We are analyzing https://link.springer.com/article/10.1007/s12192-023-01320-5.

Title:
The association and clinical relevance of phase-separating protein CAPRIN1 with noncoding RNA | Cell Stress and Chaperones
Description:
CAPRIN1, cell cycle–associated protein 1, is an RNA-binding protein in stress granules, P bodies, and messenger RNA transport granules and has a high level of expression in cancer. It promotes the proliferation and invasion of cancer cells and enhances their glycolysis and chemoresistance. In addition, it mediates the formation of intracellular SGs in various ways when exposed to endogenous and exogenous stress. As an RNA-binding protein, it not only directly binds to several mRNAs associated with the cell cycle but also is the target of miRNA, lncRNA, and circRNA. Recently, CAPRIN1 is identified as a phase-separating protein that mediates the liquid–liquid phase separation within tumor cells. Moreover, the formation of CAPRIN1-mediated phase separation is regulated by circRNA and lncRNA. In addition, CAPRIN1 is associated with ubiquitination, which affects the relevant characteristics of cancer cells. This review discusses the different regulatory mechanisms of CAPRIN1 in various tumors and its association with noncoding RNA, suggesting its potential as an oncogenic signal and possibly as a diagnostic indicator in the future. This may provide the multifunctional characteristic insight of CAPRIN1 protein and potential therapeutic target in malignancy with high levels of CAPRIN1.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, caprin, zhang, central, cell, wang, chen, stress, protein, promotes, proliferation, carcinoma, rna, cells, noncoding, peng, res, liu, invasion, proteins, huang, sun, zhao, sci, zhu, hunan, privacy, cookies, content, information, shuping, phase, separation, access, survival, hepatocellular, biol, springer, analysis, publish, research, search, clinical, january, mojian,

Topics {✒️}

month download article/chapter liquid–liquid phase separation liquid-liquid phase separation caprin1-mediated phase separation suppressing c-myc translation wnt/beta-catenin pathway mvp-mediated exosomal sorting regulated protein-rna interactome phase-separating protein caprin1 rna-binding protein article cell stress central south university full article pdf inhibits hepatocellular carcinoma calmodulin-binding domain phase-separating protein hunan key laboratory privacy choices/manage cookies epigenetically upregulating caprin1 noncoding rna shuping peng human pancreatic cancer related subjects suppress glutaminase-1 translation mir-1 downregulation correlates cellular signaling hub chaperones article akt/erk1 pathway basic medical science colorectal cancer cells holds exclusive rights cyr61-interacting protein zinc finger protein cytoplasmic stress granules european economic area multifunctional characteristic insight regulates treatment response wild type grb7 weakening transient interactions distinct structural features accepted manuscript version gastric cancer cells article zhang proteins implicated cytoplasmic activation/proliferation conditions privacy policy article log microrna-181a functions lnc-ma301 interacts key laboratory

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         description:CAPRIN1, cell cycle–associated protein 1, is an RNA-binding protein in stress granules, P bodies, and messenger RNA transport granules and has a high level of expression in cancer. It promotes the proliferation and invasion of cancer cells and enhances their glycolysis and chemoresistance. In addition, it mediates the formation of intracellular SGs in various ways when exposed to endogenous and exogenous stress. As an RNA-binding protein, it not only directly binds to several mRNAs associated with the cell cycle but also is the target of miRNA, lncRNA, and circRNA. Recently, CAPRIN1 is identified as a phase-separating protein that mediates the liquid–liquid phase separation within tumor cells. Moreover, the formation of CAPRIN1-mediated phase separation is regulated by circRNA and lncRNA. In addition, CAPRIN1 is associated with ubiquitination, which affects the relevant characteristics of cancer cells. This review discusses the different regulatory mechanisms of CAPRIN1 in various tumors and its association with noncoding RNA, suggesting its potential as an oncogenic signal and possibly as a diagnostic indicator in the future. This may provide the multifunctional characteristic insight of CAPRIN1 protein and potential therapeutic target in malignancy with high levels of CAPRIN1.
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         Neurosciences
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