We are analyzing https://link.springer.com/article/10.1007/s12672-025-02150-w.

Title:
Hypoxia signaling in cancer: HIF-1α stimulated by COVID-19 can lead to cancer progression and chemo-resistance in oral squamous cell carcinoma (OSCC) | Discover Oncology
Description:
The potential implications of Coronavirus disease-2019 (COVID-19) on oral squamous cell carcinoma (OSCC) development, chemo-resistance, tumor recurrence, and patient outcomes are explored, emphasizing the urgent need for tailored therapeutic strategies to mitigate these risks. The role of hypoxia-inducible factor 1-alpha (HIF-1α) in OSCC studies has highlighted HIF-1α as a crucial prognostic marker in OSCC, with implications for disease prognosis and patient survival. Its overexpression has been linked to aggressive subtypes in early OSCC stages, indicating its significance as an early biomarker for disease progression. Moreover, dysplastic lesions with heightened HIF-1α expression exhibit a greater propensity for malignant transformation, underscoring its role in early oral carcinogenesis. Cancer patients, including those with OSCC, face an elevated risk of severe COVID-19 complications, which may further impact cancer progression and treatment outcomes. Understanding the interplay between COVID-19 infection, HIF-1α activation, and OSCC pathogenesis is crucial for enhancing clinical management strategies. So, insights from this review shed light on the significance of HIF-1α in OSCC tumorigenesis, metastasis formation, and patient prognosis. The review underscores the need for further research to elucidate the precise mechanisms through which HIF-1α modulates cancer progression and chemo-resistance in the context of COVID-19 infection. Such knowledge is essential for developing targeted therapeutic interventions to improve outcomes for OSCC patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Science
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Keywords {🔍}

pubmed, hifα, article, google, scholar, oscc, cell, cancer, tumor, cas, central, hypoxia, cells, oral, covid, carcinoma, squamous, autophagy, progression, expression, sarscov, factor, chemoresistance, patients, treatment, signaling, potential, development, role, glut, research, glycolysis, therapy, therapeutic, infection, glucose, pathways, target, prognostic, growth, prognosis, chemotherapy, protein, hypoxic, hif, metabolism, hypoxiainducible, receptor, targeting, study,

Topics {✒️}

basic-helix-loop-helix-pas heterodimer regulated pi3k/akt/mtor/hif-1α signaling cascade sars-cov-2-induced immune-inflammatory reactions explore hif-1α-targeted interventions nf-κb/ikba/p65 signaling virgilio-da-silva jv ampk/pox/ros signaling pathway hif-α activationsars-cov-2 binding hif-1α/glycolysis-dependent axis akt/mtor/hif-1 signaling identified hif-1α-dependent metabolic reprogramming hypoxia-inducible factor 1-alpha hypoxia-inducible factor-1 alpha article download pdf sars-cov-2-infected hamsters pi3k-akt-gsk-3β anti-sars-cov-2 agent hif-1α regulates immunological routine dental check-ups genome-scale metabolic modelling raf/ras/mek/erk1 tumour immune escape janus kinase/signal transducers hypoxia/hif-1α/vegf pathway hypoxia-inducible factor-1α hypoxia-inducible factor 1α neck squamous carcinoma pi3k/akt/mtor pathway [27] targeting oxygen-related nanomachineries pi3k/akt/mtor pathways [127] hif-1α subsequently boosted sars-cov-2 infected cells sars-cov-2-induced hypoxia hif-1a-mediated destabilization squamous cell carcinoma hif-1α signaling pathway enhancing sars-cov-2 infection oxygen-dependent degradation domains inhibit hif-1α breakdown sars-cov-2 infection initiates hypoxia-driven immune escape sars-cov-2 spike protein hypoxia-inducible factors 1α hif-1α-regulated genes huh7 cell lines eliciting pro-inflammatory responses stronger anti-tumor impact long-term neurological complications increased hif-1α signaling hif-1α regulation makes

Questions {❓}

A cellular and molecular biology-based update for ivermectin against COVID-19: is it effective or non-effective?
Letter to the editor: is HIF-1α a viable prognostic indicator in OSCC?
What is the impact of COVID-19 on head and neck squamous cell carcinoma patients?
Is HIF-1α a viable prognostic indicator in OSCC?

Schema {🗺️}

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         description:The potential implications of Coronavirus disease-2019 (COVID-19) on oral squamous cell carcinoma (OSCC) development, chemo-resistance, tumor recurrence, and patient outcomes are explored, emphasizing the urgent need for tailored therapeutic strategies to mitigate these risks. The role of hypoxia-inducible factor 1-alpha (HIF-1α) in OSCC studies has highlighted HIF-1α as a crucial prognostic marker in OSCC, with implications for disease prognosis and patient survival. Its overexpression has been linked to aggressive subtypes in early OSCC stages, indicating its significance as an early biomarker for disease progression. Moreover, dysplastic lesions with heightened HIF-1α expression exhibit a greater propensity for malignant transformation, underscoring its role in early oral carcinogenesis. Cancer patients, including those with OSCC, face an elevated risk of severe COVID-19 complications, which may further impact cancer progression and treatment outcomes. Understanding the interplay between COVID-19 infection, HIF-1α activation, and OSCC pathogenesis is crucial for enhancing clinical management strategies. So, insights from this review shed light on the significance of HIF-1α in OSCC tumorigenesis, metastasis formation, and patient prognosis. The review underscores the need for further research to elucidate the precise mechanisms through which HIF-1α modulates cancer progression and chemo-resistance in the context of COVID-19 infection. Such knowledge is essential for developing targeted therapeutic interventions to improve outcomes for OSCC patients.
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      headline:Hypoxia signaling in cancer: HIF-1α stimulated by COVID-19 can lead to cancer progression and chemo-resistance in oral squamous cell carcinoma (OSCC)
      description:The potential implications of Coronavirus disease-2019 (COVID-19) on oral squamous cell carcinoma (OSCC) development, chemo-resistance, tumor recurrence, and patient outcomes are explored, emphasizing the urgent need for tailored therapeutic strategies to mitigate these risks. The role of hypoxia-inducible factor 1-alpha (HIF-1α) in OSCC studies has highlighted HIF-1α as a crucial prognostic marker in OSCC, with implications for disease prognosis and patient survival. Its overexpression has been linked to aggressive subtypes in early OSCC stages, indicating its significance as an early biomarker for disease progression. Moreover, dysplastic lesions with heightened HIF-1α expression exhibit a greater propensity for malignant transformation, underscoring its role in early oral carcinogenesis. Cancer patients, including those with OSCC, face an elevated risk of severe COVID-19 complications, which may further impact cancer progression and treatment outcomes. Understanding the interplay between COVID-19 infection, HIF-1α activation, and OSCC pathogenesis is crucial for enhancing clinical management strategies. So, insights from this review shed light on the significance of HIF-1α in OSCC tumorigenesis, metastasis formation, and patient prognosis. The review underscores the need for further research to elucidate the precise mechanisms through which HIF-1α modulates cancer progression and chemo-resistance in the context of COVID-19 infection. Such knowledge is essential for developing targeted therapeutic interventions to improve outcomes for OSCC patients.
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         Surgical Oncology
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