We are analyzing https://link.springer.com/article/10.1007/s12272-009-1607-1.

Title:
Bile acid derivatives from a sponge-associated bacterium Psychrobacter sp. | Archives of Pharmacal Research
Description:
In our search for bioactive metabolites from a marine sponge-associated bacterium Psychrobacter sp., a new bile acid derivative (1), which was assumed to be an artifact, were isolated along with six known (2–7) compounds by bioactivity-guided fractionation. Elucidation of the structure of the new compound was done using a combination of NMR (1H, 13C, HMBC, HSQC, and COSY) and MS spectroscopy. Compound 1 exhibited moderate suppressive effects on both NO and IL-6 production at a concentration of 200 μM (87.3 μg/mL) without significant cytotoxicity against cells. Compounds 2–5 and 7 showed selective inhibitory activity against several human pathogenic bacterial strains at the low concentration of 30 μg/well. In a cytotoxicity evaluation, only compound 7 showed mild cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with ED50 values in the range of 11–14 μg/mL.
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Keywords {🔍}

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Topics {✒️}

12-dihydroxy-3-keto-5fl-cholan-24-oic acids month download article/chapter eun sook yoo 3-keto-5b-cholanic acids hye ja lee marine bacterial taxa bile acid derivatives bile acid derivative authors equally contributed pharmacal research aims korea research institute anti-inflammatory triterpenes full article pdf privacy choices/manage cookies antibacterial substance produced related subjects ursodeoxycholic acid preparation gallstone disease bile acids european economic area bioactivity-guided fractionation antarctic ornithogenic soils pusan national university cheju national university kyung hee university article li conditions privacy policy endogenous antimicrobial activity article archives bioactive cyclic dipeptides accepting optional cookies seoul national university main content log journal finder publish author correspondence bacterium psychrobacter sp 12-oxo derivatives 13c nmr study article log check access instant access article cite marine sponge il-6 production metabolite production chenodeoxycholic acid symbiotic bacteria anti-allergic work rights marine bacterium

Schema {🗺️}

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         headline:Bile acid derivatives from a sponge-associated bacterium Psychrobacter sp.
         description:In our search for bioactive metabolites from a marine sponge-associated bacterium Psychrobacter sp., a new bile acid derivative (1), which was assumed to be an artifact, were isolated along with six known (2–7) compounds by bioactivity-guided fractionation. Elucidation of the structure of the new compound was done using a combination of NMR (1H, 13C, HMBC, HSQC, and COSY) and MS spectroscopy. Compound 1 exhibited moderate suppressive effects on both NO and IL-6 production at a concentration of 200 μM (87.3 μg/mL) without significant cytotoxicity against cells. Compounds 2–5 and 7 showed selective inhibitory activity against several human pathogenic bacterial strains at the low concentration of 30 μg/well. In a cytotoxicity evaluation, only compound 7 showed mild cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with ED50 values in the range of 11–14 μg/mL.
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      headline:Bile acid derivatives from a sponge-associated bacterium Psychrobacter sp.
      description:In our search for bioactive metabolites from a marine sponge-associated bacterium Psychrobacter sp., a new bile acid derivative (1), which was assumed to be an artifact, were isolated along with six known (2–7) compounds by bioactivity-guided fractionation. Elucidation of the structure of the new compound was done using a combination of NMR (1H, 13C, HMBC, HSQC, and COSY) and MS spectroscopy. Compound 1 exhibited moderate suppressive effects on both NO and IL-6 production at a concentration of 200 μM (87.3 μg/mL) without significant cytotoxicity against cells. Compounds 2–5 and 7 showed selective inhibitory activity against several human pathogenic bacterial strains at the low concentration of 30 μg/well. In a cytotoxicity evaluation, only compound 7 showed mild cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with ED50 values in the range of 11–14 μg/mL.
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         Pharmacology/Toxicology
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