We are analyzing https://link.springer.com/article/10.1007/s12551-025-01276-z.

Title:
Biophysics of SARS-CoV-2 spike protein’s receptor-binding domain interaction with ACE2 and neutralizing antibodies: from computation to functional insights | Biophysical Reviews
Description:
The spike protein encoded by the SARS-CoV-2 has become one of the most studied macromolecules in recent years due to its central role in COVID-19 pathogenesis. The spike protein’s receptor-binding domain (RBD) directly interacts with the host-encoded receptor protein, ACE2. This review critically examines computational insights into RBD’s interaction with ACE2 and with therapeutic antibodies designed to interfere with this interaction. We begin by summarizing insights from early computational studies on pre-pandemic SARS-CoV-1 RBD interactions and how these early studies shaped the understanding of SARS-CoV-2. Next, we highlight key theoretical contributions that revealed the molecular mechanisms behind the binding affinity of SARS-CoV-2 RBD against ACE2, and the structural changes that have enhanced the infectivity of emerging variants. Special attention is given to the “RBD charge rule”, a predictive framework for determining variant infectivity based on the electrostatic properties of the RBD. Towards applying the computational insights to therapy, we discuss a multiscale computational protocol for optimizing monoclonal antibodies to improve binding affinity across multiple spike protein variants, including representatives from the Omicron family. Finally, we explore how these insights can inform the development of future vaccines and therapeutic interventions for combating future coronavirus diseases.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

retrieved, sarscov, protein, publisher, spike, ace, chem, nature, binding, receptor, article, coronavirus, human, httpsdoiorgs, publishing, httpsdoiorg, antibody, pubmed, molecular, zhang, rbd, sci, computational, variants, wang, antibodies, group, silva, affinity, design, phys, american, httpsdoiorgacsjpcbc, domain, barroso, interactions, society, receptorbinding, covid, science, google, scholar, httpswwwnaturecomarticless, cell, chemical, dynamics, structure, cas, mol, rev,

Topics {✒️}

org/social-issues-migration-health/healthat-a-glance-latin-america org/en/content/articlelanding/2018/cs/c8cs00523k org/content/article/scienceadviserfinding-hope-long gov/pmc/articles/pmc7755986/ xie gov/articles/pmc2992757/ bayarri-olmos /science/article/pii/s0092867422011199 tai /science/article/pii/s0021925820751112 wrapp gov/pmc/articles/pmc8266303/ dai gov/pmc/articles/pmc9693616/ geng /science/article/pii/007961079290006r oecd /science/article/pii/s1359644622002823 vuitika gov/pmc/articles/pmc2242497/ convertino sars-cov-2 receptor-binding domain gov/pmc/articles/pmc10183628/ wu /science/article/pii/s009286742030338x wang /science/article/pii/s1476927107000278 zhou month download article/chapter sars-cov-1/cov-2 spike proteins cn/en/article/doi/https /retrieve/pii/s0021925821003148 begum /retrieve/pii/s0006291x2401115x bò /retrieve/pii/s0168165605007492 gangavarapu /retrieve/pii/s0006291x03026792 prachar /retrieve/pii/s1532046414002330 sormanni /retrieve/pii/s0165614704000975 vabret /retrieve/pii/s1074761320301837 verma sars-cov-2 spike glycoprotein host species-specific receptors gov/articles/pmc9115176/ schymkowitz aleea grigore ghica-voda sars-cov-2 spike protein sars-cov-2 spike protein angiotensin-converting enzyme 2 sars-cov-2 omicron subvariants antibody complementarity-determining regions high-density repetitive manner receptor-binding domain interaction molecular dynamics-based approach /retrieve/pii/s0092867420302622 wang cryo-electron microscopy structures vlp-based covid-19 vaccines sars-cov-2 omicron xbb sars-cov-2 spike proteins sars-cov-2 spike rbd omicron sars-cov-2 rbd constant-ph simulation methods high-throughput molecular simulations host-encoded receptor protein sars-cov2—molecular design updates including sabdab-nano

Questions {❓}

Batlle D, Soler MJ, Ye M (2010) ACE2 and Diabetes: ACE of ACEs?
Nguyen HL, Lan PD, Thai NQ, Nissley DA, O’Brien EP, Li MS (2020) Does SARS-CoV-2 Bind to Human ACE2 More Strongly Than Does SARS-CoV?
Spinello A, Saltalamacchia A, Magistrato A (2020) Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity?
De Andrade J, Gonçalves PFB, Netz PA (2021) Why Does the Novel Coronavirus Spike Protein Interact so Strongly with the Human ACE2?
Org/plosone/article?
Org/plospathogens/article?

Schema {🗺️}

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