We are analyzing https://link.springer.com/article/10.1007/s12274-012-0275-5.

Title:
Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles | Nano Research
Description:
Magnetic nanoparticles have been used as drug delivery vehicles against a number of cancer cells. Most of these theranostic formulations have used solid iron oxide nanoparticles (SIONPs) loaded with chemotherapeutics as nano-carrier formulation for both magnetic resonance imaging (MRI) and cancer therapy. In this study, we applied the dopamine-plus-human serum albumin (HSA) method to modify hollow iron oxide nanoparticles (HIONPs) and encapsuated doxorubicin (DOX) within the hollow porous structure of the nano-carrier. The new delivery system can load more drug than solid iron oxide nanoparticles of the same core size using the same coating strategy. The HIONPs-DOX formulation also has a pH-dependent drug release behaviour. Compared with free DOX, the HIONPs-DOX were more effectively uptaken by the multidrug resistant OVCAR8-ADR cells and consequently more potent in killing drug resistant cancer cells. MRI phantom and cell studies also showed that the HIONPs-DOX can decrease the T 2 MRI signal intensity and can be used as a MRI contrast agent while acting as a drug delivery vehicle. For the first time, the dual application of chemo drug transport and MR imaging using the HIONPs-DOX formulation was achieved against both DOX-sensitive and DOX-resistant cancer cells.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Transportation

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,734,772 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

article, google, scholar, cas, drug, nanoparticles, delivery, cancer, imaging, iron, oxide, wang, doxorubicin, resistance, zhang, nano, hollow, multidrug, magnetic, chen, mri, release, research, anticancer, privacy, cookies, content, xing, sun, liu, cell, mdr, chem, publish, search, resistant, vehicles, november, bhirde, cells, solid, hionpsdox, access, targeted, rev, res, multifunctional, overcome, soc, acs,

Topics {✒️}

month download article/chapter multifunctional yolk-shell nanoparticles liposome-based approaches targeted drug delivery iron oxide nanoparticles iron oxide shell mesoporous silica nano-particles delivery system ph-controlled macromolecule encapsulation multifunctional polymeric nano-conjugates magnetic resonance imaging dox-resistant cancer cells engineered magnetic nanoparticles overcome drug resistance drug delivery vehicles nano-carrier formulation drug delivery vehicle enhanced drug delivery treat breast cancer hollow porous structure targeting multidrug resistance full article pdf targeted delivery nanodrug delivery systems hollow gold nanospheres magnetic nanoparticles privacy choices/manage cookies superparamagnetic magnetite nanoparticles cationic albumin nanoparticles related subjects multi-functional nanocarriers immobilize functional molecules nano-carrier drug delivery gold nanorods conjugated chemo drug transport anticancer polymeric nanomedicines potential mri contrast european economic area loaded human serum albumin bcl-2 family members heat shock proteins polyelectrolyte multilayer nanocapsules p-glycoprotein sirna exceptionally high payload nanoparticle size scope ruijun xing multidrug resistance cancer cell line

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles
         description:Magnetic nanoparticles have been used as drug delivery vehicles against a number of cancer cells. Most of these theranostic formulations have used solid iron oxide nanoparticles (SIONPs) loaded with chemotherapeutics as nano-carrier formulation for both magnetic resonance imaging (MRI) and cancer therapy. In this study, we applied the dopamine-plus-human serum albumin (HSA) method to modify hollow iron oxide nanoparticles (HIONPs) and encapsuated doxorubicin (DOX) within the hollow porous structure of the nano-carrier. The new delivery system can load more drug than solid iron oxide nanoparticles of the same core size using the same coating strategy. The HIONPs-DOX formulation also has a pH-dependent drug release behaviour. Compared with free DOX, the HIONPs-DOX were more effectively uptaken by the multidrug resistant OVCAR8-ADR cells and consequently more potent in killing drug resistant cancer cells. MRI phantom and cell studies also showed that the HIONPs-DOX can decrease the T 2 MRI signal intensity and can be used as a MRI contrast agent while acting as a drug delivery vehicle. For the first time, the dual application of chemo drug transport and MR imaging using the HIONPs-DOX formulation was achieved against both DOX-sensitive and DOX-resistant cancer cells.
         datePublished:2012-11-30T00:00:00Z
         dateModified:2012-11-30T00:00:00Z
         pageStart:1
         pageEnd:9
         sameAs:https://doi.org/10.1007/s12274-012-0275-5
         keywords:
            drug resistance
            hollow nanoparticles
            doxorubicin
            magnetic resonance
            imaging (MRI)
            drug delivery
            Nanotechnology
            Materials Science
            general
            Atomic/Molecular Structure and Spectra
            Condensed Matter Physics
            Biotechnology
            Biomedicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12274-012-0275-5/MediaObjects/12274_2012_275_Fig1_HTML.gif
         isPartOf:
            name:Nano Research
            issn:
               1998-0000
               1998-0124
            volumeNumber:6
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Tsinghua Press
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Ruijun Xing
               affiliation:
                     name:National Institutes of Health (NIH)
                     address:
                        name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                        type:PostalAddress
                     type:Organization
                     name:Peking University
                     address:
                        name:Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ashwinkumar A. Bhirde
               affiliation:
                     name:National Institutes of Health (NIH)
                     address:
                        name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shouju Wang
               affiliation:
                     name:National Institutes of Health (NIH)
                     address:
                        name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaolian Sun
               affiliation:
                     name:National Institutes of Health (NIH)
                     address:
                        name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gang Liu
               affiliation:
                     name:Xiamen University
                     address:
                        name:Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yanglong Hou
               affiliation:
                     name:National Institutes of Health (NIH)
                     address:
                        name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaoyuan Chen
               affiliation:
                     name:National Institutes of Health (NIH)
                     address:
                        name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles
      description:Magnetic nanoparticles have been used as drug delivery vehicles against a number of cancer cells. Most of these theranostic formulations have used solid iron oxide nanoparticles (SIONPs) loaded with chemotherapeutics as nano-carrier formulation for both magnetic resonance imaging (MRI) and cancer therapy. In this study, we applied the dopamine-plus-human serum albumin (HSA) method to modify hollow iron oxide nanoparticles (HIONPs) and encapsuated doxorubicin (DOX) within the hollow porous structure of the nano-carrier. The new delivery system can load more drug than solid iron oxide nanoparticles of the same core size using the same coating strategy. The HIONPs-DOX formulation also has a pH-dependent drug release behaviour. Compared with free DOX, the HIONPs-DOX were more effectively uptaken by the multidrug resistant OVCAR8-ADR cells and consequently more potent in killing drug resistant cancer cells. MRI phantom and cell studies also showed that the HIONPs-DOX can decrease the T 2 MRI signal intensity and can be used as a MRI contrast agent while acting as a drug delivery vehicle. For the first time, the dual application of chemo drug transport and MR imaging using the HIONPs-DOX formulation was achieved against both DOX-sensitive and DOX-resistant cancer cells.
      datePublished:2012-11-30T00:00:00Z
      dateModified:2012-11-30T00:00:00Z
      pageStart:1
      pageEnd:9
      sameAs:https://doi.org/10.1007/s12274-012-0275-5
      keywords:
         drug resistance
         hollow nanoparticles
         doxorubicin
         magnetic resonance
         imaging (MRI)
         drug delivery
         Nanotechnology
         Materials Science
         general
         Atomic/Molecular Structure and Spectra
         Condensed Matter Physics
         Biotechnology
         Biomedicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12274-012-0275-5/MediaObjects/12274_2012_275_Fig1_HTML.gif
      isPartOf:
         name:Nano Research
         issn:
            1998-0000
            1998-0124
         volumeNumber:6
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Tsinghua Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ruijun Xing
            affiliation:
                  name:National Institutes of Health (NIH)
                  address:
                     name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                     type:PostalAddress
                  type:Organization
                  name:Peking University
                  address:
                     name:Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ashwinkumar A. Bhirde
            affiliation:
                  name:National Institutes of Health (NIH)
                  address:
                     name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shouju Wang
            affiliation:
                  name:National Institutes of Health (NIH)
                  address:
                     name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaolian Sun
            affiliation:
                  name:National Institutes of Health (NIH)
                  address:
                     name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gang Liu
            affiliation:
                  name:Xiamen University
                  address:
                     name:Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yanglong Hou
            affiliation:
                  name:National Institutes of Health (NIH)
                  address:
                     name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaoyuan Chen
            affiliation:
                  name:National Institutes of Health (NIH)
                  address:
                     name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nano Research
      issn:
         1998-0000
         1998-0124
      volumeNumber:6
Organization:
      name:Tsinghua Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Institutes of Health (NIH)
      address:
         name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
         type:PostalAddress
      name:Peking University
      address:
         name:Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China
         type:PostalAddress
      name:National Institutes of Health (NIH)
      address:
         name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
         type:PostalAddress
      name:National Institutes of Health (NIH)
      address:
         name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
         type:PostalAddress
      name:National Institutes of Health (NIH)
      address:
         name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
         type:PostalAddress
      name:Xiamen University
      address:
         name:Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
         type:PostalAddress
      name:National Institutes of Health (NIH)
      address:
         name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
         type:PostalAddress
      name:National Institutes of Health (NIH)
      address:
         name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ruijun Xing
      affiliation:
            name:National Institutes of Health (NIH)
            address:
               name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
               type:PostalAddress
            type:Organization
            name:Peking University
            address:
               name:Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China
               type:PostalAddress
            type:Organization
      name:Ashwinkumar A. Bhirde
      affiliation:
            name:National Institutes of Health (NIH)
            address:
               name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Shouju Wang
      affiliation:
            name:National Institutes of Health (NIH)
            address:
               name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Xiaolian Sun
      affiliation:
            name:National Institutes of Health (NIH)
            address:
               name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Gang Liu
      affiliation:
            name:Xiamen University
            address:
               name:Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      name:Yanglong Hou
      affiliation:
            name:National Institutes of Health (NIH)
            address:
               name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Xiaoyuan Chen
      affiliation:
            name:National Institutes of Health (NIH)
            address:
               name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
      name:Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China
      name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
      name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
      name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
      name:Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
      name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
      name:Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(103)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Particles.js
Prism.js

CDN Services {📦}

Crossref

4.46s.

LINK . SPRINGER . COM {}