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Keywords {🔍}

pubmed, article, cancer, google, scholar, hsp, spag, cas, antigen, patients, cell, lung, central, proteins, carcinoma, levels, antibody, serum, hcc, ren, hepatocellular, tumor, potential, heat, shock, stress, chaperones, expression, huang, protein, hunan, privacy, cookies, content, research, damp, cancertestis, zou, immune, higher, subjects, spermassociated, sperm, immunol, res, cells, information, publish, search, december,

Topics {✒️}

month download article/chapter her2-induced mammary tumorigenesis heat shock protein article cell stress cancer-testis antigen spag9 full article pdf epithelial ovarian cancer privacy choices/manage cookies damp proteins hsp70 explore tumor immunity cta combined research traditional chinese medicine cancer testis antigen hunan province foundation article ren lung cancer patients hepatocellular carcinoma chaperones biqiong ren european economic area dimensional gel electrophoresis double-edged sword human spag9 gene molecular pattern molecules damp proteins conditions privacy policy spag9 reduces growth cambridge university press tlr signaling pathways hepatitis/cirrhosis patients article log accepting optional cookies immune system participates related subjects cell stress recombinant human sperm tumor-specific biomarker clonal selection theory damps biomarkers human hsp70 family chaperones article serum spag9 antibody ethics declarations conflict lung cancer breast cancer lung cancer 81 journal finder publish article cite author information authors biqiong ren

Questions {❓}

• Radons J (2016) The human HSP70 family of chaperones: where do we stand?

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         headline:The expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in peripheral blood of patients with HCC and lung cancer
         description:There are different views of how the immune system participates in the reaction to cancer. Here, we evaluated expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in patients with hepatocellular carcinoma (HCC) and lung cancer to explore tumor immunity. Our analysis showed that levels of HSP70 and SPAG9 antibody were significantly higher in the serum of lung cancer and HCC patients than in the serum of healthy subjects (P < 0.001), but there were no differences in levels of HSP70 antibody in patients and controls. Levels of serum SPAG9 antibody in newly diagnosed lung cancer patients were significantly higher than in treated lung cancer patients (P < 0.05), but there were no differences in levels of HSP70 or HSP70 antibody. Levels of serum HSP70 and SPAG9 antibody, but not HSP70 antibody, were also higher in hepatitis/cirrhosis patients than in healthy subjects (P = 0.005, P < 0.001). Levels of serum SPAG9 antibody were significantly higher in HCC patients than in hepatitis/cirrhosis patients, but there were no differences in HSP70 or HSP70 antibody levels. Finally, levels of serum HSP70 and SPAG9 antibody were significantly higher in HCC patients than in lung cancer patients (P < 0.05, P < 0.001). These results indicate that cancer-testis antigen SPAG9 induces a strong humoral immune response in cancer patients but HSP70 does not. These results show that SPAG9 has potential as a tumor-specific biomarker.
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      headline:The expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in peripheral blood of patients with HCC and lung cancer
      description:There are different views of how the immune system participates in the reaction to cancer. Here, we evaluated expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in patients with hepatocellular carcinoma (HCC) and lung cancer to explore tumor immunity. Our analysis showed that levels of HSP70 and SPAG9 antibody were significantly higher in the serum of lung cancer and HCC patients than in the serum of healthy subjects (P < 0.001), but there were no differences in levels of HSP70 antibody in patients and controls. Levels of serum SPAG9 antibody in newly diagnosed lung cancer patients were significantly higher than in treated lung cancer patients (P < 0.05), but there were no differences in levels of HSP70 or HSP70 antibody. Levels of serum HSP70 and SPAG9 antibody, but not HSP70 antibody, were also higher in hepatitis/cirrhosis patients than in healthy subjects (P = 0.005, P < 0.001). Levels of serum SPAG9 antibody were significantly higher in HCC patients than in hepatitis/cirrhosis patients, but there were no differences in HSP70 or HSP70 antibody levels. Finally, levels of serum HSP70 and SPAG9 antibody were significantly higher in HCC patients than in lung cancer patients (P < 0.05, P < 0.001). These results indicate that cancer-testis antigen SPAG9 induces a strong humoral immune response in cancer patients but HSP70 does not. These results show that SPAG9 has potential as a tumor-specific biomarker.
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         Sperm-associated antigen 9
         Auto-antibody
         Hepatocellular carcinoma
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• Earnings of https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations
• What's the financial intake of https://www.springernature.com/?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Clipboard.js
• Foundation
• Prism.js