We are analyzing https://link.springer.com/article/10.1007/s12253-019-00737-7.

Title:
ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer | Pathology & Oncology Research
Description:
N6-methyladenosine (m6A) demethylase ALKBH5 is best known for modulating transcript modification in plenty of human malignancies, but its role in the progression of colon cancer is not well understood. In the present study, we identified the tumor repressive role of ALKBH5 in colon cancer. ALKBH5 was downregulated in human colon cancer tissues, where its decreased expression significantly correlated with distant metastasis and American Joint Committee on Cancer (AJCC) stage. ALKBH5 was also an independent prognostic indicator of overall survival and disease-free survival in colon cancer patients. Furthermore, functional studies established that overexpression of ALKBH5 inhibited colon cancer cells invasion in vitro and metastasis in vivo. These results indicated that ALKBH5 significantly inhibits tumor progression and serves as a potential therapeutic target for colon cancer.
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Keywords {🔍}

cancer, article, google, scholar, cas, alkbh, colon, wang, cell, yang, liu, colorectal, methylation, chen, journal, metastasis, access, zhang, research, cells, rna, nature, mrna, zhao, china, privacy, cookies, content, prognostic, science, province, road, information, publish, search, inhibits, peipei, zhu, demethylase, human, role, american, open, stem, author, department, hospital, medical, springer, function,

Topics {✒️}

month download article/chapter holds prognostic values il-7/stat5/socs pathways positive feed-forward loop arna-longsage validates fermt1 f-box/wd repeat a-dependent translation control human colorectal cancer related subjects full article pdf rna demethylase alkbh5 breast cancer cells cancer research 17 privacy choices/manage cookies mrna methylation controls potential therapeutic target competing endogenous rna independent prognostic indicator sustaining foxm1 expression disease-free survival tumor repressive role colon cancer patients m6a demethylase alkbh5 modulating transcript modification alkbh5-mediated modulation rna methylation colorectal cancer clin cancer res european economic area functional studies established circadian clock regulation hepatic lipid metabolism ben-haim ms confer oxaliplatin resistance focal adhesion molecules immune checkpoint inhibition cell proliferation program additional information publisher conditions privacy policy jinzhou feng open-label van de wetering fto-dependent demethylation chongqing education committee american joint committee article yang check access instant access colon cancer mrna methylation

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         description:N6-methyladenosine (m6A) demethylase ALKBH5 is best known for modulating transcript modification in plenty of human malignancies, but its role in the progression of colon cancer is not well understood. In the present study, we identified the tumor repressive role of ALKBH5 in colon cancer. ALKBH5 was downregulated in human colon cancer tissues, where its decreased expression significantly correlated with distant metastasis and American Joint Committee on Cancer (AJCC) stage. ALKBH5 was also an independent prognostic indicator of overall survival and disease-free survival in colon cancer patients. Furthermore, functional studies established that overexpression of ALKBH5 inhibited colon cancer cells invasion in vitro and metastasis in vivo. These results indicated that ALKBH5 significantly inhibits tumor progression and serves as a potential therapeutic target for colon cancer.
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