We are analyzing https://link.springer.com/article/10.1007/s12253-012-9500-5.

Title:
Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers | Pathology & Oncology Research
Description:
Cancer cells have accelerated metabolism and high glucose requirements. The up-regulation of specific glucose transporters may represent a key mechanism by which malignant cells may achieve increased glucose uptake to support the high rate of glycolysis. In present study we analyzed the mRNA and protein expression of GLUT1 and GLUT3 glucose transporters by quantitative real-time polymerase chain reaction (Q-PCR) and Western blotting technique in 76 cases of endometrial carcinoma and 70 cases of breast carcinoma. SLC2A1 and SLCA2A3 mRNAs expression was found, respectively in 100% and 97.4% samples of endometrial cancers and only in 50% and 40% samples of breast cancers. In endometrial cancers GLUT1 and GLUT3 protein expression was identified in 67.1% and 30.3% of cases. Analogously, in breast cancers in 48.7% and 21% of samples, respectively. The results showed that both endometrial and breast poorly differentiated tumors (grade 2 and 3) had significantly higher GLUT1 and GLUT3 expression than well-differentiated tumors (grade 1). Statistically significant association was found between SLCA2A3 mRNA expression and estrogen and progesterone receptors status in breast cancers. GLUT1 has been reported to be involved in the uptake of glucose by endometrial and breast carcinoma cells earlier and the present study determined that GLUT3 expression is also involved. GLUT1 and GLUT3 seem to be important markers in endometrial and breast tumors differentiation.
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

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         headline:Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers
         description:Cancer cells have accelerated metabolism and high glucose requirements. The up-regulation of specific glucose transporters may represent a key mechanism by which malignant cells may achieve increased glucose uptake to support the high rate of glycolysis. In present study we analyzed the mRNA and protein expression of GLUT1 and GLUT3 glucose transporters by quantitative real-time polymerase chain reaction (Q-PCR) and Western blotting technique in 76 cases of endometrial carcinoma and 70 cases of breast carcinoma. SLC2A1 and SLCA2A3 mRNAs expression was found, respectively in 100% and 97.4% samples of endometrial cancers and only in 50% and 40% samples of breast cancers. In endometrial cancers GLUT1 and GLUT3 protein expression was identified in 67.1% and 30.3% of cases. Analogously, in breast cancers in 48.7% and 21% of samples, respectively. The results showed that both endometrial and breast poorly differentiated tumors (grade 2 and 3) had significantly higher GLUT1 and GLUT3 expression than well-differentiated tumors (grade 1). Statistically significant association was found between SLCA2A3 mRNA expression and estrogen and progesterone receptors status in breast cancers. GLUT1 has been reported to be involved in the uptake of glucose by endometrial and breast carcinoma cells earlier and the present study determined that GLUT3 expression is also involved. GLUT1 and GLUT3 seem to be important markers in endometrial and breast tumors differentiation.
         datePublished:2012-01-21T00:00:00Z
         dateModified:2012-01-21T00:00:00Z
         pageStart:721
         pageEnd:728
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         sameAs:https://doi.org/10.1007/s12253-012-9500-5
         keywords:
            Glucose transporters
            mRNA expression
            Protein expression
            Breast cancer
            Endometrial cancer
            Cancer Research
            Oncology
            Pathology
            Immunology
            Biomedicine
            general
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      headline:Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers
      description:Cancer cells have accelerated metabolism and high glucose requirements. The up-regulation of specific glucose transporters may represent a key mechanism by which malignant cells may achieve increased glucose uptake to support the high rate of glycolysis. In present study we analyzed the mRNA and protein expression of GLUT1 and GLUT3 glucose transporters by quantitative real-time polymerase chain reaction (Q-PCR) and Western blotting technique in 76 cases of endometrial carcinoma and 70 cases of breast carcinoma. SLC2A1 and SLCA2A3 mRNAs expression was found, respectively in 100% and 97.4% samples of endometrial cancers and only in 50% and 40% samples of breast cancers. In endometrial cancers GLUT1 and GLUT3 protein expression was identified in 67.1% and 30.3% of cases. Analogously, in breast cancers in 48.7% and 21% of samples, respectively. The results showed that both endometrial and breast poorly differentiated tumors (grade 2 and 3) had significantly higher GLUT1 and GLUT3 expression than well-differentiated tumors (grade 1). Statistically significant association was found between SLCA2A3 mRNA expression and estrogen and progesterone receptors status in breast cancers. GLUT1 has been reported to be involved in the uptake of glucose by endometrial and breast carcinoma cells earlier and the present study determined that GLUT3 expression is also involved. GLUT1 and GLUT3 seem to be important markers in endometrial and breast tumors differentiation.
      datePublished:2012-01-21T00:00:00Z
      dateModified:2012-01-21T00:00:00Z
      pageStart:721
      pageEnd:728
      license:https://creativecommons.org/licenses/by-nc/2.0
      sameAs:https://doi.org/10.1007/s12253-012-9500-5
      keywords:
         Glucose transporters
         mRNA expression
         Protein expression
         Breast cancer
         Endometrial cancer
         Cancer Research
         Oncology
         Pathology
         Immunology
         Biomedicine
         general
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12253-012-9500-5/MediaObjects/12253_2012_9500_Fig1_HTML.gif
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                  name:University of Lodz
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            type:Person
            name:Katarzyna Wojcik-Krowiranda
            affiliation:
                  name:Medical University of Lodz
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                     name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
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                  type:Organization
            type:Person
            name:Ewa Forma
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                  name:University of Lodz
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                  name:University of Lodz
                  address:
                     name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
                     type:PostalAddress
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            type:Person
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            affiliation:
                  name:Polish Mother’s Memorial Hospital Research Institute
                  address:
                     name:Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Łodz, Poland
                     type:PostalAddress
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            type:Person
            name:Andrzej Bienkiewicz
            affiliation:
                  name:Medical University of Lodz
                  address:
                     name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
                     type:PostalAddress
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            name:Magdalena Brys
            affiliation:
                  name:University of Lodz
                  address:
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         type:PostalAddress
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      address:
         name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
         type:PostalAddress
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      address:
         name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
         type:PostalAddress
      name:Polish Mother’s Memorial Hospital Research Institute
      address:
         name:Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Łodz, Poland
         type:PostalAddress
      name:Medical University of Lodz
      address:
         name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
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      address:
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            address:
               name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Katarzyna Wojcik-Krowiranda
      affiliation:
            name:Medical University of Lodz
            address:
               name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Ewa Forma
      affiliation:
            name:University of Lodz
            address:
               name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Paweł Jozwiak
      affiliation:
            name:University of Lodz
            address:
               name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Hanna Romanowicz
      affiliation:
            name:Polish Mother’s Memorial Hospital Research Institute
            address:
               name:Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Łodz, Poland
               type:PostalAddress
            type:Organization
      name:Andrzej Bienkiewicz
      affiliation:
            name:Medical University of Lodz
            address:
               name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
               type:PostalAddress
            type:Organization
      name:Magdalena Brys
      affiliation:
            name:University of Lodz
            address:
               name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
               type:PostalAddress
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      name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
      name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
      name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
      name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland
      name:Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Łodz, Poland
      name:Department of Gynecological Oncology, Medical University of Lodz, Lodz, Poland
      name:Department of Cytobiochemistry, University of Lodz, Lodz, Poland

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