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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s12272-024-01519-9.

Title:
Exploring NNMT: from metabolic pathways to therapeutic targets | Archives of Pharmacal Research
Description:
Cellular metabolism-related epigenetic modulation plays a pivotal role in the maintenance of cellular homeostasis. Nicotinamide N-methyltransferase (NNMT) serves as a crucial link between cellular metabolism and epigenetics by catalyzing nicotinamide methylation using the universal methyl donor S-adenosyl-L-methionine. This direct connection bridges the methylation-mediated one-carbon metabolism with nicotinamide adenine dinucleotide levels. Numerous studies have revealed tissue-specific differences in NNMT expression and activity, indicating that its varied physiological and pathological roles depend on its distribution. In this review, we provide an overview of the NNMT involvement in various pathological conditions, including cancer, liver disease, obesity, diabetes, brain disease, pulmonary disease, cardiovascular disease, and kidney disease. By synthesizing this information, our article aims to enhance our understanding of the cellular mechanisms underlying NNMT biology related to diverse diseases and lay the molecular groundwork for developing therapeutic strategies for pharmacological interventions.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

pubmed, article, google, scholar, cas, nicotinamide, nmethyltransferase, central, cancer, cell, nnmt, wang, expression, httpsdoiorgs, zhang, chem, med, cells, liu, res, chen, kim, human, sartini, disease, carcinoma, yang, liver, biol, research, gene, parsons, inhibitors, sci, emanuelli, mol, song, huang, zhu, biochem, metabolism, pathway, pozzi, nad, patients, int, campagna, httpsdoiorg, metabolic, methylation,

Topics {✒️}

post-translational modification-dependent activity activating stat3/il1β/pge2 pathway month download article/chapter potential post-translational modification nicotinamide-n-methyltransferase controls behavior nicotinamide-n-methyltransferase mrna expression nicotinamide n-methyltransferase-p53 axis kyu min kim hepatocyte nuclear factor-1β clear-cell renal carcinoma eun jin shin nicotinamide n-methyltransferase enhances nicotinamide n-methyl transferase bacteria-induced fulminant hepatitis immune-related prognostic biomarker nicotinamide n-methyltransferase sustains nicotinamide n-methyltransferase interacts host nicotinamide-n-methyltransferase nicotinamide n-methyltransferase designed rna interference-mediated knockdown urine-based diagnostic test rna-mediated gene silencing propargyl-linked bisubstrate analogues met-interacting protein ranbpm patient-derived assembled organoids high-grade endometrial cancer nicotinamide n-methyltransferase expression wnt/β-catenin pathway ask1-p38 mapk pathway tgf-β1/smad3 pathway nnmt-based urine test adipose differentiation-related protein attenuates nnmt-related resistance activate pi3k/akt signaling genetic nicotinamide n-methyltransferase urinary nicotinamide n-methyltransferase er stress-induced upregulation ros-induced cell apoptosis sh-sy5y neuroblastoma targeted anti-cancer therapy revealed tissue-specific differences diet-induced obesity nicotinamide n-methyltransferase overexpression pi3k/akt/mtor pathway full article pdf small molecule inhibitor enhancing n1-methylnicotinamide bioavailability tae hyun kim educational research group gene rs694539 variant

Schema {🗺️}

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         headline:Exploring NNMT: from metabolic pathways to therapeutic targets
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         datePublished:2024-11-28T00:00:00Z
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      headline:Exploring NNMT: from metabolic pathways to therapeutic targets
      description:Cellular metabolism-related epigenetic modulation plays a pivotal role in the maintenance of cellular homeostasis. Nicotinamide N-methyltransferase (NNMT) serves as a crucial link between cellular metabolism and epigenetics by catalyzing nicotinamide methylation using the universal methyl donor S-adenosyl-L-methionine. This direct connection bridges the methylation-mediated one-carbon metabolism with nicotinamide adenine dinucleotide levels. Numerous studies have revealed tissue-specific differences in NNMT expression and activity, indicating that its varied physiological and pathological roles depend on its distribution. In this review, we provide an overview of the NNMT involvement in various pathological conditions, including cancer, liver disease, obesity, diabetes, brain disease, pulmonary disease, cardiovascular disease, and kidney disease. By synthesizing this information, our article aims to enhance our understanding of the cellular mechanisms underlying NNMT biology related to diverse diseases and lay the molecular groundwork for developing therapeutic strategies for pharmacological interventions.
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         NAD+
         Drug development
         Methylation
         Pharmacy
         Pharmacology/Toxicology
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                     type:PostalAddress
                  type:Organization
                  name:Chosun University
                  address:
                     name:Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Chosun University
                  address:
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                     type:PostalAddress
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            name:Eun Jin Shin
            affiliation:
                  name:Chosun University
                  address:
                     name:Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Chosun University
                  address:
                     name:Institute of Well-Aging Medicare & Chosun University G-LAMP Project Group, Chosun University, Gwangju, Republic of Korea
                     type:PostalAddress
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                  name:Chosun University
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                     type:PostalAddress
                  type:Organization
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            name:Tae Hyun Kim
            affiliation:
                  name:Sookmyung Women’s University
                  address:
                     name:Drug Information Research Institute, Muscle Physiome Research Center, College of Pharmacy, Sookmyung Women’s University, Seoul, South Korea
                     type:PostalAddress
                  type:Organization
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                  address:
                     name:College of Korean Medicine, Dongshin University, Naju, Republic of Korea
                     type:PostalAddress
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            name:Sung Hwan Ki
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                  address:
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                     type:PostalAddress
                  type:Organization
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            name:Keon Wook Kang
            affiliation:
                  name:Seoul National University
                  address:
                     name:College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kyu Min Kim
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         name:Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, Republic of Korea
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         name:College of Pharmacy, Chosun University, Gwangju, Republic of Korea
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         name:Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, Republic of Korea
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               type:PostalAddress
            type:Organization
      name:Eun Jin Shin
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            name:Chosun University
            address:
               name:Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, Republic of Korea
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            type:Organization
      name:Ji Hye Yang
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            address:
               name:College of Korean Medicine, Dongshin University, Naju, Republic of Korea
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               name:College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
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      name:Kyu Min Kim
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               name:Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, Republic of Korea
               type:PostalAddress
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      name:Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, Republic of Korea
      name:Institute of Well-Aging Medicare & Chosun University G-LAMP Project Group, Chosun University, Gwangju, Republic of Korea
      name:Department of Integrative Biological Sciences & BK21 FOUR Educational Research Group for Age-Associated Disorder Control Technology, Chosun University, Gwangju, Republic of Korea
      name:Drug Information Research Institute, Muscle Physiome Research Center, College of Pharmacy, Sookmyung Women’s University, Seoul, South Korea
      name:College of Korean Medicine, Dongshin University, Naju, Republic of Korea
      name:College of Pharmacy, Chosun University, Gwangju, Republic of Korea
      name:College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
      name:Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, Republic of Korea
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External Links {🔗}(841)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

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