wnt/beta-catenin pathway article download pdf dna-damaging inducing agents mir-27a/pten axis brm/swi2-related gene 1 modulates p53-induced transactivation oxygen–glucose deprivation/reoxygenation intra-s-phase checkpoint clp-induced septic mice neuronal-glial fate specification confers drug-inducible neuroprotection tss = transcription start site enhance pri-mirna processing rar-related orphan receptor core–shell spheroidal structure mir-128-3p/ nuclear factor lineage-specific differentiation programs noncoding rna-dependent assembly long noncoding rna-neat1 hdac1/2-mediated histone deacetylation isoform-specific knockout mice atra-induced myeloid differentiation hyaluronic acid-related genes recognizes hif-α subunits injury-induced inflammatory response bone marrow-derived macrophages rna-binding protein srsf1 mitochondria-paraspeckle axis regulates hif-2α-dependent transcription neat1-ko female mice triggers anti-tumor activity neat1-dependent biological outcome sequestering rna-binding proteins hif-2α target gene cancer-related mutant forms neat1_2-rnp complexes formed paraspeckle-mediated nuclear retention subpopulation-specific nuclear bodies pml/raralpha-mediated suppression p53-inducible lincrna essential endocytosis-related genes expression tlr4/nf-κb signaling post-translational modifications involved rna editing mediated

Questions {❓}

LncRNA NEAT1 in paraspeckles: a structural scaffold for cellular DNA damage response systems?

Schema {🗺️}

WebPage:
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         description:NEAT1 (Nuclear Enriched Abundant Transcript 1) is a long non-coding RNA playing a critical role in both physiological and pathological settings by directly modulating a variety of biological events, including transcriptional regulation, RNA processing, and chromatin remodeling. Multiple evidence demonstrated that different transcription factors and signaling pathways modulate biological processes by tightly regulating NEAT1 expression. These regulatory mechanisms act at different levels, allowing cells to rapidly modulate NEAT1 expression and dynamically respond to sudden changes in cellular conditions. In this review, we summarize and discuss the transcriptional routes controlling NEAT1 expression, emphasizing recent evidence showing the pivotal role of NEAT1 in regulating important biological processes, such as cellular stress response, inflammation, and cell differentiation.
         datePublished:2025-05-15T00:00:00Z
         dateModified:2025-05-15T00:00:00Z
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            DNA damage
            Cell differentiation
            Inflammation
            Oncology
            Cancer Research
            Surgical Oncology
            Molecular Medicine
            Radiotherapy
            Internal Medicine
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      headline:Defining the transcriptional routes controlling lncRNA NEAT1 expression: implications in cellular stress response, inflammation, and differentiation
      description:NEAT1 (Nuclear Enriched Abundant Transcript 1) is a long non-coding RNA playing a critical role in both physiological and pathological settings by directly modulating a variety of biological events, including transcriptional regulation, RNA processing, and chromatin remodeling. Multiple evidence demonstrated that different transcription factors and signaling pathways modulate biological processes by tightly regulating NEAT1 expression. These regulatory mechanisms act at different levels, allowing cells to rapidly modulate NEAT1 expression and dynamically respond to sudden changes in cellular conditions. In this review, we summarize and discuss the transcriptional routes controlling NEAT1 expression, emphasizing recent evidence showing the pivotal role of NEAT1 in regulating important biological processes, such as cellular stress response, inflammation, and cell differentiation.
      datePublished:2025-05-15T00:00:00Z
      dateModified:2025-05-15T00:00:00Z
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      keywords:
         Transcription factors
         NEAT1
         DNA damage
         Cell differentiation
         Inflammation
         Oncology
         Cancer Research
         Surgical Oncology
         Molecular Medicine
         Radiotherapy
         Internal Medicine
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                     name:Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy
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            affiliation:
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                  address:
                     name:Institute of Translational Pharmacology (IFT), CNR, Rome, Italy
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      affiliation:
            name:University of Rome “Tor Vergata”
            address:
               name:Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy
               type:PostalAddress
            type:Organization
      name:Veronica La Banca
      url:http://orcid.org/0000-0003-0206-8394
      affiliation:
            name:CNR
            address:
               name:Institute of Translational Pharmacology (IFT), CNR, Rome, Italy
               type:PostalAddress
            type:Organization
      name:Silvia D’Amico
      url:http://orcid.org/0000-0002-9805-4589
      affiliation:
            name:CNR
            address:
               name:Institute of Translational Pharmacology (IFT), CNR, Rome, Italy
               type:PostalAddress
            type:Organization
      name:Sara Nicolai
      url:http://orcid.org/0000-0001-8776-1440
      affiliation:
            name:CNR
            address:
               name:Institute of Translational Pharmacology (IFT), CNR, Rome, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Angelo Peschiaroli
      url:http://orcid.org/0000-0001-6311-2382
      affiliation:
            name:CNR
            address:
               name:Institute of Translational Pharmacology (IFT), CNR, Rome, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy
      name:Institute of Translational Pharmacology (IFT), CNR, Rome, Italy
      name:Institute of Translational Pharmacology (IFT), CNR, Rome, Italy
      name:Institute of Translational Pharmacology (IFT), CNR, Rome, Italy
      name:Institute of Translational Pharmacology (IFT), CNR, Rome, Italy

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