We are analyzing https://link.springer.com/article/10.1007/s12094-024-03675-2.

Title:
SLAM family-mediated crosstalk between tumor and immune cells in the tumor microenvironment: a promising biomarker and a potential therapeutic target for immune checkpoint therapies | Clinical and Translational Oncology
Description:
Immune cells infiltrating the tumor microenvironment are physiologically important in controlling cancers. However, emerging studies have shown that cancer cells can evade immune surveillance and establish a balance in which these immune cells support tumor progression and therapeutic resistance. The signaling lymphocytic activation molecule family members have been recognized as mediators of tumor microenvironment interactions, and a promising therapeutic target for cancer immunotherapy. This review is focused on the role of SLAM family in tumor and immune cell interactions and discusses how such crosstalk affects tumor behavior. This will shed insight into the next step toward improving cancer immunotherapy.
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, cells, cancer, immune, tumor, cell, slamf, immunol, family, wang, microenvironment, zhang, kwantwi, immunotherapy, slam, checkpoint, signaling, receptors, resistance, clin, res, oncol, chen, therapeutic, target, lymphocytic, molecule, access, neutrophils, breast, front, crosstalk, cancers, activation, expression, sci, carcinoma, nature, leukemia, author, privacy, cookies, content, role, blockade,

Topics {✒️}

g-csf-rln2-mmp-9 axis month download article/chapter slam family-mediated crosstalk myeloid-derived suppressor cells louis boafo kwantwi tumor-infiltrating nk cells potentiates pd-l1 blockade anti-pd-1/pd-l1 haematopoietic tumour cells peripheral t-cell lymphomas immune checkpoints enhances ifn-γ secretion mir-204–5p/myh9 axis immune checkpoint molecule checkpoint inhibitors immune-cell receptors slam-family receptors slam family receptors independent prognosis factor cell receptor signaling kwantwi lb human nk cells chronic lymphocytic leukemia anti-myeloma immunotherapies targeting slamf receptors innate immune cells immune checkpoint blockade tumor immune microenvironment nk cell recognition translational oncology aims article kwantwi immune cell interactions anti-pd-l1 full article pdf immune checkpoint therapies natural killer cells1 hepatocellular carcinoma cells slamf7 signaling reprograms exosome-mediated crosstalk cancer immunotherapy resistance boafo kwantwi slam-sap families blocking immune checkpoint tumor microenvironment interactions tumor microenvironment imaging privacy choices/manage cookies homophilic adhesion molecule sap-related adaptors evade immune surveillance adaptive immune responses

Questions {❓}

How do SAP family deficiencies compromise immunity?
Signaling lymphocytic activation molecules Slam and cancers: friends or foes?

Schema {🗺️}

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         description:Immune cells infiltrating the tumor microenvironment are physiologically important in controlling cancers. However, emerging studies have shown that cancer cells can evade immune surveillance and establish a balance in which these immune cells support tumor progression and therapeutic resistance. The signaling lymphocytic activation molecule family members have been recognized as mediators of tumor microenvironment interactions, and a promising therapeutic target for cancer immunotherapy. This review is focused on the role of SLAM family in tumor and immune cell interactions and discusses how such crosstalk affects tumor behavior. This will shed insight into the next step toward improving cancer immunotherapy.
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