We are analyzing https://link.springer.com/article/10.1007/s12291-023-01166-9.

Title:
Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy | Indian Journal of Clinical Biochemistry
Description:
Cancer treatment era has been revolutionized by the novel therapeutic methods such as immunotherapy in recent years. Immunotherapy-based approaches are considered effective and reliable methods that has brought hope to eradicate certain cancers. Nonetheless, there are some issues, considered as critical obstacles in successful cancer immunotherapy. Such issues are attributed to the ability of the tumor cells in providing a tolerant microenvironment that impairs the immune responses, and help the cancer cells evade the immunogenic cell death. It has been suggested that the re-activation and maintenance of effector immune cells may become possible by metabolic reprogramming. Several signaling pathways have been noticed with the possibility of metabolic reprogramming of tumor-specific T cells, to overcome the metabolic restrictions in the tumor microenvironment; and among them, AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptors (PPAR) have been investigated the most as the main energy sensors and regulators of mitochondrial biogenesis. The synergic effects of AMPK activators and/or PPAR agonists in cancer immunotherapy have been reported. In this review, we compare the roles of AMPK activators and PPAR agonists, and the efficacy of their combination in metabolic reprogramming of cytotoxic T cells in favoring cancer immunotherapy.
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, cell, cancer, cells, metabolic, metabolism, immunotherapy, ampk, reprogramming, tumor, immunol, nat, biol, acid, kinase, zhang, fatty, sci, metformin, activation, pathway, university, iraq, signaling, rev, med, wang, college, function, targeting, ppar, microenvironment, protein, mitochondrial, therapy, ampactivated, peroxisome, proliferatoractivated, energy, agonists, mol, receptor, res, front, human,

Topics {✒️}

lpe-pparγ-nf-κb-ccl5 pathway canonical wnt/β-catenin pathway month download article/chapter induce prodh/pox-dependent apoptosis gastrointestinal microbiota-ampk-mtor axis ampk–mir-107–eomes–pd-1 pathway fatty acid β-oxidation immune-mediated anti-tumor effects pparγ/pgc-1α-fndc5 pathway peroxisome proliferator-activated receptors amp-activated protein kinase enhanced anti-tumor response pml–ppar-δ pathway triple-negative breast cancer lipid-activated nuclear receptors d-mannose facilitates immunotherapy facilitates anti–pd-1 therapy promotes ligand-independent activation fatty acid oxidation article indian journal nonsteroidal anti-inflammatory drugs arf1-mediated lipid metabolism hassan hadi al-kazzaz activation-induced metabolic reprogramming cell-dependent antitumor activity abduldaheem turki jalil pi3k/akt/mtor signaling full article pdf pparγ/ampk signaling pathway diab/metab res rev ampk/mtor signaling pathway al-mustaqbal university college al-turath university college fatty acid metabolism kinase mtor regulates safaa halool mohammed privacy choices/manage cookies cell stem cell nsaid-induced apoptosis limited nutrient availability pd-1 promotes accumulation delgoffe gm garcia-roves pm optimize cancer immunotherapy immunotherapy-based approaches mtor-mediated inductions lactate regulates metabolic article jalil cell metabolic adaptation biol targets therapy

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         headline:Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy
         description:Cancer treatment era has been revolutionized by the novel therapeutic methods such as immunotherapy in recent years. Immunotherapy-based approaches are considered effective and reliable methods that has brought hope to eradicate certain cancers. Nonetheless, there are some issues, considered as critical obstacles in successful cancer immunotherapy. Such issues are attributed to the ability of the tumor cells in providing a tolerant microenvironment that impairs the immune responses, and help the cancer cells evade the immunogenic cell death. It has been suggested that the re-activation and maintenance of effector immune cells may become possible by metabolic reprogramming. Several signaling pathways have been noticed with the possibility of metabolic reprogramming of tumor-specific T cells, to overcome the metabolic restrictions in the tumor microenvironment; and among them, AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptors (PPAR) have been investigated the most as the main energy sensors and regulators of mitochondrial biogenesis. The synergic effects of AMPK activators and/or PPAR agonists in cancer immunotherapy have been reported. In this review, we compare the roles of AMPK activators and PPAR agonists, and the efficacy of their combination in metabolic reprogramming of cytotoxic T cells in favoring cancer immunotherapy.
         datePublished:2024-01-08T00:00:00Z
         dateModified:2024-01-08T00:00:00Z
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      headline:Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy
      description:Cancer treatment era has been revolutionized by the novel therapeutic methods such as immunotherapy in recent years. Immunotherapy-based approaches are considered effective and reliable methods that has brought hope to eradicate certain cancers. Nonetheless, there are some issues, considered as critical obstacles in successful cancer immunotherapy. Such issues are attributed to the ability of the tumor cells in providing a tolerant microenvironment that impairs the immune responses, and help the cancer cells evade the immunogenic cell death. It has been suggested that the re-activation and maintenance of effector immune cells may become possible by metabolic reprogramming. Several signaling pathways have been noticed with the possibility of metabolic reprogramming of tumor-specific T cells, to overcome the metabolic restrictions in the tumor microenvironment; and among them, AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptors (PPAR) have been investigated the most as the main energy sensors and regulators of mitochondrial biogenesis. The synergic effects of AMPK activators and/or PPAR agonists in cancer immunotherapy have been reported. In this review, we compare the roles of AMPK activators and PPAR agonists, and the efficacy of their combination in metabolic reprogramming of cytotoxic T cells in favoring cancer immunotherapy.
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      dateModified:2024-01-08T00:00:00Z
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         Cancer immunotherapy
         T cell metabolic reprogramming
         PPAR
         Tumor microenvironment
         Biochemistry
         general
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         Pathology
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