We are analyzing https://link.springer.com/article/10.1007/s12253-013-9691-4.

Title:
Quantification of Blood Dendritic Cells in Colorectal Cancer Patients During the Course of Disease | Pathology & Oncology Research
Description:
Colorectal cancer is a malignancy with poor prognosis that might be associated with defective immune function. The aim of the present study was to investigate circulating dendritic cells in colorectal cancer patients, in order to contribute to elucidate tumor-escape mechanisms and to point out a possible correlation with the clinical condition of the disease. Therefore, we enumerated ex vivo myeloid and plasmacytoid dendritic cells, through multicolor flow cytometry, in 26 colorectal patients and 33 healthy controls. Furthermore we performed several analyses at determined time points in order to define the immunological trend of cancer patients after surgery and other conventional treatments. At the pre-operative time point the absolute number of plasmacytoid dendritic cells in cancer patients was significantly reduced in comparison to controls, this result being mainly referred to stage III-IV patients. The number of myeloid dendritic cells did not show any significant difference compared to healthy controls; interestingly the expression of the tolerogenic antigen CD85k was significantly higher on cancer patients’ myeloid dendritic cells than controls’. At the following samplings, circulating dendritic cell absolute number did not show any difference compared to controls. Conclusively the impairment of the number of circulating dendritic cells may represent one of the tumor escape mechanisms occurring in colorectal cancer. These alterations seem to be correlated to cancer progression. Our work sheds light on one of dendritic cell-based tumor immune escape mechanisms. This knowledge may be useful to the development of more effective immunotherapeutic strategies.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, dendritic, cells, cancer, article, google, scholar, cas, patients, colorectal, cell, immunol, circulating, blood, central, res, myeloid, plasmacytoid, clin, research, role, ilt, pisa, privacy, cookies, function, content, orsini, immune, controls, tumor, access, maturation, tumorinfiltrating, oncol, human, regulatory, subsets, publish, search, legitimo, failli, mechanisms, clinical, number, immunotherapy, rev, van, exp, takahashi,

Topics {✒️}

month download article/chapter stage iii-iv patients monocyte-derived dendritic cells s-100 protein-positive cells multicolor flow cytometry tumor-infiltrating immune cells elucidate tumor-escape mechanisms tumor-infiltrating dendritic cells anti-cancer immune response related subjects systemic t-cell response colorectal adenoma-carcinoma sequence janssen-van rhijn cm plasmacytoid dendritic cells pre-operative time point t-regulatory cells correlate colon cancer full article pdf myeloid dendritic cells circulating dendritic cells suppressor cell cascade human dendritic cells dendritic cell subsets blood dendritic cells dendritic cells involved privacy choices/manage cookies t-cell subsets disease research published dendritic cell defects dendritic cell dysfunction human colorectal cancer colorectal cancer correlate tumor stromal cells janssen-van rhijn della cuna gr antigen-presenting cells dendritic cell function andrea nicolini article orsini tumor-infiltrating macrophages squamous cell carcinoma squamous cell carcinomas de necochea-campion colorectal cancer patients determined time points global cancer statistics individualize cancer treatment conventional treatments tolerogenic antigen cd85k check access

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         description:Colorectal cancer is a malignancy with poor prognosis that might be associated with defective immune function. The aim of the present study was to investigate circulating dendritic cells in colorectal cancer patients, in order to contribute to elucidate tumor-escape mechanisms and to point out a possible correlation with the clinical condition of the disease. Therefore, we enumerated ex vivo myeloid and plasmacytoid dendritic cells, through multicolor flow cytometry, in 26 colorectal patients and 33 healthy controls. Furthermore we performed several analyses at determined time points in order to define the immunological trend of cancer patients after surgery and other conventional treatments. At the pre-operative time point the absolute number of plasmacytoid dendritic cells in cancer patients was significantly reduced in comparison to controls, this result being mainly referred to stage III-IV patients. The number of myeloid dendritic cells did not show any significant difference compared to healthy controls; interestingly the expression of the tolerogenic antigen CD85k was significantly higher on cancer patients’ myeloid dendritic cells than controls’. At the following samplings, circulating dendritic cell absolute number did not show any difference compared to controls. Conclusively the impairment of the number of circulating dendritic cells may represent one of the tumor escape mechanisms occurring in colorectal cancer. These alterations seem to be correlated to cancer progression. Our work sheds light on one of dendritic cell-based tumor immune escape mechanisms. This knowledge may be useful to the development of more effective immunotherapeutic strategies.
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            Immunosuppression
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      headline:Quantification of Blood Dendritic Cells in Colorectal Cancer Patients During the Course of Disease
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         Colorectal cancer
         Immunosuppression
         Flow cytometry
         Cancer Research
         Oncology
         Pathology
         Immunology
         Biomedicine
         general
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