We are analyzing https://link.springer.com/article/10.1007/s12253-014-9784-8.

Title:
Ectopic lymphoid structures in primary cutaneous melanoma | Pathology & Oncology Research
Description:
Ectopic lymphoid structures have been described in several tumor types including metastatic lesions, but not primary tumors, of patients with melanoma. Here we present evidence of B-cell follicles in primary cutaneous melanomas, being present in 39 of 147 cases (27 %). B-cell clusters were associated with T lymphocytes, most of which belonging to CD45RO+ memory T cells. A network of CD21+ follicular dendritic cells was demonstrated in 8 of 22 cases studied (36 %). MECA-79+ HEV-like venules were observed in the neighborhood of the follicles in the majority of cases, however, their presence was not confined to tumors hosting ectopic lymphoid structures. The appearance of B-cell aggregates did not show association with the outcome of the disease, although a trend for their higher prevalence was observed in thicker tumors. Our results show that neogenesis of lymphoid structures does occur in primary melanomas, albeit with lower frequency compared to that reported in metastases.
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Topics {✒️}

t-cell antitumor response month download article/chapter chemokine-secreting dendritic cells mature b-cell malignancies antigen-driven clonal proliferation mature dendritic cells ectopic lymphoid structures small-cell lung cancer dieu-nosjean mc tumor-infiltrating lymphocytes high endothelial venules plasmacytoid dendritic cells primary cutaneous melanoma experimental cancer research b-cell clusters ectopic lymphoid neogenesis tertiary lymphoid structures full article pdf primary cutaneous melanomas human breast carcinomas human melanoma lesions high cd8+/regulatory intratumoral lymphoid structures cells supports functionality privacy choices/manage cookies b-cell aggregates breast carcinoma tissue human lung cancer b-cell follicles b-cell density article ladányi metastatic liver tumors prime tumor-reactive human melanoma metastases van den oord andrea ladányi lymphoid structures european economic area lower frequency compared antibody responses occur long-term survival immunoglobulin genes expressed antigen-driven selection cutaneous melanoma conditions privacy policy accepting optional cookies related subjects article log follicular van baren

Questions {❓}

Messina JL, Fenstermacher DA, Eschrich S, Qu X, Berglund AE, Lloyd MC, Schell MJ, Sondak VK, Weber JS, Mulé JJ (2012) 12-chemokine gene signature identifies lymph node-like structures in melanoma: Potential for patient selection for immunotherapy?
What does it tell us?

Schema {🗺️}

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         description:Ectopic lymphoid structures have been described in several tumor types including metastatic lesions, but not primary tumors, of patients with melanoma. Here we present evidence of B-cell follicles in primary cutaneous melanomas, being present in 39 of 147 cases (27 %). B-cell clusters were associated with T lymphocytes, most of which belonging to CD45RO+ memory T cells. A network of CD21+ follicular dendritic cells was demonstrated in 8 of 22 cases studied (36 %). MECA-79+ HEV-like venules were observed in the neighborhood of the follicles in the majority of cases, however, their presence was not confined to tumors hosting ectopic lymphoid structures. The appearance of B-cell aggregates did not show association with the outcome of the disease, although a trend for their higher prevalence was observed in thicker tumors. Our results show that neogenesis of lymphoid structures does occur in primary melanomas, albeit with lower frequency compared to that reported in metastases.
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      headline:Ectopic lymphoid structures in primary cutaneous melanoma
      description:Ectopic lymphoid structures have been described in several tumor types including metastatic lesions, but not primary tumors, of patients with melanoma. Here we present evidence of B-cell follicles in primary cutaneous melanomas, being present in 39 of 147 cases (27 %). B-cell clusters were associated with T lymphocytes, most of which belonging to CD45RO+ memory T cells. A network of CD21+ follicular dendritic cells was demonstrated in 8 of 22 cases studied (36 %). MECA-79+ HEV-like venules were observed in the neighborhood of the follicles in the majority of cases, however, their presence was not confined to tumors hosting ectopic lymphoid structures. The appearance of B-cell aggregates did not show association with the outcome of the disease, although a trend for their higher prevalence was observed in thicker tumors. Our results show that neogenesis of lymphoid structures does occur in primary melanomas, albeit with lower frequency compared to that reported in metastases.
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