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Title:
Dysfunction of two lysosome degradation pathways of α-synuclein in Parkinson’s disease: potential therapeutic targets? | Neuroscience Bulletin
Description:
Parkinson’s disease (PD) is pathologically characterized by the presence of α-synuclein (α-syn)-positive intracytoplasmic inclusions named Lewy bodies in the dopaminergic neurons of the substantia nigra. A series of morbid consequences are caused by pathologically high amounts or mutant forms of α-syn, such as defects of membrane trafficking and lipid metabolism. In this review, we consider evidence that both point mutation and overexpression of α-syn result in aberrant degradation in neurons and microglia, and this is associated with the autophagy-lysosome pathway and endosome-lysosome system, leading directly to pathological intracellular aggregation, abnormal externalization and re-internalization cycling (and, in turn, internalization and re-externalization), and exocytosis. Based on these pathological changes, an increasing number of researchers have focused on these new therapeutic targets, aiming at alleviating the pathological accumulation of α-syn and re-establishing normal degradation.
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Keywords {🔍}

article, google, scholar, pubmed, cas, disease, αsynuclein, parkinsons, alphasynuclein, autophagy, lee, cell, neurosci, degradation, privacy, cookies, content, chen, lewy, access, plos, publish, research, search, lysosome, potential, therapeutic, microglia, pathway, body, neuronal, release, biol, model, data, information, log, journal, dysfunction, targets, jiang, shengdi, neurons, αsyn, pathological, aggregation, exocytosis, neurodegeneration, transmission, subjects,

Topics {✒️}

month download article/chapter sheng-di chen disease-related a53t alpha-synuclein a53t alpha-synuclein mutation chaperone-mediated autophagy α-synuclein impairs macroautophagy cell-produced alpha-synuclein alpha-synuclein protein article jiang full article pdf synuclein activates microglia aggregated alpha-synuclein privacy choices/manage cookies decreased alpha-synuclein alpha-synuclein neuropathology autophagy autophagosomes er mutant alpha-synuclein α-synuclein isoform α-synuclein immunoreactivity monomeric α-synuclein extracellular α-synuclein trafficof α-synuclein lewy body diseases establishing normal degradation alpha-synuclein models lysosome degradation pathways endosome-lysosome system α-synuclein overexpression lewy body disease european economic area formic acid pretreatment single-molecule level maguire-zeiss ka calcium-dependent manner atg1/ulk1 complex selective molecular alterations hsp90 regulate recycling ruijin hospital affiliated autophagy-lysosome pathway conditions privacy policy α-syn result pathologically high amounts potential therapeutic applications endocytic pathway abnormality lipid raft interaction disease-linked mutants autophagy fights disease impacts neuronal survival potential therapeutic targets article log

Questions {❓}

Dysfunction of two lysosome degradation pathways of α-synuclein in Parkinson’s disease: potential therapeutic targets?
Dysfunction of two lysosome degradation pathways of α-synuclein in Parkinson’s disease: potential therapeutic targets?

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