We are analyzing https://link.springer.com/article/10.1007/s12325-021-01914-4.

Title:
Sedation Effects Produced by a Ciprofol Initial Infusion or Bolus Dose Followed by Continuous Maintenance Infusion in Healthy Subjects: A Phase 1 Trial | Advances in Therapy
Description:
The effects of continuous infusions of ciprofol on its pharmacodynamic and pharmacokinetic properties and safety profiles in healthy Chinese subjects were evaluated. In this open-label, randomized, two-way cross-over study, subjects received initial doses of continuous ciprofol/propofol as an infusion for 30 min in part 1 (n = 8) and a bolus dose in part 2 (n = 8) followed by maintenance infusions for a total of 4 h in part 1 and 12 h in part 2. Each subject participated in both parts with a washout time of at least 40 h. The safety and tolerability parameters of ciprofol were similar to those of propofol, and all treatment-emergent adverse events were mild. The incidences of injection pain and respiratory depression in subjects given ciprofol were lower than those receiving propofol. The pharmacokinetic parameters Cmax, tmax, t1/2, λz and MRT for ciprofol and propofol were similar, while CL, Vd and Vss were statistically significantly different. Pharmacodynamic parameters including the Richmond Agitation Sedation Scale and bispectral index profiles of ciprofol were similar to those of propofol. Ciprofol has potential for clinical application for continuous intravenous infusion to maintain sedation for 12 h with the same safety, tolerability and efficacy as propofol.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Insurance

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

propofol, ciprofol, study, subjects, part, sedation, infusion, min, dose, article, pubmed, google, scholar, time, cas, maintenance, pain, injection, rass, continuous, safety, concentration, administration, plasma, parameters, clinical, drug, mgkgh, similar, studies, fig, end, initial, average, received, table, httpsdoiorg, data, phase, duration, china, healthy, lower, anesthesia, blood, liu, bolus, trial, properties, patients,

Topics {✒️}

treatment-emergent adverse events randomized placebo-controlled trial larger inter-individual variability article download pdf comparative canine pharmacokinetics-pharmacodynamics γ-aminobutyric acid type randomized split-body trial terminal elimination half-life open access fees steady-state plasma concentration lower inter-subject variability cyclodextrin-enabled propofol solution integrated pharmacokinetic-pharmacodynamic model steady-state distribution volume common drug-related teae target-controlled system plasma concentration-time curve propofol-positive controlled study inter-individual variability lc/ms–ms heart rate-time curve jia miao declare inter-subject variability long-term continuous infusion clinical trials center full access previous clinical trials privacy choices/manage cookies ciprofol dose/plasma exposure individual concentration-time data steady-state concentration treatment-emergent aes numerous clinical maneuvers plasma concentration-time profiles developed drug-related hypotension long-term propofol infusion vital signs teaes reach statistical significance dental care body mass index systolic blood pressure pharmacodynamic parameters including laboratory tests individual pd parameters pd parameters showed haisco pharmaceutical group meddra preferred term plasma sample collections respiratory-related teaes anesthesia-induced injection pain

Questions {❓}

Sympathoinhibition or direct vascular relaxation?
What was learned from the study?
Why carry out this study?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Sedation Effects Produced by a Ciprofol Initial Infusion or Bolus Dose Followed by Continuous Maintenance Infusion in Healthy Subjects: A Phase 1 Trial
         description:The effects of continuous infusions of ciprofol on its pharmacodynamic and pharmacokinetic properties and safety profiles in healthy Chinese subjects were evaluated. In this open-label, randomized, two-way cross-over study, subjects received initial doses of continuous ciprofol/propofol as an infusion for 30 min in part 1 (n = 8) and a bolus dose in part 2 (n = 8) followed by maintenance infusions for a total of 4 h in part 1 and 12 h in part 2. Each subject participated in both parts with a washout time of at least 40 h. The safety and tolerability parameters of ciprofol were similar to those of propofol, and all treatment-emergent adverse events were mild. The incidences of injection pain and respiratory depression in subjects given ciprofol were lower than those receiving propofol. The pharmacokinetic parameters Cmax, tmax, t1/2, λz and MRT for ciprofol and propofol were similar, while CL, Vd and Vss were statistically significantly different. Pharmacodynamic parameters including the Richmond Agitation Sedation Scale and bispectral index profiles of ciprofol were similar to those of propofol. Ciprofol has potential for clinical application for continuous intravenous infusion to maintain sedation for 12 h with the same safety, tolerability and efficacy as propofol.
         datePublished:2021-09-24T00:00:00Z
         dateModified:2021-09-24T00:00:00Z
         pageStart:5484
         pageEnd:5500
         license:http://creativecommons.org/licenses/by-nc/4.0/
         sameAs:https://doi.org/10.1007/s12325-021-01914-4
         keywords:
            Ciprofol
            Sedation
            Safety
            Pharmacokinetics
            Pharmacodynamics
            Propofol
            Internal Medicine
            Oncology
            Cardiology
            Rheumatology
            Endocrinology
            Pharmacology/Toxicology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12325-021-01914-4/MediaObjects/12325_2021_1914_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12325-021-01914-4/MediaObjects/12325_2021_1914_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12325-021-01914-4/MediaObjects/12325_2021_1914_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12325-021-01914-4/MediaObjects/12325_2021_1914_Fig4_HTML.png
         isPartOf:
            name:Advances in Therapy
            issn:
               1865-8652
               0741-238X
            volumeNumber:38
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Healthcare
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Chao Hu
               affiliation:
                     name:Sichuan University
                     address:
                        name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaofeng Ou
               affiliation:
                     name:Sichuan University
                     address:
                        name:Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yi Teng
               affiliation:
                     name:Sichuan University
                     address:
                        name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shiqing Shu
               affiliation:
                     name:Sichuan University
                     address:
                        name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ying Wang
               affiliation:
                     name:Sichuan University
                     address:
                        name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaohong Zhu
               affiliation:
                     name:Sichuan University
                     address:
                        name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yan Kang
               affiliation:
                     name:Sichuan University
                     address:
                        name:Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jia Miao
               affiliation:
                     name:Sichuan University
                     address:
                        name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Sedation Effects Produced by a Ciprofol Initial Infusion or Bolus Dose Followed by Continuous Maintenance Infusion in Healthy Subjects: A Phase 1 Trial
      description:The effects of continuous infusions of ciprofol on its pharmacodynamic and pharmacokinetic properties and safety profiles in healthy Chinese subjects were evaluated. In this open-label, randomized, two-way cross-over study, subjects received initial doses of continuous ciprofol/propofol as an infusion for 30 min in part 1 (n = 8) and a bolus dose in part 2 (n = 8) followed by maintenance infusions for a total of 4 h in part 1 and 12 h in part 2. Each subject participated in both parts with a washout time of at least 40 h. The safety and tolerability parameters of ciprofol were similar to those of propofol, and all treatment-emergent adverse events were mild. The incidences of injection pain and respiratory depression in subjects given ciprofol were lower than those receiving propofol. The pharmacokinetic parameters Cmax, tmax, t1/2, λz and MRT for ciprofol and propofol were similar, while CL, Vd and Vss were statistically significantly different. Pharmacodynamic parameters including the Richmond Agitation Sedation Scale and bispectral index profiles of ciprofol were similar to those of propofol. Ciprofol has potential for clinical application for continuous intravenous infusion to maintain sedation for 12 h with the same safety, tolerability and efficacy as propofol.
      datePublished:2021-09-24T00:00:00Z
      dateModified:2021-09-24T00:00:00Z
      pageStart:5484
      pageEnd:5500
      license:http://creativecommons.org/licenses/by-nc/4.0/
      sameAs:https://doi.org/10.1007/s12325-021-01914-4
      keywords:
         Ciprofol
         Sedation
         Safety
         Pharmacokinetics
         Pharmacodynamics
         Propofol
         Internal Medicine
         Oncology
         Cardiology
         Rheumatology
         Endocrinology
         Pharmacology/Toxicology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12325-021-01914-4/MediaObjects/12325_2021_1914_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12325-021-01914-4/MediaObjects/12325_2021_1914_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12325-021-01914-4/MediaObjects/12325_2021_1914_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12325-021-01914-4/MediaObjects/12325_2021_1914_Fig4_HTML.png
      isPartOf:
         name:Advances in Therapy
         issn:
            1865-8652
            0741-238X
         volumeNumber:38
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Healthcare
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Chao Hu
            affiliation:
                  name:Sichuan University
                  address:
                     name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaofeng Ou
            affiliation:
                  name:Sichuan University
                  address:
                     name:Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yi Teng
            affiliation:
                  name:Sichuan University
                  address:
                     name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shiqing Shu
            affiliation:
                  name:Sichuan University
                  address:
                     name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ying Wang
            affiliation:
                  name:Sichuan University
                  address:
                     name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaohong Zhu
            affiliation:
                  name:Sichuan University
                  address:
                     name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yan Kang
            affiliation:
                  name:Sichuan University
                  address:
                     name:Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jia Miao
            affiliation:
                  name:Sichuan University
                  address:
                     name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Advances in Therapy
      issn:
         1865-8652
         0741-238X
      volumeNumber:38
Organization:
      name:Springer Healthcare
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Sichuan University
      address:
         name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
         type:PostalAddress
      name:Sichuan University
      address:
         name:Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China
         type:PostalAddress
      name:Sichuan University
      address:
         name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China
         type:PostalAddress
      name:Sichuan University
      address:
         name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
         type:PostalAddress
      name:Sichuan University
      address:
         name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
         type:PostalAddress
      name:Sichuan University
      address:
         name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
         type:PostalAddress
      name:Sichuan University
      address:
         name:Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China
         type:PostalAddress
      name:Sichuan University
      address:
         name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Chao Hu
      affiliation:
            name:Sichuan University
            address:
               name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
               type:PostalAddress
            type:Organization
      name:Xiaofeng Ou
      affiliation:
            name:Sichuan University
            address:
               name:Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China
               type:PostalAddress
            type:Organization
      name:Yi Teng
      affiliation:
            name:Sichuan University
            address:
               name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China
               type:PostalAddress
            type:Organization
      name:Shiqing Shu
      affiliation:
            name:Sichuan University
            address:
               name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
               type:PostalAddress
            type:Organization
      name:Ying Wang
      affiliation:
            name:Sichuan University
            address:
               name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
               type:PostalAddress
            type:Organization
      name:Xiaohong Zhu
      affiliation:
            name:Sichuan University
            address:
               name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
               type:PostalAddress
            type:Organization
      name:Yan Kang
      affiliation:
            name:Sichuan University
            address:
               name:Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jia Miao
      affiliation:
            name:Sichuan University
            address:
               name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China
      name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
      name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
      name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China
      name:Clinical Trials Center, West China Hospital, Sichuan University, Chengdu, China

External Links {🔗}(168)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.14s.

LINK . SPRINGER . COM {}