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         headline:New Types of Post-Translational Modification of Proteins in Cardiovascular Diseases
         description:Post-translational modifications (PTMs), which are covalent alterations of proteins after their synthesis, are critical for their proper function and the maintenance of cellular physiology. The significance of PTMs in the context of cardiovascular diseases (CVDs) has been increasingly recognized due to their potential to influence protein stability, activity, and localization, thereby affecting the progression of CVDs. The identification and understanding of PTMs in CVDs at the molecular level are vital for the discovery of new biomarkers and new targets for clinical interventions. This article provides a comprehensive overview of the role and mechanisms of new types of PTMs, such as acetylation, crotonylation, succinylation, S-nitrosylation, malonylation, S-palmitonylation, β-hydroxybutyrylation and lactylation, in CVDs, highlighting their importance in advancing diagnostic and therapeutic approaches for CVDs.
         datePublished:2025-03-03T00:00:00Z
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            Crotonylation
            Succinylation
            Lactylation
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      headline:New Types of Post-Translational Modification of Proteins in Cardiovascular Diseases
      description:Post-translational modifications (PTMs), which are covalent alterations of proteins after their synthesis, are critical for their proper function and the maintenance of cellular physiology. The significance of PTMs in the context of cardiovascular diseases (CVDs) has been increasingly recognized due to their potential to influence protein stability, activity, and localization, thereby affecting the progression of CVDs. The identification and understanding of PTMs in CVDs at the molecular level are vital for the discovery of new biomarkers and new targets for clinical interventions. This article provides a comprehensive overview of the role and mechanisms of new types of PTMs, such as acetylation, crotonylation, succinylation, S-nitrosylation, malonylation, S-palmitonylation, β-hydroxybutyrylation and lactylation, in CVDs, highlighting their importance in advancing diagnostic and therapeutic approaches for CVDs.
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      dateModified:2025-03-03T00:00:00Z
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         Crotonylation
         Succinylation
         Lactylation
         Cardiovascular diseases
         Cardiology
         Human Genetics
         Biomedical Engineering and Bioengineering
         Biomedicine
         general
         Medicine/Public Health
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      name:Medical Research Institute, Guangdong Provincial People’S Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China
      name:Medical Research Institute, Guangdong Provincial People’S Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China
      name:Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’S Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China
      name:Department of Experimental Cardiology, University Medical Center Utrecht, Utrecht, Netherlands
      name:CDL Research, University Medical Center Utrecht, Utrecht, Netherlands
      name:Circulatory Health Laboratory, UMC Utrecht, Regenerative Medicine Center Utrecht, University Utrecht, Utrecht, Netherlands
      name:Medical Research Institute, Guangdong Provincial People’S Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China
      name:Medical Research Institute, Guangdong Provincial People’S Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China

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