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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s12072-023-10490-4.

Title:
Metabolic interventions improve HBV envelope-specific T-cell responses in patients with chronic hepatitis B | Hepatology International
Description:
Background Restoration of HBV-specific T cell immunity is a promising approach for the functional cure of chronic Hepatitis B (CHB), necessitating the development of valid assays to boost and monitor HBV-specific T cell responses in patients with CHB. Methods We analyzed hepatitis B virus (HBV) core- and envelope (env)-specific T cell responses using in vitro expanded peripheral blood mononuclear cells (PBMCs) from patients with CHB exhibiting different immunological phases, including immune tolerance (IT), immune activation (IA), inactive carrier (IC), and HBeAg-negative hepatitis (ENEG). Additionally, we evaluated the effects of metabolic interventions, including mitochondria-targeted antioxidants (MTA), polyphenolic compounds, and ACAT inhibitors (iACAT), on HBV-specific T-cell functionality. Results We found that HBV core- and env-specific T cell responses were finely coordinated and more profound in IC and ENEG than in the IT and IA stages. HBV env-specific T cells were more dysfunctional but prone to respond to metabolic interventions using MTA, iACAT, and polyphenolic compounds than HBV core-specific T-cells. The responsiveness of HBV env-specific T cells to metabolic interventions can be predicted by the eosinophil (EO) count and the coefficient of variation of red blood cell distribution width (RDW-CV). Conclusion These findings may provide valuable information for metabolically invigorating HBV-specific T-cells to treat CHB. Graphical abstract
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Health & Fitness
  • Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

hbv, tcells, hbvspecific, pubmed, tcell, responses, patients, article, envspecific, hepatitis, google, scholar, cells, metabolic, chronic, cas, cell, infection, levels, fig, interventions, chb, core, hbsag, virus, corespecific, elispot, ifnγ, clinical, functional, immune, response, aim, central, mta, stages, viral, function, study, hbeag, positive, treatments, hepatol, cure, eneg, antiviral, treatment, correlation, showed, data,

Topics {✒️}

hbv-specific cd8 + t-cell responses restoring hbv-specific cd8 + t-cells including mitochondria-targeted antioxidants hbv-specific t-cell responses hbv-specific t-cell functionality env-specific t-cell responses env-specific t-cell response core-specific t-cell responses cd8 + t-cell-mediated effects hbv-specific t-cell function env-specific t-cell reactivity hbv-specific cd8 + t-cells t-cell-directed therapy development specific ifn-γ-secreting cells env-specific cd8 + t-cells env-specific t-cells tended hbv env-specific t-cells core-specific cd8 + t-cells core-specific cd8 + t-cells [22 measure hbv-specific t-cells hbv core-specific t-cells functional hbv-specific t-cells env-specific ifn-γ + sfu specific t-cell responses core-specific ifn-γ + sfu delayed t-cell response t-cell responses targeting exhausted hbv-specific cd8 targeting t-cell metabolism t-cell-based therapies polymerase-specific t-cells article download pdf specific t-cell dysfunction hbv-specific t-cells hbv-specific t-cells [32 cd8 + t-cells recognizing antigen-specific t-cells fu-sheng wang env-specific t-cells env-specific t-cells [20 vivo t-cell responses core-specific t-cells provide long-term benefits ifn-γ + sfu produced functional hbv-specific cd8 sterile phosphate-buffered saline anti-ifn-γ af647 long-term nas resulted stop long-term treatment ifn-γ + sfu derived

Questions {❓}

  • How to achieve functional cure of HBV: stopping NUCs, adding interferon or new drug development?
  • Restoration of a functional antiviral immune response to chronic HBV infection by reducing viral antigen load: if not sufficient, is it necessary?

Schema {🗺️}

WebPage:
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         headline:Metabolic interventions improve HBV envelope-specific T-cell responses in patients with chronic hepatitis B
         description:Restoration of HBV-specific T cell immunity is a promising approach for the functional cure of chronic Hepatitis B (CHB), necessitating the development of valid assays to boost and monitor HBV-specific T cell responses in patients with CHB. We analyzed hepatitis B virus (HBV) core- and envelope (env)-specific T cell responses using in vitro expanded peripheral blood mononuclear cells (PBMCs) from patients with CHB exhibiting different immunological phases, including immune tolerance (IT), immune activation (IA), inactive carrier (IC), and HBeAg-negative hepatitis (ENEG). Additionally, we evaluated the effects of metabolic interventions, including mitochondria-targeted antioxidants (MTA), polyphenolic compounds, and ACAT inhibitors (iACAT), on HBV-specific T-cell functionality. We found that HBV core- and env-specific T cell responses were finely coordinated and more profound in IC and ENEG than in the IT and IA stages. HBV env-specific T cells were more dysfunctional but prone to respond to metabolic interventions using MTA, iACAT, and polyphenolic compounds than HBV core-specific T-cells. The responsiveness of HBV env-specific T cells to metabolic interventions can be predicted by the eosinophil (EO) count and the coefficient of variation of red blood cell distribution width (RDW-CV). These findings may provide valuable information for metabolically invigorating HBV-specific T-cells to treat CHB.
         datePublished:2023-03-28T00:00:00Z
         dateModified:2023-03-28T00:00:00Z
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      headline:Metabolic interventions improve HBV envelope-specific T-cell responses in patients with chronic hepatitis B
      description:Restoration of HBV-specific T cell immunity is a promising approach for the functional cure of chronic Hepatitis B (CHB), necessitating the development of valid assays to boost and monitor HBV-specific T cell responses in patients with CHB. We analyzed hepatitis B virus (HBV) core- and envelope (env)-specific T cell responses using in vitro expanded peripheral blood mononuclear cells (PBMCs) from patients with CHB exhibiting different immunological phases, including immune tolerance (IT), immune activation (IA), inactive carrier (IC), and HBeAg-negative hepatitis (ENEG). Additionally, we evaluated the effects of metabolic interventions, including mitochondria-targeted antioxidants (MTA), polyphenolic compounds, and ACAT inhibitors (iACAT), on HBV-specific T-cell functionality. We found that HBV core- and env-specific T cell responses were finely coordinated and more profound in IC and ENEG than in the IT and IA stages. HBV env-specific T cells were more dysfunctional but prone to respond to metabolic interventions using MTA, iACAT, and polyphenolic compounds than HBV core-specific T-cells. The responsiveness of HBV env-specific T cells to metabolic interventions can be predicted by the eosinophil (EO) count and the coefficient of variation of red blood cell distribution width (RDW-CV). These findings may provide valuable information for metabolically invigorating HBV-specific T-cells to treat CHB.
      datePublished:2023-03-28T00:00:00Z
      dateModified:2023-03-28T00:00:00Z
      pageStart:1125
      pageEnd:1138
      license:http://creativecommons.org/licenses/by/4.0/
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         HBV
         T-cell responses
         Core
         Envelope
         Metabolic interventions
         Mitochondria-targeted antioxidants
         Polyphenolic compounds
         ACAT inhibitors
         Eosinophil
         RDW-CV
         Hepatology
         Colorectal Surgery
         Surgery
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            type:ImageObject
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      author:
            name:Yu-Long Fu
            affiliation:
                  name:University of Chinese Academy of Sciences
                  address:
                     name:Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:The Fifth Medical Center of Chinese PLA General Hospital
                  address:
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            type:Person
            name:Shuang-Nan Zhou
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                  address:
                     name:Senior Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
                     type:PostalAddress
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            type:Person
            name:Wei Hu
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                  name:The Fifth Medical Center of Chinese PLA General Hospital
                  address:
                     name:Senior Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
                     type:PostalAddress
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            type:Person
            name:Jing Li
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                  address:
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                  name:The Fifth Medical Center of Chinese PLA General Hospital
                  address:
                     name:Senior Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
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                  address:
                     name:Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China
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                     type:PostalAddress
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                     name:Senior Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
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