We are analyzing https://link.springer.com/article/10.1007/s12325-021-01690-1.

Title:
Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management | Advances in Therapy
Description:
Precision medicine defines the attempt to identify the most effective approaches for specific subsets of patients based on their genetic background, clinical features, and environmental factors. Nonalcoholic fatty liver disease (NAFLD) encompasses the alcohol-like spectrum of liver disorders (steatosis, steatohepatitis with/without fibrosis, and cirrhosis and hepatocellular carcinoma) in the nonalcoholic patient. Recently, disease renaming to MAFLD [metabolic (dysfunction)-associated fatty liver disease] and positive criteria for diagnosis have been proposed. This review article is specifically devoted to envisaging some clues that may be useful to implementing a precision medicine-oriented approach in research and clinical practice. To this end, we focus on how sex and reproductive status, genetics, intestinal microbiota diversity, endocrine and metabolic status, as well as physical activity may interact in determining NAFLD/MAFLD heterogeneity. All these factors should be considered in the individual patient with the aim of implementing an individualized therapeutic plan. The impact of considering NAFLD heterogeneity on the development of targeted therapies for NAFLD subgroups is also extensively discussed.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Science
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

pubmed, liver, nafld, article, disease, google, scholar, nonalcoholic, fatty, patients, cas, risk, fibrosis, medicine, central, hepatol, precision, clinical, exercise, diabetes, gastroenterol, management, data, metabolic, sex, nash, studies, cardiovascular, review, lonardo, patient, treatment, microbiota, based, diagnosis, genetic, approach, hepatic, study, clin, therapy, steatohepatitis, therapeutic, diet, status, gut, weight, approaches, factors, physical,

Topics {✒️}

long-term safety profile final report summary—meta-predict metabolomic profiles antiatherogenic lipid profile author information authors atherogenic lipoprotein profile low-carbohydrate high-fat diets author correspondence original author higuera-de-la-tijera microbiota-centered view article download pdf eu/project/id/277936/reporting alcoholic fatty-liver disease amedeo lonardo view digital features improves cardio-respiratory fitness frankly altered gluco-tolerance environmental profile hepatitis c-related fibrosis vibration-controlled transient elastography moderate-intensity aerobic exercise clear-cut data suggesting data supporting cost-effectiveness metabolic syndrome-related nafld genome-wide association studies alcohol-related liver disease pontificia universidad católica alvares-da-silva mr growth hormone axis evolving view nash-related cirrhosis treated germ-free mice exhibit multi-centre intervention study multi-national cohort study dose–response relationship exists blood-based biomarker panel arab jp high-intensity interval training vilar-gomez middle-aged swedish men alcoholic fatty liver gut microbiome-targeted therapies thyroid–liver axis tecnología de chile low-carbohydrate diets fatty liver disease] fatty liver disease fatty liver disease nonalcoholic steatohepatitis-related

Questions {❓}

A round trip from nonalcoholic fatty liver disease to diabetes: molecular targets to the rescue?
Abnormalities in the growth hormone axis and risk of nonalcoholic steatohepatitis: active player or innocent bystander?
Do metabolic syndrome-related NAFLD and PNPLA3-related NAFLD exert a variable impact on the risk of early carotid atherosclerosis?
Does clinical methodology yet exist?
Does nonalcoholic fatty liver disease cause cardiovascular disease?
Evidence that non-alcoholic fatty liver disease and polycystic ovary syndrome are associated by necessity rather than chance: a novel hepato-ovarian axis?
Hypothyroidism and nonalcoholic fatty liver disease - a chance association?
Non-alcoholic fatty liver disease and hypertension: coprevalent or correlated?
Nonalcoholic fatty liver disease: does sex matter?
Pathogenesis of hypothyroidism-induced NAFLD: Evidence for a distinct disease entity?
Renaming NAFLD to MAFLD: could the LDE system assist in this transition?
Thyroid hormones and thyromimetics: a new approach to nonalcoholic steatohepatitis?
What’s in a name?
Why do so many NASH trials fail?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management
         description:Precision medicine defines the attempt to identify the most effective approaches for specific subsets of patients based on their genetic background, clinical features, and environmental factors. Nonalcoholic fatty liver disease (NAFLD) encompasses the alcohol-like spectrum of liver disorders (steatosis, steatohepatitis with/without fibrosis, and cirrhosis and hepatocellular carcinoma) in the nonalcoholic patient. Recently, disease renaming to MAFLD [metabolic (dysfunction)-associated fatty liver disease] and positive criteria for diagnosis have been proposed. This review article is specifically devoted to envisaging some clues that may be useful to implementing a precision medicine-oriented approach in research and clinical practice. To this end, we focus on how sex and reproductive status, genetics, intestinal microbiota diversity, endocrine and metabolic status, as well as physical activity may interact in determining NAFLD/MAFLD heterogeneity. All these factors should be considered in the individual patient with the aim of implementing an individualized therapeutic plan. The impact of considering NAFLD heterogeneity on the development of targeted therapies for NAFLD subgroups is also extensively discussed.
         datePublished:2021-04-07T00:00:00Z
         dateModified:2021-04-07T00:00:00Z
         pageStart:2130
         pageEnd:2158
         license:http://creativecommons.org/licenses/by-nc/4.0/
         sameAs:https://doi.org/10.1007/s12325-021-01690-1
         keywords:
            Cirrhosis
            Fibrosis
            Metabolic syndrome
            NAFLD
            NASH
            Nonalcoholic fatty liver disease
            Nonalcoholic steatohepatitis
            Steatosis
            Internal Medicine
            Oncology
            Cardiology
            Rheumatology
            Endocrinology
            Pharmacology/Toxicology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12325-021-01690-1/MediaObjects/12325_2021_1690_Fig1_HTML.png
         isPartOf:
            name:Advances in Therapy
            issn:
               1865-8652
               0741-238X
            volumeNumber:38
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Healthcare
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Amedeo Lonardo
               url:http://orcid.org/0000-0001-9886-0698
               affiliation:
                     name:Azienda Ospedaliero-Universitaria
                     address:
                        name:Department of Internal Medicine, Azienda Ospedaliero-Universitaria, Modena, Italy
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Juan Pablo Arab
               url:https://orcid.org/0000-0002-8561-396X
               affiliation:
                     name:Escuela de Medicina, Pontificia Universidad Católica de Chile
                     address:
                        name:Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
                        type:PostalAddress
                     type:Organization
                     name:Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
                     address:
                        name:Departamento de Biología Celular y Molecular, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marco Arrese
               url:https://orcid.org/0000-0002-0499-4191
               affiliation:
                     name:Escuela de Medicina, Pontificia Universidad Católica de Chile
                     address:
                        name:Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
                        type:PostalAddress
                     type:Organization
                     name:Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
                     address:
                        name:Departamento de Biología Celular y Molecular, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management
      description:Precision medicine defines the attempt to identify the most effective approaches for specific subsets of patients based on their genetic background, clinical features, and environmental factors. Nonalcoholic fatty liver disease (NAFLD) encompasses the alcohol-like spectrum of liver disorders (steatosis, steatohepatitis with/without fibrosis, and cirrhosis and hepatocellular carcinoma) in the nonalcoholic patient. Recently, disease renaming to MAFLD [metabolic (dysfunction)-associated fatty liver disease] and positive criteria for diagnosis have been proposed. This review article is specifically devoted to envisaging some clues that may be useful to implementing a precision medicine-oriented approach in research and clinical practice. To this end, we focus on how sex and reproductive status, genetics, intestinal microbiota diversity, endocrine and metabolic status, as well as physical activity may interact in determining NAFLD/MAFLD heterogeneity. All these factors should be considered in the individual patient with the aim of implementing an individualized therapeutic plan. The impact of considering NAFLD heterogeneity on the development of targeted therapies for NAFLD subgroups is also extensively discussed.
      datePublished:2021-04-07T00:00:00Z
      dateModified:2021-04-07T00:00:00Z
      pageStart:2130
      pageEnd:2158
      license:http://creativecommons.org/licenses/by-nc/4.0/
      sameAs:https://doi.org/10.1007/s12325-021-01690-1
      keywords:
         Cirrhosis
         Fibrosis
         Metabolic syndrome
         NAFLD
         NASH
         Nonalcoholic fatty liver disease
         Nonalcoholic steatohepatitis
         Steatosis
         Internal Medicine
         Oncology
         Cardiology
         Rheumatology
         Endocrinology
         Pharmacology/Toxicology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12325-021-01690-1/MediaObjects/12325_2021_1690_Fig1_HTML.png
      isPartOf:
         name:Advances in Therapy
         issn:
            1865-8652
            0741-238X
         volumeNumber:38
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Healthcare
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Amedeo Lonardo
            url:http://orcid.org/0000-0001-9886-0698
            affiliation:
                  name:Azienda Ospedaliero-Universitaria
                  address:
                     name:Department of Internal Medicine, Azienda Ospedaliero-Universitaria, Modena, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Juan Pablo Arab
            url:https://orcid.org/0000-0002-8561-396X
            affiliation:
                  name:Escuela de Medicina, Pontificia Universidad Católica de Chile
                  address:
                     name:Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
                     type:PostalAddress
                  type:Organization
                  name:Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
                  address:
                     name:Departamento de Biología Celular y Molecular, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marco Arrese
            url:https://orcid.org/0000-0002-0499-4191
            affiliation:
                  name:Escuela de Medicina, Pontificia Universidad Católica de Chile
                  address:
                     name:Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
                     type:PostalAddress
                  type:Organization
                  name:Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
                  address:
                     name:Departamento de Biología Celular y Molecular, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Advances in Therapy
      issn:
         1865-8652
         0741-238X
      volumeNumber:38
Organization:
      name:Springer Healthcare
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Azienda Ospedaliero-Universitaria
      address:
         name:Department of Internal Medicine, Azienda Ospedaliero-Universitaria, Modena, Italy
         type:PostalAddress
      name:Escuela de Medicina, Pontificia Universidad Católica de Chile
      address:
         name:Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
         type:PostalAddress
      name:Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
      address:
         name:Departamento de Biología Celular y Molecular, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
         type:PostalAddress
      name:Escuela de Medicina, Pontificia Universidad Católica de Chile
      address:
         name:Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
         type:PostalAddress
      name:Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
      address:
         name:Departamento de Biología Celular y Molecular, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Amedeo Lonardo
      url:http://orcid.org/0000-0001-9886-0698
      affiliation:
            name:Azienda Ospedaliero-Universitaria
            address:
               name:Department of Internal Medicine, Azienda Ospedaliero-Universitaria, Modena, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Juan Pablo Arab
      url:https://orcid.org/0000-0002-8561-396X
      affiliation:
            name:Escuela de Medicina, Pontificia Universidad Católica de Chile
            address:
               name:Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
               type:PostalAddress
            type:Organization
            name:Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
            address:
               name:Departamento de Biología Celular y Molecular, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
               type:PostalAddress
            type:Organization
      name:Marco Arrese
      url:https://orcid.org/0000-0002-0499-4191
      affiliation:
            name:Escuela de Medicina, Pontificia Universidad Católica de Chile
            address:
               name:Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
               type:PostalAddress
            type:Organization
            name:Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
            address:
               name:Departamento de Biología Celular y Molecular, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Internal Medicine, Azienda Ospedaliero-Universitaria, Modena, Italy
      name:Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
      name:Departamento de Biología Celular y Molecular, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
      name:Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
      name:Departamento de Biología Celular y Molecular, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

External Links {🔗}(536)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.26s.

LINK . SPRINGER . COM {}