We are analyzing https://link.springer.com/article/10.1007/s12185-014-1641-8.

Title:
Aging of the hematopoietic stem cells niche | International Journal of Hematology
Description:
Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.
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Keywords {🔍}

pubmed, cells, cell, google, scholar, stem, niche, cas, hematopoietic, aged, aging, hscs, mice, central, hsc, bone, marrow, agerelated, microenvironment, young, age, nature, function, potential, niches, progenitor, signaling, mouse, studies, mscs, cellular, systemic, haematopoietic, differentiation, myeloid, endothelial, adhesion, mobilization, system, transplantation, specific, cre, blood, dev, change, selfrenewal, factors, regulates, mesenchymal, study,

Topics {✒️}

ve-cadherin-cre-recombinase transgenic mouse ve-cadherin-creert2 transgenic mouse lipoatrophic a-zip/f1 mice haematopoietic stem-cell niche vascular-derived tgf-β increases spleen colony-forming cell spleen colony-forming cells haematopoietic stem-cell maintenance pigment epithelium-derived factor ayako nakamura-ishizu cancer-stem-cell research adenosine triphosphate-binding cassette activating β-catenin mutation atp-binding cassette transporters small rho gtpase haematopoietic stem cells aml-eto fusion protein osterix-positive stromal cells tie2-cre transgenic mice article nakamura-ishizu ubc-creer t2 mice dmp1-targeted cre expression double-transgenic mouse model cell-specific depletion models mech ageing dev age-related hematopoietic diseases cxcl12-cxcr4 chemokine signaling higher myeloid/platelet output hematopoietic stem cells multi-lineage differentiation potential cell stem cell satellite cell activation stem cell factor stem cell niches time-lapse intravital imaging vivo cell-specific deletion age-related thymic involution adult mouse brain murine hematopoietic stem leukaemia stem cells endothelial cell-lineage analysis mesenchymal stem cells extracellular matrix proteins e-cadherin-mediated adhesion vivo fate-tracing studies early mesenchymal progenitors stem cell niche hematopoietic system occurs haemopoietic stem cell chronic lymphocytic leukemia

Schema {🗺️}

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         description: Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.
         datePublished:2014-08-06T00:00:00Z
         dateModified:2014-08-06T00:00:00Z
         pageStart:317
         pageEnd:325
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            Hematopoietic stem cells
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            Bone marrow
            Hematology
            Oncology
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      headline:Aging of the hematopoietic stem cells niche
      description: Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.
      datePublished:2014-08-06T00:00:00Z
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         Hematology
         Oncology
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      author:
            name:Ayako Nakamura-Ishizu
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                     name:Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University, Tokyo, Japan
                     type:PostalAddress
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            type:Person
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Organization:
      name:Springer Japan
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      name:Keio University
      address:
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Person:
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      affiliation:
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            address:
               name:Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University, Tokyo, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Toshio Suda
      affiliation:
            name:Keio University
            address:
               name:Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University, Tokyo, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University, Tokyo, Japan
      name:Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University, Tokyo, Japan

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